Patents by Inventor Carlos J. Bosques

Carlos J. Bosques has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLYCOPROTEINS WITH ANTI-INFLAMMATORY PROPERTIES
    Publication number: 20180305440
    Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
    Type: Application
    Filed: April 19, 2018
    Publication date: October 25, 2018
    Inventors: Hetal Sarvaiya, Nathaniel J. Washburn, Enrique Arevalo, Carlos J. Bosques
  • Galactose-alpha-1, 3-galactose-containing n-glycans in glycoprotein products derived from CHO cells
    Patent number: 10023894
    Abstract: Methods of producing recombinant therapeutic fusion proteins described herein can include culturing Chinese hamster ovary (CHO) cells under conditions suitable for expression of a recombinant therapeutic fusion protein including one or more glycans, where the CHO cells have not been genetically engineered to produce terminal alpha-galactosyl residues on glycans; treating the one or more glycans of the recombinant glycoprotein with one or more exoglycosidases; measuring glycans containing terminal galactose-alpha-1-3-galactose residues on the fusion protein by nuclear magnetic resonance (NMR); and producing a recombinant therapeutic fusion protein in the CHO cells if a target level of terminal galactose-alpha-1-3-galactose residues is measured.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: July 17, 2018
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Carlos J. Bosques, Jennifer Murphy, Hetal Sarvaiya, Nathaniel Washburn, Cuihua Liu, Xiao-Jin Xu
  • Multi-dimensional chromatographic methods for separating N-glycans
    Patent number: 9933432
    Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: April 3, 2018
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
  • High mannose glycans
    Patent number: 9921210
    Abstract: Methods and compositions related to high mannose glycans are described.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: March 20, 2018
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Brian Edward Collins, Jay Duffner, Carlos J. Bosques, Dorota A. Bulik, James Myette, James Meador
  • N-acetylhexosamine-containing N-glycans in glycoprotein products
    Patent number: 9890410
    Abstract: The present invention provides methods of evaluating a glycoprotein preparation for the absence, presence or amount of an N-acetylhexosamine glycan, e.g., an N-acetylglucosamine glycan.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: February 13, 2018
    Assignee: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Nathaniel Washburn, Enrique Arevalo, Kevin Millea, Carlos J. Bosques, Jay Duffner, Brian Edward Collins
  • MODIFIED GLYCOPROTEINS
    Publication number: 20170349662
    Abstract: Modified glycoproteins, and methods of making and using such modified glycoproteins, are described.
    Type: Application
    Filed: April 25, 2017
    Publication date: December 7, 2017
    Inventors: Nathaniel Washburn, James Meador, III, Carlos J. Bosques, Dorota A. Bulik, Naveen Bhatnagar, Julia Brown, Lynn Markowitz, Sathya Prabbhakar
  • MODIFIED GLYCOPROTEINS
    Publication number: 20170247426
    Abstract: Sulfated glycoproteins, and methods of making and using such sulfated glycoproteins, are described.
    Type: Application
    Filed: April 10, 2017
    Publication date: August 31, 2017
    Inventors: Dorota A. Bulik, Carlos J. Bosques, Brian Edward Collins, Maurice Gaston Hains, Nathaniel J. Washburn, James Meador, Sean Smith, Naveen Bhatnagar
  • MULTI-DIMENSIONAL CHROMATOGRAPHIC METHODS FOR SEPARATING N-GLYCANS
    Publication number: 20170212129
    Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.
    Type: Application
    Filed: April 6, 2017
    Publication date: July 27, 2017
    Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
  • Methods related to denosumab
    Patent number: 9695244
    Abstract: The present invention relates to the characterization and production of denosumab.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: July 4, 2017
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: John Robblee, Brian Edward Collins, Ganesh Kaundinya, Carlos J. Bosques
  • Modified glycoproteins
    Patent number: 9663581
    Abstract: Modified glycoproteins, and methods of making and using such modified glycoproteins, are described.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: May 30, 2017
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Nathaniel Washburn, James Meador, III, Carlos J. Bosques, Dorota A. Bulik, Naveen Bhatnagar, Julia Brown, Lynn Markowitz, Sathya Prabbhakar
  • Modified glycoproteins
    Patent number: 9650433
    Abstract: Sulfated glycoproteins, and methods of making and using such sulfated glycoproteins, are described.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: May 16, 2017
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Dorota A. Bulik, Carlos J. Bosques, Brian Edward Collins, Maurice Gaston Hains, Nathaniel J. Washburn, James Meador, Sean Smith, Naveen Bhatnagar
  • COMPOSITIONS AND METHODS RELATED TO ENGINEERED Fc CONSTRUCTS
    Publication number: 20170066826
    Abstract: The present invention relates to compositions and methods of engineered IgG Fc constructs, wherein said Fc constructs include one or more Fc domains.
    Type: Application
    Filed: April 28, 2016
    Publication date: March 9, 2017
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Carlos J. BOSQUES, James S. HUSTON, Jonathan C. LANSING, Leona E. LING, James MEADOR, III, Daniel ORTIZ, Laura RUTITZKY, Birgit C. SCHULTES
  • METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF KAWASAKI DISEASE
    Publication number: 20170052200
    Abstract: The present invention relates to the determination of levels or expression of particular biomarkers in biological samples which can be utilized to diagnose, prognose, and treat Kawasaki disease in subjects, and further to select subjects who would benefit from a Kawasaki disease therapy other than, or in addition to, IVIG treatment. Accordingly, the present invention encompasses methods and compositions that utilize these biomarkers for the diagnosis, prognosis, and treatment of Kawasaki disease.
    Type: Application
    Filed: May 1, 2015
    Publication date: February 23, 2017
    Inventors: Dorota A. BULIK, Jay DUFFNER, Leona E. LING, Hetal SARVAIYA, Carlos J. BOSQUES
  • MULTI-DIMENSIONAL CHROMATOGRAPHIC METHODS FOR SEPARATING N-GLYCANS
    Publication number: 20160356783
    Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 8, 2016
    Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
  • Multi-dimensional chromatographic methods for separating N-glycans
    Patent number: 9448147
    Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: September 20, 2016
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
  • COMPOSITIONS AND METHODS RELATED TO ENGINEERED Fc CONSTRUCTS
    Publication number: 20160229913
    Abstract: The present invention relates to compositions and methods of engineered IgG Fc constructs, wherein said Fc constructs include one or more Fc domains.
    Type: Application
    Filed: April 28, 2016
    Publication date: August 11, 2016
    Inventors: Carlos J. BOSQUES, James S. HUSTON, Jonathan C. LANSING, Leona E. LING, James MEADOR, III, Daniel ORTIZ, Laura RUTITZKY, Birgit C. SCHULTES
  • DEFINED GLYCOPROTEIN PRODUCTS AND RELATED METHODS
    Publication number: 20160097074
    Abstract: The invention provides methods, databases and systems for making glycoprotein products having defined properties.
    Type: Application
    Filed: October 14, 2015
    Publication date: April 7, 2016
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Brian Edward Collins, Carlos J. Bosques, Lakshmanan Thiruneelakantapillai, Dorota A. Bulik, Ian C. Parsons, Zachary Shriver, Rajeev Chillakuru, Ganesh Kaundinya
  • METHODS FOR THE TREATMENT OF NEURODEGENERATION
    Publication number: 20160090409
    Abstract: The invention encompasses the discovery that Fc-containing polypeptides that include branched glycans and that are sialylated on the branched glycan (e.g., on an ? 1,3 and/or ? 1,6 arm in the Fc region's N-linked glycosylation site), with, e.g., a NeuAc-? 2,6-Gal or NeuAc-? 2,3-Gal terminal linkage, are useful in treating neurodegeneration, e.g., in the treatment of neurodegenerative diseases such as Alzheimer's Disease. The present disclosure provides, in part, methods for treating neurodegeneration or neurodegenerative diseases by administering compositions containing such Fc-containing polypeptides as well as methods for evaluating, identifying, and/or producing (e.g., manufacturing) such polypeptides for the treatment of neurodegeneration.
    Type: Application
    Filed: May 13, 2014
    Publication date: March 31, 2016
    Inventors: Thomas E. PROD'HOMME, Leona E. LING, Carlos J. BOSQUES, Anthony MANNING, Ganesh KAUNDINYA
  • N-ACETYLHEXOSAMINE-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS
    Publication number: 20160060675
    Abstract: The present invention provides methods of evaluating a glycoprotein preparation for the absence, presence or amount of an N-acetylhexosamine glycan, e.g., an N-acetylglucosamine glycan.
    Type: Application
    Filed: September 9, 2015
    Publication date: March 3, 2016
    Inventors: Nathaniel Washburn, Enrique Arevalo, Kevin Millea, Carlos J. Bosques, Jay Duffner, Brian Edward Collins
  • GALACTOSE-ALPHA-1, 3-GALACTOSE-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS DERIVED FROM CHO CELLS
    Publication number: 20160053292
    Abstract: The present invention provides methods of evaluating CHO cells.
    Type: Application
    Filed: August 21, 2015
    Publication date: February 25, 2016
    Inventors: Carlos J. Bosques, Jennifer Murphy, Hetal Sarvaiya, Nathaniel Washburn, Cuihua Liu, Xiao-Jin Xu