Abstract: The present disclosure relates generally to the analysis of immune checkpoint proteins involved in cancer. In particular, the present disclosure provides material and methods for determining abundance ratios of various immune checkpoint proteins (e.g., PD-1, PD-L1, and PD-L2) present in a biospecimen sample based on quantification of peak area using mass spectrometry analysis. The methods disclosed herein provide an alternative platform for diagnosing and treating cancer, especially in cases limited by ineffective antibody recognition.

Abstract: An implant-supported dental prosthesis, removal device for automatically removing the prosthesis, attachment piece for attaching the prosthesis to implants and an attachment bar for attaching the prosthesis to implants. The prosthesis comprises a compartment with a spacing member that can be actuated through a side opening by means of the device, for automatically removing the prosthesis. The device comprises a head with a first plunger configured for being introduced in the compartment and moving the first plunger in both directions to move the first plunger out when the spacer moves, causing removing the prosthesis, and when the first plunger moves in the opposite direction the head is extracted from the compartment. The attachment piece and bar for attaching the prosthesis respectively comprise a projection and a step to make it easier to remove the prosthesis.

Abstract: The “Electro-Mechanic device in Cylindrical Standard Soda Can Shape with inlet and outlet to connect to the water home tap, with Several inner compartments containing different materials, stream connected with chemicals that are filtering, changing and mixing the molecular composition of Running Water, Separating and joining elements in order to produce Cold Soda Drinks. Containing an integrated micro computer that regulates the temperature in each compartment and chemical processes, and a screen that transmits Audio and Video Commercials, where you can select the flavor of Soda you want and it confirms when the soda is high quality ready to pop and drink”.

Abstract: A local extremum of a function ƒ is determined by computing a Jacobian of ƒ at a test point x by adding an imaginary part to x and a Hessian of ƒ by adding two imaginary parts to a multicomplex copy of x and extracting a third imaginary part. Solving a system of equations defined by the Jacobian and Hessian yields a delta; the process is repeated until convergence. This method is used in each of a series of time intervals to compute an insulin-delivery amount for an insulin pump. ƒ is a model-predictive-control cost function; x is a set of successive candidate insulin delivery amounts beginning from a selected time interval. A system includes a glucose monitor and a controller using glucose measurement data therefrom to determine an insulin delivery amount for a time interval by minimizing ƒ; an insulin pump provides insulin corresponding to the delivery amount.

Abstract: A mobile phone mounting kit. The mobile phone mounting kit may comprise: a case, magnetic mounting platform, vehicle mounting arm, and air vent clips. The magnetic mounting platform may attach to a first end of the vehicle mounting arm, and the second end of the vehicle mounting arm may comprises a suction cup for attaching onto a surface. The magnetic mounting platform may comprises a magnet. The case may be configured to house a mobile phone and comprises one or more metal plates for attaching and securing to the magnet of the magnetic mounting platform. The case may comprises: a charging port, wires, charging contacts; and metal plates. The charging contacts may electrically communicate with a battery of the mobile phone. The charging port may mate and engage a connector of a power cable for charging the mobile phone by transferring an electrical current from the charging port to the charging contacts via the wires.

Abstract: An analyte meter with a test strip port that detects an orientation of a test strip inserted therein. A control circuit of the test meter is configured to apply a first predetermined analyte measurement signal to a test strip electrode in response to detecting a first orientation of the test strip, and a second predetermined analyte measurement signal to the same, or a different, electrode in response to detecting a second orientation of the test strip.

Abstract: Described and shown herein is simple dynamic model for insulin time-action profiles. Various aspects are suitable for implementation in an embedded system such as an insulin pump, or a handheld device such as a pump remote control. Various aspects can be used as an off-line modeling tool running on a smartphone to assist patients in their treatment, or can be used as part of a closed-loop control algorithm for an artificial pancreas.

Abstract: An analyte meter with a test strip port that detects an orientation of a test strip inserted therein. A control circuit of the test meter is configured to apply a first predetermined analyte measurement signal to a test strip electrode in response to detecting a first orientation of the test strip, and a second predetermined analyte measurement signal to the same, or a different, electrode in response to detecting a second orientation of the test strip.

Abstract: A local extremum of a function ƒ is determined by computing a Jacobian of ƒ at a test point x by adding an imaginary part to x and a Hessian of ƒ by adding two imaginary parts to a multicomplex copy of x and extracting a third imaginary part. Solving a system of equations defined by the Jacobian and Hessian yields a delta; the process is repeated until convergence. This method is used in each of a series of time intervals to compute an insulin-delivery amount for an insulin pump. ƒ is a model-predictive-control cost function; x is a set of successive candidate insulin delivery amounts beginning from a selected time interval. A system includes a glucose monitor and a controller using glucose measurement data therefrom to determine an insulin delivery amount for a time interval by minimizing ƒ; an insulin pump provides insulin corresponding to the delivery amount.

Abstract: The viscosities of 2-cyanoacrylate adhesive compositions are adjusted by the addition of polymeric thickeners to a preferred initial viscosity that will not increase significantly when sterilized by heating them at a temperature of no greater than about 110° C. for no more than about 120 minutes. Articles of manufacture are vials or squeezable tubes containing these compositions.

Abstract: Compounds of general formula (I) for the treatment of inflammatory processes involved in numerous diseases such as intestinal inflammatory diseases. The invention moreover refers to compounds included within such general formula and to the procedure of the obtainment thereof.

Abstract: A service provider unit automatically diagnoses problems in an Ethernet network that are associated with layers 1, 2, and/or 3 and determines whether there is a problem associated with an Ethernet gateway switch EGS. Further diagnostics can be performed to determine the layer, type, and/or location of the problem(s) based on whether there is a problem with the EGS. The diagnostic process followed depends on the types of problem(s) in the network. Once the problems have been diagnosed, an operator can be notified of the location and/or type of problem.

Abstract: A service provider unit automatically diagnoses problems in an Ethernet network that are associated with layers 1, 2, and/or 3 and determines whether there is a problem associated with an Ethernet gateway switch EGS. Further diagnostics can be performed to determine the layer, type, and/or location of the problem(s) based on whether there is a problem with the EGS. The diagnostic process followed depends on the types of problem(s) in the network. Once the problems have been diagnosed, an operator can be notified of the location and/or type of problem.

Abstract: The present invention provides a novel method of sterilizing 2-Cyanoacrylate ester compositions using a combination of chemical and irradiation means, and the resulting novel compositions. The combination of monomeric 2-Cyanoacrylate and irradiation have a lethal effect on microbials, rendering sterilized compositions when the appropriate sterilization condition is achieved and when the method is applied to 2-Cyanoacrylates in sealed containers. Samples are sterilized using electron beam at doses as low as about 1 to about 5 Kgy.

Abstract: The present invention refers to the use of phenolic compounds and their derivatives represented by formula I wherein R1 and R2 are selected from among: OH, OCOalkyl, or OCOalkenyl, and R3 is either H, OH, OCOalkyl or OCOalkenyl, wherein the alkyl or alkenyl chains present from 2 to 22 carbon atoms and wherein at least one OCOalkyl or OCOalkenyl group is present in the structure, for the prevention and treatment of cardiovascular, hepatic or renal diseases, as well as to their cosmetic applications, to compositions that include these compounds and to some novel phenolic compounds and derivatives.

Abstract: Discosed are a process for sterilization of cyanoacrylate adhesive compositions, the compositions, comprising 2-cyanoacrylate ester monomers, so produced and a method for assaying the effectiveness of the sterilization process. The process comprises heating the adhesive composition to from about 70° C. to about 140° C. for an effective amount of time. The effectiveness of the process can be assayed by disposing bacterial spores in the cyanoacrylate monomer, exposing the composition to a dry heat sterilization process, transferring the cyanoacrylate composition to a sterile aldose solution, transferring and exposing the sample to a nutrient medium which supports germination and growth of viable spores, incubating the samples, and determining the presence or absence of growth.

Abstract: The invention relates to the use of phenolic compounds and derivatives thereof for protection against neurodegenerative diseases, to compositions comprising these compounds, and to some novel phenolic compounds.

Abstract: The present invention refers to the use of phenolic compounds and their derivatives represented by formula I wherein R1 and R2 are selected from among: OH, OCOalkyl, or OCOalkenyl, and R3 is either H, OH, OCOalkyl or OCOalkenyl, wherein the alkyl or alkenyl chains present from 2 to 22 carbon atoms and wherein at least one OCOalkyl or OCOalkenyl group is present in the structure, for the prevention and treatment of cardiovascular, hepatic or renal diseases, as well as to their cosmetic applications, to compositions that include these compounds and to some novel phenolic compounds and derivatives.