Abstract: A lymphocytotoxic, but hematopoietic stem cell-sparing, high-dose amount of an oxazaphosphorine drug such as, for example, cyclophosphamide, administered post-transplantation can be used to reduce transplant rejection, including graft-versus-host-disease (GVHD). In some embodiments, the transplants are bone marrow transplants or hematopoietic stem cell transplants carried out for the treatment of hematologic disorders, including hematologic malignancies and non-malignant hematologic disorders. In some embodiments, the transplants are carried out for the treatment of hereditary hemoglobinopathies, such as sickle cell anemia and thalassemia.

Abstract: The present invention relates to methods of treating a cancer and in particular, a B-cell derived cancer, using a lymphocytotoxic but hematopoeitic cell sparing high-dose pulsed amount of an oxazaphosphorine drug in combination with immune therapeutics such as, for example, an autologous idiotypic vaccine and monoclonal antibodies that selectively bind B-cell specific antigens.

Abstract: The present invention relates to methods of treating an autoimmune disorder, using a lymphocytotoxic but hematopoeitic cell sparing high-dose pulsed amount of an oxazaphosphorine drug in combination with immune therapeutics such as, for example, monoclonal antibodies that selectively bind B-cell specific antigens.

Abstract: The present invention provides methods of identifying subjects that are suitable for high-dose cyclophosphamide treatment.

Abstract: The present invention relates to methods of inducing and maintaining an immune response against a B-cell idiotype in a subject using an autologous anti-idiotypic vaccine. In one embodiment, the immune response is induced and maintained for treatment of a B-cell derived malignancy selected from among non-Hodgkin's lymphoma. Hodgkin's lymphoma, chronic lymphocytic leukemia, multiple myeloma, and mantle cell lymphoma.

Abstract: The present invention relates to lidocaine derived compounds, which present less anesthetic activity than lidocaine itself, but with more anti-inflammatory and spasmolytic activity than said lidocaine as well as pharmaceutical compositions with at least one of these compounds or a salt of those as active principle and to the use of such compositions to treat, prevent or inhibit atopic diseases including asthma, rhinitis, allergic urticaria, chronic lung inflammation associated with eosinophilia, following the example of atopic asthma and chronic intestinal inflammation, as colitis for instance. The pharmaceutical composition may be available in spray form, solution, suspension, emulsion destinated to be applied by nebulization, or in any of the pharmaceutical available forms for oral or injectable use.

Abstract: The present invention provides for the use of an aqueous dispersion of particles composed of polymer and finely divided inorganic solid (aqueous composite-particle dispersion) as a binder in elastic coatings, such as paints, more particularly exterior architectural paints, comprising preparing the aqueous composite-particle dispersion by dispersely distributing ethylenically unsaturated monomers in an aqueous medium and carrying out polymerization by means of at least one free-radical polymerization initiator in the presence of at least one dispersely distributed, finely divided inorganic solid having an average particle diameter ?100 nm and at least one dispersant by the method of free-radically aqueous emulsion polymerization, and using as ethylenically unsaturated monomers a monomer mixture which comprises ethylenically unsaturated monomers A and optionally 0% to ?10% by weight of an ethylenically unsaturated monomer B containing an epoxide group (epoxide monomer).

Abstract: The present invention provides methods of treating subjects with an oxazaphosphorines, methods of identifying subjects that are suitable for oxazaphosphorine treatment, and systems for ensuring the safety and efficacy of a treatment that includes oxazaphosphorine administration.

Abstract: The present invention provides methods of treating subjects with an oxazaphosphorines, methods of identifying subjects that are suitable for oxazaphosphorine treatment, and systems for ensuring the safety and efficacy of a treatment that includes oxazaphosphorine administration.

Abstract: The present invention provides methods of treating subjects with an oxazaphosphorines, methods of identifying subjects that are suitable for oxazaphosphorine treatment, and systems for ensuring the safety and efficacy of a treatment that includes oxazaphosphorine administration.

Abstract: Various methods, devices and systems are described for providing distributed storage services. A data storage device is capable of initiating a communication session with an external entity such as a local host computer (and vice versa) coupled directly to the data storage device, a remote server computer, or directly with remote data storage devices with or without intervention by a local host computer.

Abstract: The present invention relates to lidocaine derived compounds, which present less anesthetic activity than lidocaine itself, but with more anti-inflammatory and spasmolytic activity than said lidocaine as well as pharmaceutical compositions with at least one of these compounds or a salt of those as active principle and to the use of such compositions to treat, prevent or inhibit atopic diseases including asthma, rhinitis, allergic urticaria, chronic lung inflammation associated with eosinophilia, following the example of atopic asthma and chronic intestinal inflammation, as colitis for instance. The pharmaceutical composition may be available in spray form, solution, suspension, emulsion destinated to be applied by nebulization, or in any of the pharmaceutical available forms for oral or injectable use.

Abstract: A high-capacity SIM card includes: memory having at least one partition and a memory controller configured: to control at least two modes of access to one partition of the partitions, only one of the modes being a currently-active mode; and to allow the currently-active mode to be operationally changed remotely. Preferably, the memory controller controls operability of reading data, writing data, erasing data, and/or executing code, according to the currently-active mode. Preferably, the memory controller also controls storage of data in the card based on access-control data delivered to the card. Preferably, the memory controller is configured to reversibly operationally change, for one partition, which mode is the currently-active mode. Preferably, the memory controller prohibits change of the currently-active mode by a host device of the card.

Abstract: An automatic pool cleaner is provided of the type for random travel over submerged floor and side wall surfaces of a swimming pool or the like to dislodge and collect debris. The pool cleaner includes an electric-powered traction drive system for rotatably driving cleaner wheels, and an electric-powered water management system including a water supply pump and related manifold unit for venturi-vacuuming and collection of settled debris within a porous filter bag. A directional control system including an on-board compass monitors turning movements of the pool cleaner during normal random travel operation, and functions to regulate the traction drive system in a manner to prevent, e.g., excess twisting of a conduit such as a power cable tethered to the pool cleaner.

Abstract: The invention relates to a device or matrix which can be used indiscriminately and intelligently to direct data flows (1) generated by various sources (2) towards one or more destination devices (3), the latter forming sources of new data flows, in a common interface environment (4). According to the invention, (i) source (2) refers to a tuner or another data transfer device capable of generating an MPEG-2 (Motion Picture Expert Group) data flow and compatibles, and (ii) destination device (3) refers to removable or integrated devices (5) within the system, which are capable of filtering, transforming or regenerating the contents of the original incoming flow, or devices which receive the resulting data flows (6). The purpose of the invention is to enable the indiscriminate routing of data from different sources (2) through the filtering modules (5) within one system (4), such that more than one application associated with the system can be handled simultaneously.

Abstract: 7The invention relates to a novel method of introducing a pay digital television mechanism whereby the content broadcaster or operator does not require a subscriber management infrastructure. According to the invention, the user is not committed to the operator but instead freely acquires content access time credit by means of an electronic transaction via a point of purchase8 on the Internet or a mobile phone message server. Moreover, the inventive system eliminates the need for customized validation and authentication information for each user to be sent permanently via the broadcast channel9 since said information is managed by means of a secure transfer mechanism when the credit is being purchased, with the time and content privileges acquired on the user platform being stored. The saving made in relation to the bandwidth is considerable when the number of users increases. 7 This translation, which appeared in the original, is acceptable, except where noted. 8 “Point of purchase” should be “point of sale.

Abstract: The hand-held implement has a fixed motor and a hand-held appliance part on which a tool is mounted. The hand-held appliance part is connected to the fixed motor via a driving shaft and a Bowden cable only. The hand-held appliance part has a slide, moving which operates the Bowden cable. The fixed motor is thereby switched on and off and controlled, its output being adjusted according to the amount of draft applied to the Bowden cable. To produce high torque, the hand-held appliance part incorporates a worm gear pair wherein the driving shaft leading to the appliance part drives a worm that engages with a worm wheel, the driven axle of which projects from the housing, enabling a large number of different tools to be mounted on the driven axle.