Patents by Inventor Carlton D. Donald

Carlton D. Donald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
    Patent number: 8318692
    Abstract: Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: November 27, 2012
    Inventor: Carlton D. Donald
  • TARGETING EN2, PAX2, AND/OR DEFB1 FOR TREATMENT OF PROSTATE CONDITIONS
    Publication number: 20120157508
    Abstract: The present invention relates to methods and compositions for treating a prostate condition in a subject. The method comprises administering to the subject a subject effective amount of a pharmaceutical composition having a first agent that inhibits EN2 expression and/or EN2 activity and a second agent that inhibits PAX2 expression and/or PAX2 activity. The pharmaceutical composition may further comprise a third agent that enhances DEFB1 expression or activity.
    Type: Application
    Filed: December 5, 2011
    Publication date: June 21, 2012
    Applicant: PHIGENIX, INC.
    Inventor: CARLTON D. DONALD
  • COMPOSITIONS AND METHODS FOR MONITORING AND DETECTING CANCEROUS CONDITIONS
    Publication number: 20120071347
    Abstract: A method for monitoring or detecting a prostate condition in a subject comprises determining Engrailed-2 (EN2) gene, Paired Box 2 (PAX2) gene, and/or ? defensin-1 (DEFB1) gene expression levels in a biological sample from the subject. The expression levels of EN2, PAX2 and/or DEFB1 gene are correlated with cancerous, pre-cancerous, or non-cancerous prostate conditions.
    Type: Application
    Filed: December 5, 2011
    Publication date: March 22, 2012
    Applicant: PHIGENIX, INC.
    Inventor: Carlton D. DONALD
  • COMPOSITIONS AND METHODS FOR DIAGNOSING, TREATING, AND PREVENTING PROSTATE CONDITIONS
    Publication number: 20120058130
    Abstract: Disclosed are compositions and methods for diagnosing, preventing, and treating prostate cancer and prostate intraepithelial neoplasia (PIN).
    Type: Application
    Filed: October 26, 2011
    Publication date: March 8, 2012
    Applicant: PHIGENIX, INC.
    Inventor: Carlton D. DONALD
  • Compositions and methods for diagnosing, treating, and preventing prostate conditions
    Patent number: 8088603
    Abstract: Disclosed are compositions and methods for diagnosing, preventing, and treating prostate cancer and prostate intraepithelial neoplasia (PIN).
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: January 3, 2012
    Assignee: Phigenix, Inc.
    Inventor: Carlton D. Donald
  • TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER
    Publication number: 20110318338
    Abstract: The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: May 26, 2011
    Publication date: December 29, 2011
    Applicant: PHIGENIX, INC.
    Inventor: Carlton D. DONALD
  • Targeting PAX2 for the treatment of breast cancer
    Patent number: 8080534
    Abstract: The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the certain embodiments, the method of inhibiting expression of PAX2 is to administrate the subject a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 or by increasing expression of DEFB1 is also provided.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: December 20, 2011
    Assignee: Phigenix, Inc
    Inventor: Carlton D. Donald
  • TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER
    Publication number: 20110243937
    Abstract: The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: May 26, 2011
    Publication date: October 6, 2011
    Applicant: PHIGENIX, INC.
    Inventor: Carlton D. DONALD
  • TARGETING PAX2 FOR THE INDUCTION OF DEFB1-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY
    Publication number: 20110236403
    Abstract: Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: January 21, 2011
    Publication date: September 29, 2011
    Applicant: Medical University of South Carolina
    Inventor: Carlton D. DONALD
  • COMPOSITIONS AND METHODS FOR DIAGNOSING, TREATING, AND PREVENTING PROSTATE CONDITIONS
    Publication number: 20110229492
    Abstract: Disclosed are compositions and methods for diagnosing, preventing, and treating prostate cancer and prostate intraepithelial neoplasia (PIN).
    Type: Application
    Filed: February 10, 2011
    Publication date: September 22, 2011
    Applicant: PHIGENIX, INC.
    Inventor: Carlton D. DONALD
  • TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER
    Publication number: 20110229467
    Abstract: The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: April 29, 2011
    Publication date: September 22, 2011
    Applicant: PHIGENIX, INC.
    Inventor: Carlton D. DONALD
  • TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER
    Publication number: 20110229468
    Abstract: The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: April 29, 2011
    Publication date: September 22, 2011
    Applicant: PHIGENIX, INC.
    Inventor: Carlton D. DONALD
  • TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER
    Publication number: 20110223161
    Abstract: The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: May 24, 2011
    Publication date: September 15, 2011
    Applicant: PHIGENIX, INC.
    Inventor: Carlton D. Donald
  • TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER
    Publication number: 20110223162
    Abstract: The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB 1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: May 24, 2011
    Publication date: September 15, 2011
    Applicant: PHIGENIX, INC.
    Inventor: Carlton D. Donald
  • TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER
    Publication number: 20110217299
    Abstract: The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: March 17, 2011
    Publication date: September 8, 2011
    Inventor: Carlton D. DONALD
  • TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER
    Publication number: 20110212089
    Abstract: The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: March 18, 2011
    Publication date: September 1, 2011
    Applicant: Phigenix, Inc.
    Inventor: Carlton D. DONALD
  • TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER
    Publication number: 20110206666
    Abstract: The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: March 25, 2011
    Publication date: August 25, 2011
    Applicant: PHIGENIX, INC.
    Inventor: Carlton D. DONALD
  • TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER
    Publication number: 20110206665
    Abstract: The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: March 25, 2011
    Publication date: August 25, 2011
    Applicant: PHIGENIX, INC.
    Inventor: Carlton D. DONALD
  • TARGETING PAX2 FOR THE INDUCTION OF DEFB1-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY
    Publication number: 20110177100
    Abstract: Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: January 13, 2011
    Publication date: July 21, 2011
    Applicant: MEDICAL UNIVERSITY OF SOUTH CAROLINA
    Inventor: Carlton D. DONALD
  • TARGETING PAX2 FOR THE INDUCTION OF DEFB1-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY
    Publication number: 20110178162
    Abstract: Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: January 13, 2011
    Publication date: July 21, 2011
    Applicant: MEDICAL UNIVERSITY OF SOUTH CAROLINA
    Inventor: Carlton D. DONALD