Patents by Inventor Carlton D. Donald

Carlton D. Donald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETING PAX2 FOR THE INDUCTION OF DEFB1-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY
    Publication number: 20110177101
    Abstract: Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: January 20, 2011
    Publication date: July 21, 2011
    Applicant: MEDICAL UNIVERITY OF SOUTH CAROLINA
    Inventor: Carlton D. DONALD
  • TARGETING PAX2 FOR THE INDUCTION OF DEFB1-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY
    Publication number: 20110177075
    Abstract: Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: January 19, 2011
    Publication date: July 21, 2011
    Applicant: Medical University of South Carolina
    Inventor: Carlton D. DONALD
  • Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
    Patent number: 7964577
    Abstract: Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Grant
    Filed: October 16, 2006
    Date of Patent: June 21, 2011
    Inventor: Carlton D. Donald
  • TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER
    Publication number: 20100209421
    Abstract: The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the certain embodiments, the method of inhibiting expression of PAX2 is to administrate the subject a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 or by increasing expression of DEFB1 is also provided.
    Type: Application
    Filed: February 18, 2010
    Publication date: August 19, 2010
    Applicant: PHIGENIX, INC.
    Inventor: Carlton D. DONALD
  • TARGETING PAX2 FOR THE INDUCTION OF DEFBI-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY
    Publication number: 20100196450
    Abstract: Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
    Type: Application
    Filed: October 16, 2006
    Publication date: August 5, 2010
    Inventor: Carlton D. Donald
  • COMPOSITIONS AND METHODS FOR DIAGNOSING, TREATING, AND PREVENTING PROSTATE CONDITIONS
    Publication number: 20100029560
    Abstract: Disclosed are compositions and methods for diagnosing, preventing, and treating prostate cancer and prostate intraepithelial neoplasia (PIN).
    Type: Application
    Filed: January 16, 2008
    Publication date: February 4, 2010
    Applicant: PHIGENIX, INC
    Inventor: Carlton D. Donald
  • DETECTING PAX2 FOR THE DIAGNOSIS OF BREAST CANCER
    Publication number: 20100029504
    Abstract: A method for monitoring breast conditions in a subject is disclosed. The method comprises determining a Paired Box 2 gene-to-beta defensin-1 gene (PAX2-to-DEFB1) expression ratio (the “Donald Predictive Factor” or “DPF”) in cells obtained from the breast of the subject, wherein the PAX2-to-DEFB1 expression ratio is correlated with breast conditions. Also disclosed is a kit for monitoring breast conditions and determining drug resistance.
    Type: Application
    Filed: August 24, 2009
    Publication date: February 4, 2010
    Applicant: PHIGENIX, INC.
    Inventor: Carlton D. DONALD