Patents by Inventor Carmelo Gandolfi

Carmelo Gandolfi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 15-Cycloaliphatic derivatives of 13,14-didehydro-carboprostacyclins and process for their preparation
    Patent number: 4514396
    Abstract: 13, 14 didehydro-15 cyclic prostacyclins have been prepared.
    Type: Grant
    Filed: September 28, 1983
    Date of Patent: April 30, 1985
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Nicola Mongelli, Carmelo Gandolfi
  • Fluoro-prostaglandins and process for their preparation
    Patent number: 4425359
    Abstract: Fluoro-prostaglandin compounds are disclosed, such as, for instance, 18,19,20-trinor-17-cyclohexyl-16(S,R)-fluoro-PGF.sub.2.alpha.. The fluoro-prostaglandins of the present invention have the same therapeutical uses as natural prostaglandins, but have the advantage of being resistant to the enzyme 15-prostaglandin dehydrogenase, and also exhibit a more selective therapeutical action. Certain of the compounds of the present invention exhibit very favorable luteolytic and antiulcer activity.
    Type: Grant
    Filed: August 14, 1981
    Date of Patent: January 10, 1984
    Assignee: Farmitalia Carlo Erba
    Inventors: Renato Pellegata, Carmelo Gandolfi
  • Fluoro-prostaglandins and process for their preparation
    Patent number: 4414407
    Abstract: 16-Fluoro-13,14-dehydro-PG.sub.2 series have been prepared, and their pharmaceutical use.
    Type: Grant
    Filed: December 7, 1981
    Date of Patent: November 8, 1983
    Assignee: Farmitalia Carlo Erba
    Inventors: Renato Pellegata, Carmelo Gandolfi
  • .omega.-Nor-cycloalkyl-13,14-dehydro-prostaglandins and process for their preparation
    Patent number: 4361577
    Abstract: .omega.-Nor-cycloalkyl-13,14-dehydro-prostaglandin compounds, specifically 5c-9-oxo-11.alpha.,15S-dihydroxy-20,19,18-tirnor-17-cyclohexyl-prost-5-en- 13-ynoic acid, the esters and salts thereof, having antiulcer and luteolytic activity, are disclosed.
    Type: Grant
    Filed: February 2, 1979
    Date of Patent: November 30, 1982
    Assignee: Carlo Erba - S.p.A.
    Inventors: Carmelo Gandolfi, Renato Pellegata, Roberto Ceserani, Maria M. Usardi
  • Cyclopenta[b]furan-2-one and -2-ol intermediates for 16-fluoro-13,14-didehydro-prostaglandins
    Patent number: 4338249
    Abstract: 16-Fluoro-prostaglandins and pharmaceutical compositions containing the same are prepared. They are useful, for example, as anti-ulcer agents.
    Type: Grant
    Filed: April 7, 1980
    Date of Patent: July 6, 1982
    Assignee: Farmitalia Carlo Erba
    Inventors: Renato Pellegata, Carmelo Gandolfi
  • Fluoro-prostaglandins
    Patent number: 4338332
    Abstract: 16-Fluro-13, 14-dehydro-PG.sub.2 series compounds have been prepared.
    Type: Grant
    Filed: September 21, 1978
    Date of Patent: July 6, 1982
    Assignee: Farmitalia Carlo Erba
    Inventors: Renato Pellegata, Carmelo Gandolfi
  • Certain PGI.sub.1 compounds and their pharmaceutical composition and methods
    Patent number: 4328240
    Abstract: 2-oxa-bicyclic prostaglandins are provided, together with methods for their preparation and pharmaceutical and veterinary compositions containing same. The compounds have a wide range of pharmacological utilities, such as hypotensive agents, vasodilatory agents, and anti-aggregating agents.
    Type: Grant
    Filed: July 28, 1978
    Date of Patent: May 4, 1982
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Alessandro Andreoni, Angelo Fumagalli, Franco Faustini, Roberto Ceserani, Maria M. Usardi
  • 15-Epi-prostacyclin and analogous prostacyclins
    Patent number: 4321205
    Abstract: 15-Epi-Prostacyclin derivatives and compositions containing them having numerous pharmaceutical and veterinary utilities including, for example, anti-aggregating activity and anti-thrombolytic activity. Methods for preparing and using the compounds are also disclosed.
    Type: Grant
    Filed: April 18, 1980
    Date of Patent: March 23, 1982
    Assignee: Farmitalia Carlo Erba, S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Allesandro Andreoni, Angelo Fumagalli, Franco Fanstini, Roberto Ceserani
  • Fluoro-prostaglandins and process for their preparation
    Patent number: 4320143
    Abstract: Fluoro-prostaglandin compounds are disclosed, such as, for instance, 18,19,20-trinor-17-cyclohexyl-13-14-dehydro-16(S,R)-fluoro-PGF.sub.2.alpha ..The fluoro-prostaglandins of the present invention have the same therapeutical uses as natural prostaglandins, but have the advantage of being resistant to the enzyme 15-prostaglandin dehydrogenase, and also exhibit a more selective therapeutical action. Certain of the compounds of the present invention exhibit very favorable luteolytic and antiulcer activity.
    Type: Grant
    Filed: February 2, 1979
    Date of Patent: March 16, 1982
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Renato Pellegata, Carmelo Gandolfi
  • 9-Deoxy-9A-methylene isosteres of PGI.sub.2 and process for their preparation
    Patent number: 4307112
    Abstract: 9-deoxy-9A-methylene-isosteres of PGI.sub.2, including processes for their preparation and pharmaceutical and veterinary compositions containing same, are disclosed. The compounds are useful as therapeutic agents, for example as anti-aggregating agents, disaggregating agents, and as vasodilators.
    Type: Grant
    Filed: February 26, 1980
    Date of Patent: December 22, 1981
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, William Fava, Angelo Fumagalli, Franco Faustini, Roberto Ceserani
  • Bicyclic prostaglandins and process for their preparation
    Patent number: 4303670
    Abstract: Bicyclic prostaglandins and pharmaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities, including, for example, hypotensive, vasodilatory, anti-aggregating, luteolytic, and cytoprotective activities. Processes for preparing the compounds and compositions are also disclosed.
    Type: Grant
    Filed: April 13, 1979
    Date of Patent: December 1, 1981
    Assignee: Farmitalia Carlo Erba
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Alessandro Andreoni, Angelo Fumagalli, Franco Faustini, Roberto Ceserani, Maria M. Usardi
  • Pharmaceutically useful 5,6-saturated PGI compounds
    Patent number: 4297368
    Abstract: Bicyclic prostaglandins and pharamaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities, including, for example, hypotensive, vasodilatory, anti-aggregating, luteolytic, and cytoprotective activities. Processes for preparing the compounds and compositions are also disclosed.
    Type: Grant
    Filed: June 29, 1978
    Date of Patent: October 27, 1981
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Alessandro Andreoni, Angelo Fumagalli, Franco Faustini, Roberto Ceserani, Maria M. Usardi
  • 13,14-Dehydro-11-deoxy-prostaglandins and process for their preparation
    Patent number: 4293705
    Abstract: Novel optically active 13,14-dehydro-11-deoxy-prostaglandins having a phenyl or substituted-phenyl group on the lower side chain are disclosed.
    Type: Grant
    Filed: February 19, 1980
    Date of Patent: October 6, 1981
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Renato Pellegata, Franco Faustini, Angelo Fumagalli
  • Certain 15-epi-prostacyclins
    Patent number: 4285966
    Abstract: The present invention relates to 15-epi-derivatives of prostacyclin and its analogs, to a process for their preparation and to pharmaceutical and veterinary compositions containing them.
    Type: Grant
    Filed: October 30, 1978
    Date of Patent: August 25, 1981
    Assignee: Farmitalia Carlo Erba, S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Alessandro Andreoni, Angelo Fumagalli, Franco Faustini, Roberto Cesarani
  • Bicyclic prostaglandins
    Patent number: 4277491
    Abstract: Bicyclic prostaglandins and pharmaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities including, for example, hypotensive, vasodilatory, anti-aggregating, luteolytic, and cytoprotective activities. Processes for preparing the compounds are also disclosed.
    Type: Grant
    Filed: December 1, 1978
    Date of Patent: July 7, 1981
    Assignee: Farmitalia Carlo Erba, S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Alessandro Andreoni, Angelo Fumagalli, Franco Faustini, Roberto Ceserani, Maria M. Usardi
  • Bicyclic prostaglandins
    Patent number: 4271183
    Abstract: Bicyclic prostaglandins and pharmaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities including, for example, hypotensive, vasodilatory, anti-aggregating, luteolytic, and cytoprotective activities. Processes for preparing the compounds and compositions are also disclosed.
    Type: Grant
    Filed: April 13, 1979
    Date of Patent: June 2, 1981
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Alessandro Andreoni, Angelo Fumagalli, Franco Faustini, Roberto Ceserani, Maria M. Usardi
  • Bicyclic prostaglandins
    Patent number: 4271184
    Abstract: Bicyclic prostaglandins and pharmaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities including, for example, hypotensive, vasodilatory, antiaggregating, luteolytic, and cytoprotective activities. Processes for preparing the compounds and compositions are also disclosed.
    Type: Grant
    Filed: November 30, 1979
    Date of Patent: June 2, 1981
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Alessandro Andreoni, Angelo Fumagalli, Franco Faustini, Roberto Ceserani, Maria M. Usardi
  • Bicyclic prostaglandins and process for their preparation
    Patent number: 4262016
    Abstract: Bicyclic Prostaglandins and pharmaceutical and veterinary compositions containing them, having numerous pharmaceutical and veterinary utilities, including for example hypotensive, vasodilatory, anti-aggregating, and anti-thrombotic activities. Methods for preparing the compounds and compositions are also disclosed.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: April 14, 1981
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Alessandro Andreoni, Angelo Fumagalli, Franco Faustini, Roberto Ceserani, Maria M. Usardi
  • Certain 13,14-didehydro-PGI.sub.1 compounds
    Patent number: 4259244
    Abstract: Bicyclic prostaglandins having numerous pharmaceutical and veterinary utilities including, for example, use as hypotensive, vasodilatory, anti-aggregating, cytoprotective, and bronchodilatory agents. Pharmaceutical and veterinary compositions comprising the compounds in combination with pharmaceutically and/or veterinarily acceptable carriers and/or diluents are also disclosed.
    Type: Grant
    Filed: April 13, 1979
    Date of Patent: March 31, 1981
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Alessandro Andreoni, Angelo Fumagalli, Franco Faustini, Roberto Ceserani, Maria M. Usardi
  • Bicyclic prostaglandins and process for their preparation
    Patent number: 4254137
    Abstract: Bicyclic prostaglandins and pharmaceutical and veterinary compositions containing them, having numerous pharmaceutical and veterinary utilities, including for example hypotensive, vasodilatory, anti-aggregating, and anti-thrombotic activities. Methods for preparing the compounds and compositions are also disclosed.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: March 3, 1981
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Alessandro Andreoni, Angelo Fumagalli, Franco Faustini, Roberto Ceserani, Maria M. Usardi