Abstract: Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.

Abstract: Devices and methods are described for occluding the left atrial appendage (LAA). The device excludes the LAA from blood flow to prevent blood from clotting within the LAA and subsequently embolizing, particularly in patients with atrial fibrillation. The implantable device is delivered via transcatheter delivery into the LAA and secured within the LAA. The implant comprises an expandable and compliant frame and an expandable and conformable tubular foam body. The device may have a thromboresistant cover at a proximal end. The frame may have recapture struts inclining radially outwardly from a central hub. The frame may have axially extending side wall struts, with adjacent pairs of side wall struts joined at one or more apexes. Anchors extend from the frame and into the foam to engage tissue.

Abstract: A modular satellite testing platform system having an upper and a lower member along with a plurality of support members, intermediate members, and lower bar members that are interconnected to the upper member and the lower member. The system further includes a plurality of shelf members that are attached to the support members. The satellite also includes a plurality of bottom cover members that are attached to the lower member by a plurality of hinge members that allow the cover members to selectively rotated about an axis to be rotatably translated between an opened position and a closed position. The system yet further includes a thermal control system to allow maintaining the thermals of the satellite as desired.

Abstract: Systems and methods for tuning hyperparameters for a machine learning model using a challenger champion model are described. A set of challenger configurations are generated based on a hyperparameter for tuning and a subset of the set of challenger configurations are scheduled for evaluation based on a loss function. A loss value derived from the loss function for the challenger configurations is compared to a loss value derived from the loss function for a champion configuration, and the champion configuration is replaced with the challenger configuration based on the comparison of the loss value derived from the loss function for the challenger configuration and the loss value derived from the loss function for the champion configuration. When the champion is replaced, a new set of challenger configurations is generated based on the new champion configuration.

Abstract: A deep-learning method and systems for analyzing optical coherence tomography (OCT) images based on a convolutional neural network are provided. The method includes extracting a feature from one or more three-dimensional OCT volumetric scan images and classifying the OCT images with respect to diabetic macular edema (DME) based on results the feature extracted. The step of extracting a feature from one or more three-dimensional OCT volumetric scan images is performed by a neural network such as a neural network based on a ResNet-34 architecture. The method can further include extracting a feature from one or more two-dimensional (2D) OCT B-scan images and classifying the OCT images with respect to DME based on results of the 2D feature extracted. The step of extracting a feature from one or more 2D OCT B-scan images is performed by a neural network such as a neural network based on a ResNet-18 architecture.

Abstract: One variation of a method for communicating state, intent, and context of an autonomous vehicle includes: at a first time, displaying a first icon representing a current state of a vehicle on a rear-facing visual display arranged on the vehicle; navigating toward an intersection; at a second time, detecting a state of the intersection ahead of the vehicle; rendering a second icon representing the state of the intersection at the second time on the rear-facing visual display; detecting a change in the state of the intersection at a third time succeeding the second time; selecting a next navigation action for the vehicle responsive to the change in the state of the intersection at the third time; prior to executing the next navigation action, rendering a third icon representing the next navigation action on the rear-facing visual display; and autonomously executing the next navigation action.

Abstract: The present application relates to substituted coumarin derivatives and their uses as fluorescent labels. These compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.

Abstract: Various methods and processes, apparatuses/systems, and media for constrained and loan pricing are disclosed. An optimization engine provides daily pricing vector for each loan pricing segment. The daily pricing output per segment (“vectors”) flows into an assessment process to determine a profit and loss (PnL) calculation and a constraints score. The resulting vectors (along with the PnL calculation and constraint scores) are stored in a tuple store. A processor updates surrogate parameters with new tuple store data points; evaluates an acquisition function on the surrogate parameters to find the next query subsidy vector; utilizes this expanded set of vectors and runs them back through the PnL calculation and generates constraint scores; and reports sufficiently subsidy vectors to a pricing team for final subsidy selection.

Abstract: A demosaicing method is disclosed as being applied to an initial image in order to obtain a demosaiced image, enabling an improved demosaicing due to the fact that it includes a noise variance stabilization transformation, for each reference patch: a determination of a set of similar patches, a determination of a covariance matrix for said set of similar patches, and for each similar patch, a calculation of estimates of the interpolated spectral bands according to a block-based deconstruction of the covariance matrix as a function of the phasing, a determination of the interpolated spectral bands by an aggregation of estimates of the interpolated spectral bands, and an inverse transformation of the stabilization transformation.

Abstract: A method for manufacturing a relaxed epitaxial InGaN layer from a GaN/InGaN substrate comprising the following steps: a) providing a first stack comprising a GaN or InGaN layer to be porosified and a barrier layer, b) transferring the GaN or InGaN layer to be porosified and the barrier layer to a porosification support, in such a way as to form a second stack, c) forming a mask on the GaN or InGaN layer to be porosified, d) porosifying the GaN or InGaN layer through the mask, e) transferring the GaN or InGaN porosified layer and the barrier layer to a support of interest, f) forming an InGaN layer by epitaxy on the barrier layer, whereby a relaxed epitaxial InGaN layer is obtained.

Abstract: Aspects of the disclosure include light-emitting diodes (LEDs) formed without phosphor deformation during the lamination process. An exemplary method can include forming one or more LEDs on a backplane and forming a protective layer on the backplane. The protective layer can be patterned to define one or more trenches exposing sidewalls of a respective one LED of the one or more LEDs and a surface of the backplane. Each trench can be filled with a color-shifting coating. The method includes laminating the one or more LEDs, the backplane, the protective layer, and the color-shifting coating between one or more inner reinforcing layers and one or more outer layers to define a display.

Abstract: An endless neck tie. In one embodiment an endless loop of fabric of varying width includes a relatively narrow segment providing a neckband, and a first blade and a second blade of variable width extending in opposite directions along the loop and away from the neckband. At least a first transition region, between the blades or between the neck band and the blades, is of such narrow width relative to the blade width that the transition region accepts at least a first knot which defines a constricted region of the endless neck tie between the neck band and the blades.

Abstract: An optoelectronic device, comprising a stack including a plurality of light-emitting diodes disposed at a distance from one another, and a plurality of electrically conductive terminals arranged between the diodes, and a light confinement layer extending over the stack and comprising reflective walls defining between them, spaces located to the right of each diode. Further, the confinement layer includes the porous alumina in at least one of the spaces, the porous alumina having, in at least one space, preferably in at least two of the spaces, even in each space, from among the at least some spaces, at least two open pores on a first face of the confinement layer which is located opposite the stack. The optical crosstalk phenomena are advantageously reduced.

Abstract: A copper alloy that does not contain beryllium and has a 0.2% offset yield strength of at least 80 ksi and an electrical conductivity of at least 48% IACS is disclosed. The copper alloy contains nickel, silicon, chromium, manganese, zirconium, and balance copper. The alloy is prepared by cold working, solution annealing, and aging. The alloy can be used, for example, as a heat sink.

Abstract: This invention relates to kits including novel oral food challenge meal formulations. In particular, the invention also relates to kits including novel oral food challenge meal formulations, wherein the placebo dose formulation is indistinguishable from non-placebo dose formulations.

Abstract: Techniques for coupling fields to exotic matter at a particular location to identify, or determine the current date/time at that location, are provided. Example techniques include capturing sensor data indicating a decay rate associated with a radioactive material at the location over a period of time; analyzing the sensor data indicating the decay rate associated with the radioactive material at the location over the period of time in order to identify a peak decay rate over the period of time and a point in time, over the period of time, at which the peak decay rate occurred; and determining one or more of: a current time at the particular location, a current date at the location, or an identification of the location, based on one or more of: the peak decay rate or the point in time over the period of time at which the peak decay rate occurred.

Abstract: The disclosure provides RNA vaccines for seasonal influenza virus as well as methods of using the vaccines.

Abstract: Antibody formulations and methods useful for treatment of patients with AL amyloidosis.

Abstract: A modular satellite system is provided comprising a main body member, one or more controllers, a communication system, a datastore, a power unit, and one or more orbital cameras. The controller(s) may be operable to perform a mission instruction. The communication system may be in communication with the controller(s) and with a client terminal. The datastore may store data accessible by the controller(s). The orbital camera(s) may be operable to capture one or more image(s) associated with the mission instruction, which may be defined as captured image(s). The controller(s) may be operable to detect and identify one or more predetermined object(s) in the one or more captured image(s). The controller(s) may generate a mission analytics packet, and the controller(s) may be operable to transmit the mission analytics packet to the client terminal.