Abstract: Optimized chimeric antigen receptors (CARs) targeting glypican-2 (GPC2) and having a CD28 hinge region and a CD28 transmembrane domain are described. The antigen-binding domain of the disclosed CARs is derived from GPC2-specific antibody CT3 or humanized versions thereof. The optimized CARs also include an intracellular co-stimulatory domain and an intracellular signaling domain. Immune cells or induced pluripotent stem cells expressing the optimized CARs can be used to treat GPC2-positive solid tumors, such as neuroblastoma.

Abstract: A glass comprising a coefficient of thermal expansion (CTE) of 70×10?7/° C. or less, a liquidus viscosity of at least 150 kP, and Li2O in an amount of 0.1 wt. % or less, wherein the glass is ion-exchangeable. A glass, comprising SiO2 in an amount of 64-73 wt. %, Al2O3 in an amount of 7-15 wt. %, B2O3 in an amount of 9-11 wt. %, Na2O in an amount of 6-9.5 wt. %, K2O in an amount of 0.5-3 wt. %, CaO in an amount of at least 0.05 wt. %, and Li2O in an amount of less than 0.1 wt. %, wherein a weight ratio of Na2O/Al2O3 is less than or equal to 0.9. A method of recycling glass, the method comprising heating a composition to form a melt, the composition comprising glass cullet in an amount of at least 60 wt. %, and raw materials in an amount of 40 wt. % or less.

Abstract: A system is provided that includes a memory device and one or more processors coupled with the memory device. The one or more processors are configured to determine, autonomously, one or more phases in a surgical procedure based on a video stream of the surgical procedure. The one or more processors are further configured to identify one or more usages of a surgical instrument used during the surgical procedure. The one or more processors are configured to display a chart of the one or more usages. The chart divides the one or more usages according to the one or more phases respectively, and a representation of each of the one or more usages indicates a duration of each usage.

Abstract: Techniques are described for failing over from a primary database to the replicated logical database of the primary database. Techniques are also described for the client-side object references to be preserved when failing over to the logical replica database, for AS OF and other queries preserved, and for versioning of checksums, signatures and structures across logical replicas.

Abstract: The present invention relates to the treatment of subjects having a CD20-positive cell proliferative disorder. More specifically, the invention pertains to the treatment of subjects having a CD20-positive cell proliferative disorder by administering a combination of mosunetuzumab and polatuzumab vedotin.

Abstract: A packing system for safely packing fragile household item for moving or storage. The packing system provides a number of packing devices which include a pair of ends bridged by a central portion, and a pair of elastic skirts along the central portion, all of which form a cup-like shape for receiving the fragile household item. A variety of sizes of the packing devices could be combined within a single kit. They could be color coded. An embodiment of the invention employs unused diapers as the packing devices. These could be donated or otherwise procured.

Abstract: A radio-frequency identification (RFID) fluid connection, including a tube or hose, the tube or hose including a radially outward facing surface, a RFID assembly or label connected the radially outward facing surface, including a RFID tag, and at least one contact electrically connected to the RFID tag.

Abstract: Wearable uroflowmetry systems having wearable uroflowmeters are disclosed. A disclosed example uroflowmetry system comprises a wearable uroflowmeter including: a funnel portion having an end configured to secure the funnel portion against a person, an outlet opposite the end, and a funnel configured to capture urine excreted by the person when the end is secured against the person, and to direct the captured urine into the outlet; a fluid passage portion having an opening configured to receive the urine from the outlet of the funnel portion, and a fluid channel to pass the received urine along a length of the fluid passage portion; and a measuring portion having a sensor in the fluid channel configured to collect one or more measurements of the urine as the urine passes the sensor, the measurements representative of at least one of a property of the urine, or a flow characteristic of the urine.

Abstract: A method of evaluating spinal cord stimulation (SCS), comprising obtaining neural response data generated by a spinal cord stimulator, where the neural response data describes one or more neural signals evoked in the spinal cord of a patient by applying diagnostic stimuli. One or more evoked compound action potentials (ECAPs) associated with the respective one or more neural signals are detected. The one or more detected ECAPs are processed to generate one or more evaluation metrics, and the one or more evaluation metrics are used to generate a confidence score indicating a degree of effectiveness of SCS on the patient.

Abstract: A method for producing a cutting tool including a tool body including a hard coating, the method comprising: applying the hard coating to the tool body at least in an area of a cutting edge, a flank, and a chipping surface; depositing the hard coating on a surface of the tool body, of the cutting tool in an area of the cutting edge, of the flank adjacent to the cutting edge, and of the chipping surface adjacent to the cutting edge; sharpening the cutting edge that is provided with the hard coating and that forms a dull rounded edge by partially removing the hard coating in the area of the flank of the cutting edge by laser machining to form a sharpened cutting edge so that an angle ? is enclosed between a first geometric plane in which a surface of the tool body extends.

Abstract: An explosive booster for initiating, and thus causing detonation of, a bulk explosive, includes a hollow body comprising a base member and a sidewall projecting from the base member. The body defines an interior space between the base member and the sidewall for containing a detonable booster formulation in use. A hollow elongate initiator locating formation projects longitudinally into the interior space at least from the base member and defines an initiator channel that is open through the base member, for locating an explosive initiator in initiating proximity relative to a detonable booster formulation contained in the interior space in use. The initiator channel extends longitudinally along a central longitudinal axis thereof that is radially spaced from, and parallel to, a central longitudinal axis along which the interior space longitudinally extends.

Abstract: Image sensor systems are disclosed that allow for charge transfer between pixels of a group included in a pixel array with a single digital readout of the accumulated charge from the group. Each of the pixels within a given group includes a photodetector. One or more pump gates are arranged between adjacent pixels of the given group to allow charge to be pumped from one pixel to the next in a serial fashion within the group. A readout circuit that includes at least a transfer gate and a capacitor may be coupled to a final pixel of the group to receive the accumulated charge and generate a photodetector signal (based on the accumulated charge) that can be amplified via a source follower component and ultimately read out to a column amplifier.

Abstract: A method for manufacturing a detector of a first and a second incident ionizing radiation including determining the abscissa em of a point of intersection between a first and a second curve, with the first and second curves representing the evolution of the number of photons or electrical charges generated per second by a transducing material as a function of the total thickness of an amplifying material when the transducing material is irradiated, through this thickness of transducing material, by the first and second incident ionizing radiation, respectively; then selecting the total thickness of amplifying material between 0.9 em and 1.1 em and producing the detector with the selected thickness of amplifying material.

Abstract: Overlapping functions called in robotic process automation scripts may be used to create new efficiencies in an IT infrastructure. For example, the overlaps may be used to identify code modification impact in the IT infrastructure, may be used to remediate duplication of coding efforts across silos in an organization, and may be merged to create new efficiencies in code/script storage and/or sustaining efforts.

Abstract: A magnetic resonance (MR) imaging system, comprising a magnetics system having a plurality of magnetics components configured to produce magnetic fields for performing magnetic resonance imaging, and a sensor configured to detect electromagnetic interference conducted by a patient into an imaging region of the MR imaging system. The sensor may comprise at least one electrical conductor configured for electrically coupling to the patient. The MR imaging system may further comprise a noise reduction system configured to receive the electromagnetic interference from the sensor and to suppress electromagnetic interference in detected MR signals received by the MR imaging system based on the electromagnetic interference detected by the sensor.

Abstract: Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.

Abstract: Example embodiments are directed to systems and methods for providing end of route navigation. A network system identifies a destination of a route and retrieves a display template based on the destination. The display template provides guidelines for display of end of route content, whereby the display of the end of the route content is different than display of content during a middle of the route. Based on the display template, a display time to trigger display of the end of the route content. The display time may be associated with a threshold distance to the destination. The network system monitors a location of a vehicle along the route and accesses end of route content. Responsive to detecting that the location of the vehicle is at the threshold distance to the destination, the end of the route content is displayed on a device associated with the vehicle.

Abstract: A method for forming glass ceramic articles includes heating a stack of glass sheets to a nucleation temperature to create a nucleated crystallizable stack of sheets; heating the nucleated crystallizable stack of glass sheets to a crystallization temperature; and maintaining the crystallization temperature for a predetermined period of time to produce the glass-ceramic articles. The stack of glass sheets has a mass index of less than or equal to 35.

Abstract: Disclosed are various embodiments for sales lead generation utilizing a photo of a unique identifier or identifiers of a vehicle at a store. In another aspect a method for generating a sales lead from a photo of a vehicle with a unique identifier is disclosed. The method first provisions a relational database with a dataset of unique vehicle identifiers. Next, is provisioning the field device with a sales/lead application. Then executing the sales/lead application on non-transitory memory of the field device. Then capturing a photo of a vehicle with a unique identifier. Next, transmitting photo to a central system. Then processing the photo for optical character recognition with an image analysis module. The method then generates the unique vehicle identifier from the photo. Next, it accesses the relational database to perform a lookup of the unique vehicle identifier. Lastly, it generates a sales lead based on at least the unique vehicle identifier.

Abstract: Method of treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof, the method involving administering to the subject a therapeutically effective amount of secnidazole or a pharmaceutically acceptable salt in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules. The subject can also have bacterial vaginosis, is HIV-positive, and/or is suffering with metronidazole-resistant trichomoniasis and/or tinidazole-resistant trichomoniasis. The subject can also be a sexual partner of a person with trichomoniasis. The microgranule formulation can also be administered with paromomycin, tinidazole, metronidazole, boric acid or a combination thereof. Pharmaceutical compositions and uses for treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof are also contemplated herein.