Patents by Inventor Carolyn Bertozzi

Carolyn Bertozzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200317778
    Abstract: Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells.
    Type: Application
    Filed: December 21, 2018
    Publication date: October 8, 2020
    Inventors: Anton Wyss-Coray, John Vincent Pluvinage, Michael C. Bassik, Michael Haney, Benjamin Smith, Carolyn Bertozzi
  • Publication number: 20200309784
    Abstract: Methods and reagents for multiplex detection of antibodies are disclosed. In particular, the invention relates to multiplex detection of antibodies using antigen-DNA and antibody-binding agent-DNA conjugates carrying DNA barcodes for identifying and quantitating disease-relevant antibody isotypes, such as those involved in allergic responses, autoimmune diseases, infections, and inflammation.
    Type: Application
    Filed: March 29, 2018
    Publication date: October 1, 2020
    Inventors: Carolyn Bertozzi, Stephen J. Galli, Kaori Mukal, Peter Robinson, Cheng-ting Tsai, Mindy Tsai
  • Patent number: 9969970
    Abstract: The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: May 15, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Shih-Chia Hsiao, Matthew B. Francis, Carolyn Bertozzi, Richard Mathies, Ravi Chandra, Erik Douglas, Amy Twite, Nicholas Toriello, Hiroaki Onoe
  • Publication number: 20180100181
    Abstract: Methods are provided for detecting antigen binding agents in samples. Aspects of the methods include detection of the aggregation of antigen binding agents with polynucleotide-bound antigens by sensitive proximity-based association of the antigen-bound polynucleotides. Aspects of the methods also include methods for the detection of such proximity-based association through nucleic acid amplification. In addition, compositions, e.g., reagents, kits, and devices, useful in practicing various embodiments of the methods are provided.
    Type: Application
    Filed: April 15, 2016
    Publication date: April 12, 2018
    Inventors: Peter Robinson, Cheng-Ting Tsai, Carolyn Bertozzi
  • Patent number: 9605078
    Abstract: Aldehyde- and ketone-functionalized proteins are promising new substrates for the development of chemically modified biotherapeutics and protein-based materials. Their reactive carbonyl groups are typically conjugated with a-effect nucleophiles, such as substituted hydrazines and alkoxyamines, to generate hydrazones and oximes, respectively. However, the resulting C?N linkages are susceptible to hydrolysis under physiologically relevant conditions, which limits their utility in biological systems. Here we introduce a Pictet-Spengler ligation that is based on the classic Pictet-Spengler reaction of aldehydes and tryptamine nucleophiles. The ligation exploits the bioorthogonal reaction of aldehydes and alkoxyamines to form an intermediate oxyiminium ion; this intermediate undergoes intramolecular C—C bond formation with an indole nucleophile to form an oxacarboline product that is hydrolytically stable.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: March 28, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Carolyn Bertozzi, Paresh Agarwal, Ellen M. Sletten
  • Publication number: 20160319238
    Abstract: The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.
    Type: Application
    Filed: March 1, 2016
    Publication date: November 3, 2016
    Inventors: Shih-Chia Hsiao, Matthew B. Francis, Carolyn Bertozzi, Richard Mathies, Ravi Chandra, Erik Douglas, Amy Twite, Nicholas Toriello, Hiroaki Onoe
  • Patent number: 9447390
    Abstract: The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: September 20, 2016
    Assignee: The Regents of the University of California
    Inventors: Isaac S. Carrico, Brian L. Carlson, Peng Wu, Carolyn Bertozzi
  • Patent number: 9327036
    Abstract: The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: May 3, 2016
    Assignee: The Regents of the University of California
    Inventors: Shih-Chia Hsiao, Matthew B. Francis, Carolyn Bertozzi, Richard Mathies, Ravi Chandra, Erik Douglas, Amy Twite, Nicholas Toriello, Hiroaki Onoe
  • Patent number: 9162939
    Abstract: The present invention provides cycloparaphenylene compounds, their macrocyclic precursors, and methods for making the compounds. The cycloparaphenylene compounds can be used to prepare armchair carbon nanotubes.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: October 20, 2015
    Assignee: The Regents of The University of California
    Inventors: Ramesh Jasti, Carolyn Bertozzi
  • Publication number: 20150291699
    Abstract: Aldehyde- and ketone-functionalized proteins are promising new substrates for the development of chemically modified biotherapeutics and protein-based materials. Their reactive carbonyl groups are typically conjugated with a-effect nucleophiles, such as substituted hydrazines and alkoxyamines, to generate hydrazones and oximes, respectively. However, the resulting C?N linkages are susceptible to hydrolysis under physiologically relevant conditions, which limits their utility in biological systems. Here we introduce a Pictet-Spengler ligation that is based on the classic Pictet-Spengler reaction of aldehydes and tryptamine nucleophiles. The ligation exploits the bioorthogonal reaction of aldehydes and alkoxyamines to form an intermediate oxyiminium ion; this intermediate undergoes intramolecular C—C bond formation with an indole nucleophile to form an oxacarboline product that is hydrolytically stable.
    Type: Application
    Filed: November 15, 2013
    Publication date: October 15, 2015
    Inventors: Carolyn Bertozzi, Paresh Agarwal, Ellen M. Sletten
  • Publication number: 20150152022
    Abstract: The present invention provides cycloparaphenylene compounds, their macrocyclic precursors, and methods for making the compounds. The cycloparaphenylene compounds can be used to prepare armchair carbon nanotubes.
    Type: Application
    Filed: February 12, 2015
    Publication date: June 4, 2015
    Inventors: Ramesh Jasti, Carolyn Bertozzi
  • Patent number: 8987538
    Abstract: The present invention provides cycloparaphenylene compounds, their macrocyclic precursors, and methods for making the compounds. The cycloparaphenylene compounds can be used to prepare armchair carbon nanotubes.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: March 24, 2015
    Assignee: The Regents of the University of California
    Inventors: Ramesh Jasti, Carolyn Bertozzi
  • Publication number: 20150072398
    Abstract: The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
    Type: Application
    Filed: August 20, 2014
    Publication date: March 12, 2015
    Inventors: Isaac S. Carrico, Brian L. Carlson, Peng Wu, Carolyn Bertozzi
  • Patent number: 8846866
    Abstract: The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: September 30, 2014
    Assignee: The Regents of the University of California
    Inventors: Isaac S. Carrico, Brian L. Carlson, Peng Wu, Carolyn Bertozzi
  • Patent number: 8729232
    Abstract: The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: May 20, 2014
    Assignee: The Regents of The University of California
    Inventors: Jason S. Rush, Carolyn Bertozzi
  • Publication number: 20130245327
    Abstract: The present invention provides cycloparaphenylene compounds, their macrocyclic precursors, and methods for making the compounds. The cycloparaphenylene compounds can be used to prepare armchair carbon nanotubes.
    Type: Application
    Filed: May 6, 2013
    Publication date: September 19, 2013
    Applicant: The Regents of the University of California
    Inventors: Ramesh Jasti, Carolyn Bertozzi
  • Patent number: 8461403
    Abstract: The present invention provides cycloparaphenylene compounds, their macrocyclic precursors, and methods for making the compounds. The cycloparaphenylene compounds can be used to prepare armchair carbon nanotubes.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: June 11, 2013
    Assignee: The Regents of the University of California
    Inventors: Ramesh Jasti, Carolyn Bertozzi
  • Publication number: 20120302514
    Abstract: Disclosed are compositions containing glycoconjugates and methods for making the functionalized glycoconjugates, which include (a) contacting a cell with a first monosaccharide, and (b) incubating the cell under conditions whereby the cell (i) internalizes the first monosaccharide, (ii) biochemically processes the first monosaccharide into a second saccharide, (iii) conjugates the saccharide to a carrier to form a glycoconjugate, and (iv) extracellularly expresses the glycoconjugate to form an extracellular glycoconjugate comprising a selectively reactive functional group. Methods for forming products at a cell further comprise contacting the functional group of the extracellularly expressed glycoconjugate with an agent that selectively reacts with the functional group to form a product. Subject compositions include cyto-compatible monosaccharides comprising a nitrogen or ether linked functional group selectively reactive at a cell surface and compositions and cells comprising such saccharides.
    Type: Application
    Filed: October 30, 2007
    Publication date: November 29, 2012
    Inventors: Carolyn Bertozzi, Kevin J. Yarema, Lara K. Mahal
  • Publication number: 20120142088
    Abstract: The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.
    Type: Application
    Filed: April 8, 2010
    Publication date: June 7, 2012
    Applicant: The Regents of the University of California
    Inventors: Shih-Chia Hsiao, Matthew B. Francis, Carolyn Bertozzi, Richard Mathies, Ravi Chandra, Erik Douglas, Amy Twite, Nicholas Toriello, Hiroaki Onoe
  • Publication number: 20110287041
    Abstract: The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
    Type: Application
    Filed: June 17, 2011
    Publication date: November 24, 2011
    Inventors: Isaac S. Carrico, Brian L. Carlson, Peng Wu, Carolyn Bertozzi