Patents by Inventor Caryn Bowe

Caryn Bowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Erythropoietin: remodeling and glycoconjugation of erythropoietin
    Publication number: 20080187955
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: February 2, 2007
    Publication date: August 7, 2008
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, Caryn Bowe, David James Hakes, Xi Chen
  • Sialic acid nucleotide sugars
    Patent number: 7399613
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: July 15, 2008
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Glycoconjugation methods and proteins/peptides produced by the methods
    Publication number: 20080146494
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: March 5, 2007
    Publication date: June 19, 2008
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, Caryn Bowe, David James Hakes, Xi Chen
  • Factor VIII: Remodeling and glycoconjugation of factor VIII
    Publication number: 20080070275
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: December 26, 2006
    Publication date: March 20, 2008
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
    Publication number: 20080050772
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: January 11, 2007
    Publication date: February 28, 2008
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Glycopegylated Follicle Stimulating Hormone
    Publication number: 20080015142
    Abstract: The present invention provides conjugates between follicle stimulating hormone and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
    Type: Application
    Filed: December 3, 2004
    Publication date: January 17, 2008
    Inventors: Shawn DeFrees, Robert J. Bayer, Caryn Bowe
  • Interferon alpha: remodeling and glycoconjugation of interferon alpha
    Patent number: 7297511
    Abstract: The invention includes a multitude of methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: November 20, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Glycopegylated Granulocyte Colony Stimulating Factor
    Publication number: 20070254836
    Abstract: The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
    Type: Application
    Filed: December 3, 2004
    Publication date: November 1, 2007
    Inventors: Shawn Defrees, Henrik Clausen, David Zopf, Zhi-Guang Wang, Caryn Bowe, Marc Schwartz, Bingyuan Wu
  • Remodeling and glycoconjugation of peptides
    Patent number: 7276475
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: October 2, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David A. Zopf, Caryn Bowe
  • Glycopegylation methods and proteins/peptides produced by the methods
    Patent number: 7265084
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: September 4, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, Caryn Bowe, David James Hakes, Xi Chen
  • Glycoconjugation methods and proteins/peptides produced by the methods
    Patent number: 7265085
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: September 4, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Interferon beta: remodeling and glycoconjugation of interferon beta
    Patent number: 7226903
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: June 5, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Erythropoietin: remodeling and glycoconjugation of erythropoietin
    Patent number: 7214660
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: May 8, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, Caryn Bowe, David James Hakes, Xi Chen
  • ERYTHROPOIETIN: REMODELING AND GLYCOCONJUGATION OF ERYTHROPOIETIN
    Publication number: 20070042458
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2003
    Publication date: February 22, 2007
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Factor IX: remolding and glycoconjugation of Factor IX
    Patent number: 7179617
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: February 20, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David James Hakes, Xi Chen
  • Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
    Patent number: 7173003
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: February 6, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Erythropoietin: remodeling and glycoconjugation of erythropoietin
    Publication number: 20070027068
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: October 8, 2003
    Publication date: February 1, 2007
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, David Hakes, Caryn Bowe, Xi Chen
  • Glycopegylation methods and proteins/peptides produced by the methods
    Publication number: 20070026485
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2004
    Publication date: February 1, 2007
    Applicant: NEOSE TECHNOLOGIES, INC.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, David Hakes, Caryn Bowe, Xi Chen
  • Glycopegylated granulocyte colony stimulating factor
    Publication number: 20070014759
    Abstract: The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
    Type: Application
    Filed: November 2, 2005
    Publication date: January 18, 2007
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, Henrik Clausen, David Zopf, Zhi-Guang Wang, Caryn Bowe
  • Factor VIII remodeling and glycoconjugation of Factor VIII
    Patent number: 7157277
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: January 2, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen