Patents by Inventor Catherine M. Verfaillie

Catherine M. Verfaillie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stem Cell Aggregates and Methods for Making and Using
    Publication number: 20220213435
    Abstract: The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells.
    Type: Application
    Filed: January 13, 2022
    Publication date: July 7, 2022
    Applicants: Regents of the University of Minnesota, Katholieke Universiteit Leuven
    Inventors: Wei-Shou Hu, Kartik Subramanian, Catherine M. Verfaillie
  • Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
    Patent number: 10638734
    Abstract: The present invention relates generally to mammalian multipotent adult stem cells (MASC), and more specifically to methods for obtaining, maintaining and differentiating MASC to cells of multiple tissue types. Uses of MASC in the therapeutic treatment of disease are also provided.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: May 5, 2020
    Assignees: ABT Holding Company, Regents of the University of Minnesota
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • Homologous recombination in multipotent adult progenitor cells
    Patent number: 10583202
    Abstract: The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: March 10, 2020
    Assignees: ABT Holding Company, Regents of the University of Minnesota
    Inventors: Catherine M. Verfaillie, Uma Lakshmipathy
  • Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells
    Patent number: 10457914
    Abstract: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express hepatocyte phenotypes and hepatocyte progenitor phenotypes. More particularly, the invention relates to methods for culturing cells so that the cells are induced to differentiate into cells that express a definitive endodermal phenotype, a liver-committed endodermal phenotype, a hepatoblast phenotype, and hepatocyte phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: October 29, 2019
    Assignee: Katholieke Universiteit Leuven
    Inventors: Karen Pauwelyn, Catherine M. Verfaillie
  • Stem Cell Aggregates and Methods for Making and Using
    Publication number: 20190233794
    Abstract: The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, undo dermal, and mesodermal embryonic germ layers, e.g., stem cells.
    Type: Application
    Filed: January 28, 2019
    Publication date: August 1, 2019
    Applicants: Regents of the University of Minnesota, Katholieke Universiteit Leuven
    Inventors: Wei-Shou Hu, Kartik Subramanian, Catherine M. Verfaillie
  • Stem cell aggregates and methods for making and using
    Patent number: 10253297
    Abstract: The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, undo dermal, and mesodermal embryonic germ layers, e.g., stem cells.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: April 9, 2019
    Assignees: Regents of the University of Minnesota, Katholieke Universiteit Leuven
    Inventors: Wei-Shou Hu, Kartik Subramanian, Catherine M. Verfaillie
  • Multipotent adult stem cells and methods for isolation
    Patent number: 10226485
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Grant
    Filed: March 21, 2005
    Date of Patent: March 12, 2019
    Assignees: ABT Holding Company, Regents of the University of Minnesota
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • HOMOLOGOUS RECOMBINATION IN MULTIPOTENT ADULT PROGENITOR CELLS
    Publication number: 20180272000
    Abstract: The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided.
    Type: Application
    Filed: September 19, 2017
    Publication date: September 27, 2018
    Applicants: ABT Holding Company, Regents of the University of Minnesota
    Inventors: Catherine M. Verfaillie, Uma Lakshmipathy
  • Multipotent adult stem cells and methods for isolation
    Patent number: 10006004
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: June 26, 2018
    Assignee: ABT Holding Company
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • Multipotent adult stem cells and methods for isolation
    Patent number: 9974810
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: May 22, 2018
    Assignee: ABT Holding Company
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • Multipotent adult stem cells and methods for isolation
    Patent number: 9974811
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: May 22, 2018
    Assignee: ABT Holding Company
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • Multipotent adult stem cells and methods for isolation
    Patent number: 9974809
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: May 22, 2018
    Assignee: ABT Holding Company
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • Multipotent Adult Stem Cells and Methods for Isolation
    Publication number: 20180110806
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Application
    Filed: October 13, 2017
    Publication date: April 26, 2018
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • Multipotent adult stem cells and methods for isolation
    Patent number: 9789136
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: October 17, 2017
    Assignees: ABT Holding Company, Regents of the University of Minnesote
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the method, and methods for using the cells
    Patent number: 9777258
    Abstract: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype and cells that express a hepatic sinusoidal endothelial phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: October 3, 2017
    Assignee: Katholieke Universiteit Leuven
    Inventors: Pau Sancho-Bru, Catherine M. Verfaillie
  • Compositions and methods for the treatment of lysosomal storage disorders
    Patent number: 9700601
    Abstract: The present invention relates to methods for providing lysosomal enzymes to a subject by administering stem cells, preferably Multipotent Adult Progenitor Cells (MAPCs). The invention further relates to methods for treating lysosomal storage disorders by administering stem cells.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: July 11, 2017
    Assignee: Regents of The University of Minnesota
    Inventors: Bruce Blazer, Jakub Tolar, Catherine M. Verfaillie
  • Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure
    Patent number: 9526747
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells in cardiac indications.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: December 27, 2016
    Assignee: Regents of the University of Minnesota
    Inventors: Catherine M. Verfaillie, Morayma Reyes, Leo T. Furcht
  • Non-static suspension culture of cell aggregates
    Patent number: 9447380
    Abstract: The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: September 20, 2016
    Assignees: Regents of The University of Minnesota, Katholieke Universiteit Leuven
    Inventors: Kartik Subramanian, Wei-Shou Hu, Catherine M. Verfaillie, Yonsil Park
  • Methods for making cells with an extra-embryonic endodermal precursor phenotype
    Patent number: 9388388
    Abstract: The invention is directed to methods for making cells in vitro that have an extra-embryonic endodermal precursor phenotype. The method involves culturing cells from blastocysts under specific defined conditions.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: July 12, 2016
    Assignees: Katholieke Universiteit Leuven, Hanyang University of Korea
    Inventors: Catherine M. Verfaillie, Bert Binas
  • METHODS FOR DIFFERENTIATING CELLS INTO HEPATIC STELLATE CELLS AND HEPATIC SINUSOIDAL ENDOTHELIAL CELLS, CELLS PRODUCED BY THE METHOD, AND METHODS FOR USING THE CELLS
    Publication number: 20160145570
    Abstract: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype and cells that express a hepatic sinusoidal endothelial phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.
    Type: Application
    Filed: June 25, 2015
    Publication date: May 26, 2016
    Applicant: Katholieke Universiteit Leuven
    Inventors: Pau Sancho-Bru, Catherine M. Verfaillie