Patents by Inventor Catherine M. Verfaillie

Catherine M. Verfaillie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multipotent Adult Stem Cells, Sources Thereof, Methods of Obtaining and Maintaining Same, Methods of Differentiation Thereof, Methods of Use Thereof and Cells Derived Thereof
    Publication number: 20110171659
    Abstract: The present invention relates generally to mammalian multipotent adult stem cells (MASC), and more specifically to methods for obtaining, maintaining and differentiating MASC to cells of multiple tissue types. Uses of MASC in the therapeutic treatment of disease are also provided.
    Type: Application
    Filed: October 19, 2010
    Publication date: July 14, 2011
    Applicants: ABT HOLDING COMPANY, REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: LEO T. FURCHT, CATHERINE M. VERFAILLIE, MORAYMA REYES
  • Stem Cell Aggregates and Methods for Making and Using
    Publication number: 20110111492
    Abstract: The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stern cells but can differentiate into cell types of at least two of ectodermal, undo dermal, and mesodermal embryonic germ layers, e.g., stem cells.
    Type: Application
    Filed: January 21, 2009
    Publication date: May 12, 2011
    Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA, KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Wei-Shou Hu, Kartik Subramanian, Catherine M. Verfaillie
  • MAPC administration for the treatment of lysosomal storage disorders
    Patent number: 7927587
    Abstract: The present invention relates to methods for providing lysosomal enzymes to a subject by administering stem cells, preferably Multipotent Adult Progenitor Cells (MAPCs). The invention further relates to methods for treating lysosomal storage disorders by administering stem cells.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: April 19, 2011
    Assignee: Regents of the University of Minnesota
    Inventors: Bruce Blazer, Jakub Tolar, Catherine M. Verfaillie
  • Swine multipotent adult progenitor cells
    Patent number: 7883892
    Abstract: The present invention provides swine cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple cell types. Also provided are methods of isolation and culture, as well as uses for the cells, such as xenogeneic transplantation and/or tissue repair.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: February 8, 2011
    Assignee: Regents of the University of Minnesota
    Inventors: Catherine M. Verfaillie, Lepeng Zeng, Jianyi Zhang
  • Assay utilizing multipotent adult stem cells
    Patent number: 7838289
    Abstract: The present invention relates generally to mammalian multipotent adult stem cells (MASC), and more specifically to methods for obtaining, maintaining and differentiating MASC to cells of multiple tissue types. Uses of MASC in the therapeutic treatment of disease are also provided.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: November 23, 2010
    Assignees: ABT Holding Company, Regents of the University of Minnesota
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • Multipotent adult stem cells
    Patent number: 7659118
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Grant
    Filed: September 29, 2005
    Date of Patent: February 9, 2010
    Assignees: ABT Holding Company, Regents of the University of Minnesote
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • MULTIPOTENT ADULT STEM CELLS AND METHODS FOR ISOLATION
    Publication number: 20090233353
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Application
    Filed: April 1, 2009
    Publication date: September 17, 2009
    Applicants: The Regents of the University of Minnesota, ABT Holding Company
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • MULTIPOTENT ADULT STEM CELLS AND METHODS FOR ISOLATION
    Publication number: 20090233354
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Application
    Filed: April 1, 2009
    Publication date: September 17, 2009
    Applicants: The Regents of the University of Minnesota, ABT Holding Company
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • MULTIPOTENT ADULT STEM CELLS AND METHODS FOR ISOLATION
    Publication number: 20090203130
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Application
    Filed: April 1, 2009
    Publication date: August 13, 2009
    Applicants: The Regents of the University of Minnesota, ABT Holding Company
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • MULTIPOTENT ADULT STEM CELLS AND METHODS FOR ISOLATION
    Publication number: 20090203129
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Application
    Filed: April 1, 2009
    Publication date: August 13, 2009
    Applicants: The Regemts of the university of Minnesota, ABT Holding Company
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • Vascular/Lymphatic Endothelial Cells
    Publication number: 20090104159
    Abstract: The present invention provides methods to culture and use vascular endothelial cells, including lymphatic, venous and arterial endothelial cells.
    Type: Application
    Filed: February 10, 2006
    Publication date: April 23, 2009
    Inventors: Felipe Prosper, Catherine M. Verfaillie, Xabier Lopez-Aranguren, Carlos Clavel Claver, Aernout Luttun
  • DIFFERENTIATION OF NON-EMBRYONIC STEM CELLS TO CELLS HAVING A PANCREATIC PHENOTYPE
    Publication number: 20090092586
    Abstract: The invention provides methods for differentiating non-embryonic multipotent stem cells along the pancreatic lineage. The present invention further provides non-embryonic multipotent stem cells and progeny derived therefrom to provide pancreatic cells to a subject.
    Type: Application
    Filed: October 16, 2006
    Publication date: April 9, 2009
    Inventors: Catherine M. Verfaillie, Miguel Angel Barajas Velez, Yves Pierre Heremans
  • Use of Nk Cell Inhibition to Facilitate Persistence of Engrafted Mhc-I-Negative Cells
    Publication number: 20080317740
    Abstract: The present invention relates to the use of a means for inhibiting NK cell function to increase persistence and/or engraftment of MHC-I negative cells, such as MAPCs.
    Type: Application
    Filed: May 5, 2005
    Publication date: December 25, 2008
    Inventors: Bruce Blazar, Jakub Tolar, Catherine M. Verfaillie
  • Mapc Engraftment in the Hematopoietic System
    Publication number: 20080311084
    Abstract: The present invention relates to MAPCs and progeny derived therefrom to provide lymphohematopoietic cells in a tissue of the lymphohematopoietic system of a subject.
    Type: Application
    Filed: July 29, 2005
    Publication date: December 18, 2008
    Inventors: Catherine M. Verfaillie, Uma Lakshmipathy, Marta Serafini, Shannon Buckley
  • Multiponent adult stem cells and methods for isolation
    Patent number: 7015037
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: March 21, 2006
    Assignees: Regents of the University of Minnesota, MCL/LLC
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • Multipotent adult stem cells, sources thereof, methods of obtaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
    Publication number: 20040107453
    Abstract: The present invention relates generally to mammalian multipotent adult stem cells (MASC), and more specifically to methods for obtaining, maintaining and differentiating MASC to cells of multiple tissue types. Uses of MASC in the therapeutic treatment of disease are also provided.
    Type: Application
    Filed: January 5, 2004
    Publication date: June 3, 2004
    Inventors: Leo T Furcht, catherine M Verfaillie, Morayma Reyes
  • METHOD TO PREPARE DRUG-RESISTANT, NON-MALIGNANT HEMATOPOIETIC CELLS
    Publication number: 20020081733
    Abstract: A method to prepare drug-resistant, non-malignant hematopoietic cells is provided.
    Type: Application
    Filed: May 14, 1998
    Publication date: June 27, 2002
    Inventors: CATHERINE M. VERFAILLIE, R. SCOTT MCIVOR, ROBERT C. ZHAO
  • Ex vivo culture of stem cells
    Patent number: 5922597
    Abstract: A method for the culture of hematopoietic cells is provided comprising culturing said cells in stromal conditioned medium comprising one or more cytokines selected from the group consisting of MIP-1.alpha., IL-3, SCF, BB10010 and PF-4, so that the ability of the stem cells to self-replicate and differentiate is maintained or the ability of the committed progenitors to expand and differentiate is maintained.
    Type: Grant
    Filed: July 14, 1997
    Date of Patent: July 13, 1999
    Assignee: Regents of the University of Minnesota
    Inventors: Catherine M. Verfaillie, Philip B. McGlave, Jeffrey S. Miller
  • Stroma-derived stem cell proteoglycan growth factor
    Patent number: 5605829
    Abstract: An anionic macromolecular containing composition is disclosed that is capable of supporting conservation and differentiation of long-term bone marrow culture initiating cells in cultured mammalian hematopoietic cells. The composition disclosed is a mixture of glycoproteins, more specifically proteoglycans, which are of a molecular weight greater than 200 kD.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: February 25, 1997
    Assignee: Regents of the University of Minnesota
    Inventors: Philip B. McGlave, Catherine M. Verfaillie, Pankaj Gupta
  • Stroma-derived proteoglycan containing composition which promotes differentiation and maintains the self-renewal capacity of long-term bone marrow culture-initiating cells
    Patent number: 5523286
    Abstract: An anionic macromolecular containing composition is disclosed that is capable of supporting conservation and differentiation of long-term bone marrow culture initiating cells in cultured mammalian hematopoietic cells. The composition disclosed is a mixture of glycoproteins, more specifically proteoglycans, which are of a molecular weight greater than 200 kD.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: June 4, 1996
    Assignee: Regents of the University of Minnesota
    Inventors: Philip B. McGlave, Catherine M. Verfaillie