Patents by Inventor Catherine McIntyre

Catherine McIntyre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for in vitro expansion and transdifferentiation of human pancreatic acinar cells into insulin-producing cells
    Publication number: 20060275900
    Abstract: This invention relates, e.g., to a method for expanding mammalian acinar cells, comprising culturing the cells in a cell culture system comprising a cell culture medium and a cell attachment surface, under conditions wherein the acinar cells undergo a 3-4 fold expansion together with transdifferentiation into a modified cell phenotype (IP cells) showing characteristics of acinar cells and liver cells. The invention also relates to a method for transforming these IP cells to insulin-producing cells in vitro, comprising culturing the cells in a novel, defined medium. Also disclosed are suitable culture media for performing these methods, isolated cells having the phenotype of IP cells and/or produced by these methods, and kits for performing the methods.
    Type: Application
    Filed: April 26, 2006
    Publication date: December 7, 2006
    Applicants: Becton, Dickinson and Company, Novocell, Inc.
    Inventors: Sharon Presnell, Mohammad Heidaran, Perry Haaland, David Scharp, Paul Latta, Margaret Coutts, Catherine McIntyre
  • Methods for in vitro expansion and transdifferentiation of human pancreatic acinar cells into insulin-producing cells
    Publication number: 20060122104
    Abstract: This invention relates, e.g., to a method for expanding mammalian acinar cells, comprising culturing the cells in a cell culture system comprising a cell culture medium and a cell attachment surface, under conditions wherein the acinar cells undergo a 3-4 fold expansion together with transdifferentiation into a modified cell phenotype (IP cells) showing characteristics of acinar cells and liver cells. The invention also relates to a method for transforming these IP cells to insulin-producing cells in vitro, comprising culturing the cells in a novel, defined medium. Also disclosed are suitable culture media for performing these methods, isolated cells having the phenotype of IP cells and/or produced by these methods, and kits for performing the methods.
    Type: Application
    Filed: May 22, 2003
    Publication date: June 8, 2006
    Inventors: Sharon Presnell, Mohammad Heidaran, Perry Haaland, Neil Robbins, David Scharp, Paul Latta, Margaret Coutts, Catherine McIntyre