Abstract: The present invention relates to methods for identifying Richter's transformation patients who benefit from PD-1 blockade.

Abstract: A mass reducing projectile is provided. The mass reducing projectile includes a shell, one or more weights, and a low melt fusible alloy. The one or more weights are disposed within the shell. The low melt fusible alloy is disposed within the shell so as to encase the one or more weights within the shell.

Abstract: Systems, devices, methods, and computer readable medium for evaluating visual quality of digital content are disclosed. Methods can include training machine learning models on images. A request is received to evaluate quality of an image included in a current version of a digital component generated by the computing device. The machine learning models are deployed on the image to generate a score for each quality characteristic of the image. A weight is assigned to each score to generate weighted scores. The weighted scores are combined to generate a combined score for the image. The combined score is compared to one or more thresholds to generate a quality of the image.

Abstract: This invention relates generally to methods of dosing pharmaceutical compositions and preparations of circular polyribonucleotides thereof.

Abstract: A process for making a poly alpha-olefin (PAO) having high vinylidene content (or combined vinylidene and tri-substituted vinylene content) and low vinyl and/or di-substituted vinylene content, as well as a relatively low molecular weight comprising contacting a feed containing a C6-C32 alpha-olefin with a catalyst system comprising non-aromatic-hydrocarbon soluble activator and a metallocene compound, typically a cyclopentadienyl-tetrahydro-s-indacenyl group 4 transition metal compound.

Abstract: A dynamic aperture is disclosed. A dynamic aperture includes a base layer, a conductive structure disposed on the base layer, and a layer of a material having a dynamically controllable electrical conductivity that is disposed over the base layer and the conductive structure. A transmission profile of the dynamic aperture is determined by a combination of the conductive structure and the layer of the material. The transmission profile is dynamically alterable by controlling the electrical conductivity of the layer of the material.

Abstract: A respiratory mask for continuous positive airway pressure treatment includes a cushion adapted to be positioned against the face of a patient. The cushion is configured in a gasket arrangement around an entrance to the airways of the patient. The cushion is constructed from a polyurethane foam and has a thickness of greater than about 5 mm.

Abstract: An article that includes a functionalized copolymer and the use thereof, particularly in a process for binding biomaterials, such as in a process for separating aggregated proteins from monomeric proteins in a biological solution; wherein the article includes: a) a porous substrate; and b) a copolymer covalently attached to the porous substrate, the copolymer comprising a hydrocarbon backbone and a plurality of pendant groups attached to the hydrocarbon backbone, wherein 1) each of a first plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and 2) each of a second plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and wherein the

Abstract: A computer-assisted surgery system for obtaining a distance between at least two fixed points relative to a bone comprises a first accelerometer unit located at a first fixed location on the bone, and producing first acceleration data during a movement of the bone. A second accelerometer unit is located at a second fixed location on the bone, and simultaneously producing second acceleration data during the movement. A gyroscope unit is fixed to the bone and simultaneously producing angular rates of change of said movement. A processor unit obtains the acceleration data and the angular rates of change for calculating the distance between the first fixed position and the second fixed position on the bone using a distance value of a distance vector between the accelerometer units. An interface outputs the distance between the first fixed position and the second fixed position relative to the bone. A method for calculating a distance between at least two points on a bone is provided.

Abstract: Non-viral nucleic acid delivery agents and methods for the delivery or transfer of nucleic acid molecules to target cells are disclosed. The agents comprise a complex of a nucleic acid cargo for delivery, one or more lipopeptide compound, and one or more polymeric charge-neutralising agent, and the complex is in the form of a particle with substantially neutral or negative surface charge. The agents and methods may be useful in a variety of applications such as therapies (including gene therapies and nucleic acid vaccinations) for diseases and medical disorders.

Abstract: A computer server system comprises a communications module; a processor coupled with the communications module; and a memory coupled to the processor and storing processor-executable instructions which, when executed by the processor, configure the processor to receive, via the communications module and from a first device, a signal including a request to schedule access to a shared resource within a time window; identify, based on a load projection for the shared resource, at least one time period within the time window for the access to the shared resource; send, via the communications module and to the first device, a signal including the at least one time period and requesting confirmation that a particular one of the at least one time period is acceptable; receive, via the communications module and from the first device, a signal including confirmation that the particular one of the at least one time period is acceptable; determine that a current time has reached the particular one of the at least one ti

Abstract: Embodiments provided herein include methods, compositions, and uses of aromatic alcohols to increase the potency of antifungal agents.

Abstract: Polymeric coating compositions and articles coated with the polymeric coating compositions are provided. The polymeric coating composition can include an ethylene-based polymer that exhibits desirable melting properties and molecular weight distribution. The polymeric coating composition can provide a thin coating layer on an article while still providing advantageous properties, such as seal strength.

Abstract: Systems and methods for determining an optimal delivery location based on delivery address and delivery time are provided. An example method includes receiving an online order from a user application installed on a user device; generating a map comprising a dynamic display of a local service area polygon associated with the online order and transmitting the map to the user application; transmitting to the user application a request for a delivery address; upon receipt of the delivery address, querying the delivery address to determine whether the local service area polygon includes the delivery address; transmitting to the user application a request for a delivery time; upon receipt of the delivery time, automatically recommending an optimal delivery location and time within the local service area polygon based on the delivery address and delivery time; and executing a delivery of the online order based on the optimal delivery location and time.

Abstract: A contact lens treating solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the contact lens treating solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the contact lens treating solution, of erythritol; (c) one or more nonionic surfactants; (d) sodium chloride, potassium chloride or any combination thereof; and (e) one or more buffers.

Abstract: Amide compounds of formula (I): and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of Kinesin Motor Protein KIF18A, such as cancer, psoriasis, atopic dermatitis, an autoimmune disorder, or inflammatory bowel disease, and the like.

Abstract: A portable wind turbine, consisting primarily of a nacelle with collapsible blades for transportation is provided. Each of these collapsible rotor blades has been designed with an impellor, or propeller, twist. This is typical of wind turbine blades in order to maximize torque and reduce drag during operation, with the exception that said blades also conform to the nacelle's surface, which is one of a solid of revolution shapes, for transportation of the turbine. The described portable wind turbine assembly is accompanied with collapsible mounting apparatus, for internal or external storage to the turbine's nacelle, wholly or partially stored control electronics within the nacelle, as well as an optional energy storage component that is located internally or externally to the turbine's body. This turbine invention can be person-portable, deployed on vehicles, trailers, marine vessels and structures, above water, or used for locations where storm-strength winds are a risk.

Abstract: A preservative-free contact lens treating solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the preservative-free contact lens treating solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the preservative-free contact lens treating solution, of erythritol; (c) one or more nonionic surfactants; (d) sodium chloride, potassium chloride or any combination thereof; and (e) one or more buffers.

Abstract: A method of manufacturing an electronic circuit comprising a first device and at least a second device is disclosed. The first device comprises a first terminal, a second terminal, and a first body of semiconductive material providing a semiconductive path between the first and second terminals, and the second device comprises a third terminal, a fourth terminal, and a second body of material providing a resistive or semiconductive current path between the third terminal and the fourth terminal. The method comprises: forming the first body; and forming the second body, wherein the first body comprises a first quantity of a metal oxide and the second body comprises a second quantity of said metal oxide. Corresponding electronic circuits are disclosed.

Abstract: The present invention relates to a humidification apparatus having a compartment that receives a removable humidification chamber. The apparatus has an actuator that can be operated by a user to move the humidification chamber from an operating position to a releasing position. In the operating position the humidification chamber is received by the humidification compartment and forms a portion of the flow path through the humidification apparatus. In the releasing position the humidification chamber is displaced outwardly from the operating position so that a user can more easily remove the humidification chamber from the apparatus.