Abstract: Various implementations include a wheelchair traction attachment device. The device includes a frame having an arcuately-shaped longitudinal axis, an inner surface, an outer surface opposite and spaced apart from the inner surface. The frame has a first edge extending between the inner and outer surfaces, and a second edge spaced apart from the first edge. At least a portion of the inner surface defines a channel. The device includes at least one first wheel-clip extending radially inwardly from the first edge of the frame relative to the arcuately-shaped longitudinal axis. The device includes at least one second wheel-clip extending radially inwardly from the second edge of the frame relative to the arcuately-shaped longitudinal axis. The device includes a traction portion disposed along at least a portion of the outer surface, the traction portion extending radially outwardly from the outer surface relative to the arcuately-shaped longitudinal axis.

Abstract: An administrator installs a key management agent on a previously approved client machine. The agent is started on the client machine, which posts requests for keys to a central key management service. The central key management service logs requests posted to it by clients, and checks for existing pre-approval records. If none are found, a message is typically sent to an approver for the requesting client machine. When a request is verified as approved, the request is flagged for further processing. The supported systems continuously or periodically look for records flagged for processing, use requests to generate keys and other appropriate elements for the requesting client machine, and post keys and other elements to the key management database. The key management agent polls the central key management service periodically until finding the expected key file, which it downloads and installs into a protected file location on the client machine.

Abstract: The present invention is drawn to the use of the compounds highlighted in Tables 1 & 2 and analogs thereof, for enhancing IR-mediated cellular cannibalism in cancer cells. Said compounds are herein called “enhancers of IR-mediated cellular cannibalism”. They can be used to enhance tumor immunogenicity and/or to induce a significant protective anticancer immune response in subjects that will receive or that have received a radiotherapy treatment. In other words, said compounds can be used to potentiate a radiotherapy treatment in a subject in need thereof. Said compounds are preferably chosen in the group consisting of: Mebhydroline 1,5-napthalene disulfonate salt, Flurbiprofen, Minaprine dihydrochloride, Myricetin, Digoxin, Digitoxin, Lanatoside, LOPA87, VP331, RN-1-026, SG6163F, VP450, and VP43.

Abstract: A programmable, deformable incident-energy shaper comprising: a base having top and bottom surfaces with a perforation there-between; a protrusion connected to, and extending outwardly from, a center of the top surface; a deformable layer firmly attached to the base's perimeter and to a tip of the protrusion such that a majority of the deformable layer is suspended in free space between the tip and the perimeter, wherein the deformable layer is configured to flex inwardly or outwardly, and wherein the perforation provides a fluid channel to ambient fluid; and an actuator, operatively coupled to the deformable layer and configured to cause the deformable layer to flex inwardly or outwardly upon command.

Abstract: Water-soluble films, water-soluble unit dose articles, and related methods of making and using the same.

Abstract: Concepts for scaling a processing resource of a security information and event management system for processing a set of security events are presented. One example comprises identifying an event property of a set of security events, then assessing the identified event property against a predetermined rule. The method then comprises, in response to the assessed event property satisfying the predetermined rule, scaling a processing resource for processing the set of security events based on the predetermined rule.

Abstract: A method for leak detection in a system including a compressor. A first pressure differential is determined in the system via a first pressure differential indicator (PDI). The first pressure differential is converted into a first flow measurement. A second flow measurement is determined downstream of the compressor using a second PDI. The first flow measurement and the second flow measurement are compared to determine whether a leak exists between the first PDI and the second PDI.

Abstract: A carriage for transporting a child comprising: a chassis; a plurality of ground bearing wheels; a detachable cradle for supporting a child; a system for controlling environmental conditions within the cradle, the system having at least one electrical component for altering an environmental condition disposed on or in the cradle and at least one input means for controlling the or each electrical component disposed on or in the chassis. In the first aspect the carriage comprises a connector assembly for detachably mounting the cradle in different configurations wherein the cradle faces away from, or toward, a carriage operator, the connector and co-locating connector providing an electrical connection between the or each electrical component and the control panel in either configuration. In a second aspect, the canopy is movable by an electric motor. In a third aspect, the cradle is pivotable between a reclined and inclined position.

Abstract: Provided are ex vivo systems and methods of predicting the response of a drug or other agent on a tissue. In some embodiments, the systems and methods comprise cutting a tissue into tissue fragments, adding a drug or other agent to the tissue fragments based on an estimated tumor content, and performing an ex vivo measurement on the tissue fragments.

Abstract: A watercraft includes a hull, an opening extending vertically through the hull, and a support assembly configured to mount a propulsion mechanism to the watercraft. The hull at least partially defines the opening. The support assembly includes a rightward support device attached to the hull, positioned between a forward portion of the opening and a rearward portion of the opening, and at least partially defining a right lateral portion of the opening. The support assembly further includes a leftward support device attached to the hull, positioned between the forward portion of the opening and the rearward portion of the opening, and at least partially defining a left lateral portion of the opening.

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

Abstract: A system and method for creating, managing, and displaying 3D digital collectibles comprising a virtual, three dimensional, n-sided structure including a digital media file or set of digital media files representing an event rendered on a representation of at least a first surface thereof, and data relating to the event rendered on at least a second surface thereof and other content on one or more other surfaces, where the digital media file may be video clip of the event that can be played automatically via a media player associated with the display.

Abstract: A method for reprocessing a patient positing system, the system comprising inflatable device and a high-friction pad configured to attach to the inflatable device. The method includes removing the high-friction pad from the inflatable device, at least one of cleaning or sterilizing the inflatable device, and providing a replacement for at least one component of the patient positioning system.

Abstract: Provided herein is a method of preparation of a therapeutic formulation comprising extracellular vesicles packaged with fenretinide.

Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: A system and method for detecting faulty engine anti-ice sensor is disclosed and may include obtaining first pressure data representing a first pressure over a period of time at a first engine anti-ice pressure sensor on an aircraft engine. The method may further include obtaining second pressure data representing a second pressure over the period of time at a second engine anti-ice pressure sensor on the aircraft engine. The method may also include generating a variance value based at least partially on a variance of a difference between the first pressure data and the second pressure data. The method may include providing an indication that liquid is within the first engine anti-ice pressure sensor or the second engine anti-ice pressure sensor when the variance value exceeds a threshold.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: A computer-implemented method for sharing information about a subject without disclosing identification information of the subject includes comparing, by a computer system, a third set of data with a fourth set of data. The third set of data is converted by a transformation from a first set of data. The first set of data comprises identification information of a first subject. The fourth set of data is converted by the transformation from a second set of data. The second set of data comprises identification information of a second subject. The transformation renders the first subject unidentifiable from the third set of data and the second subject unidentifiable from the fourth set of data. The computer-implemented method also determines, by the computer system, that the first subject corresponds to the second subject when the third set of data corresponds to the fourth set of data.