Abstract: Disclosed herein are heterocyclic compounds that may be used as STING modulators, the process for synthesis and to the use of such compounds in treatment of various diseases including cancers.

Abstract: Disclosed herein are compounds that inhibit KRas G12C, pharmaceutical compositions, methods of preparation and uses thereof.

Abstract: Disclosed herein is a compound of Formula (I) having the following structure for activating T cells, promoting T cell proliferation, and/or exhibiting antitumor activity, a method of using the compounds disclosed herein for treating cancer, and a pharmaceutical composition comprising the same.

Abstract: Antibody-drug conjugate compounds comprising a linker and methods of using such compounds are provided.

Abstract: A flexible rolling belt-based conveying apparatus is provided, including a plurality of rolling body units (1). Each rolling body unit (1) includes a support (3). A power roller (2) is arranged above the support (3). Locomotion wheels (4) are arranged on two sides of the support. A chain link unit (5) is arranged in the middle of the support. A guide wheel (6) is mounted below the chain link unit (5). The chain link unit (5) includes a main chain link (11) and an auxiliary chain link (12). The main chain link (11) and the auxiliary chain link (12) are hinged respectively through a longitudinal hinge shaft (15) and a transverse hinge shaft (14). The longitudinal and transverse hinge shafts form a crisscross structure, and are in no contact at a center of the crisscross structure. The plurality of rolling body units (1) are sequentially connected front and back through the chain link units (5).

Abstract: Example systems, apparatus, articles of manufacture, and methods to implement hardware-accelerated intra frame encoding are disclosed. Example hardware-accelerated intra frame video encoders disclosed herein are VC3 compliant. Some example video encoders disclosed herein quantize alternating current (AC) coefficients of a macroblock of an input image frame using a small set of anchor quantization scale factors (QSFs), and interpolate between the resulting bit counts for the first anchor QSFs to determine an estimated QSF meets a target bit budget. Some example video encoders disclosed herein perform bit coding with a round-robin packing strategy that distributes the packing of encoded symbols among macroblocks and discards excess symbols to avoid exceeding the specified frame size. Some example video encoders disclosed herein are configurable via control circuitry and/or a driver that selects target bit budgets, anchor QSFs, encoding modes, etc.

Abstract: The present disclosure provides a detection method of wormlike micelles, and belongs to the technical field of analytical chemistry. In the present disclosure, z-ArN2+ is used as a chemical probe substance; a long-chain probe is added to a test solution for probing an interfacial region, and a short-chain probe is added to a surfactant-free control solution. A selectivity of the probe with different nucleophiles is determined by the above method, and a yield of an obtained product is measured by high-performance liquid chromatography (HPLC); and the wormlike micelles are detected by measuring the yield of the product using the selectivity of the short-chain probe to be converted into an interfacial mole number. The wormlike micelles are detected by chemical probes, and the chemical probes have a simple preparation method, a low cost, real-time detection, and broad prospects for use.

Abstract: Methods, systems, mediums, and devices use video processing with low latency bitstream distribution.

Abstract: Disclosed are an imidazo[2,1-f][1,2,4]triazin-4-amine derivative used as a TLR8 agonist or a stereoisomer thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing same. Further disclosed is a method for treating cancers using the imidazo[2,1-f][1,2,4]triazin-4-amine derivative or the stereoisomer thereof or the pharmaceutically acceptable salt thereof as a TLR8 agonist.

Abstract: A method for improving wheat resistance to Fusarium head blight (FHB) by genome editing is provided, and further provided is use of TaCIPK14 protein or related biomaterial thereto in the regulation of plant resistance to FHB; the TaCIPK14 protein is TaCIPK14-4A protein (SEQ ID NO: 4), TaCIPK14-4B protein (SEQ ID NO: 5), and/or TaCIPK14-4D protein (SEQ ID NO: 6). TaCIPK14 knockout mutant plants are successfully obtained by simultaneously editing three alleles of TaCIPK14 in wheat using CRISPR-Cas9 gene editing technology. The TaCIPK14 knockout mutant shows resistance to inoculation with FHB pathogens, and the results of evaluation of major agronomic traits confirm that the TaCIPK14 knockout mutant reserves the major agronomic traits.

Abstract: A multi-target tracking method with joint detection and re-identification based on feature decoupling in the field of multi-target tracking for solving low tracking accuracy problem caused by conflicts in optimization directions in the joint training process of detection and re-identification tasks and improving tracking performance, includes the steps of: preprocessing multi-target tracking dataset, extracting feature F from the processed images and labels by the backbone network; decoupling feature F in the channel and spatial dimensions to obtain feature Fdet suitable for detection tasks and feature Fid suitable for re-identification tasks respectively, obtaining the position of the target detection bounding box in the image based on Fdet subdivision detection branch; calculating the similarity matrix D based on Fid and IOU overlap level, and processing matching of the target detection bounding box in the image with the trajectory already existed by using D and Hungarian algorithm to finally obtain the tra

Abstract: A multi-target tracking method with joint detection and re-identification based on feature decoupling in the field of multi-target tracking for solving low tracking accuracy problem caused by conflicts in optimization directions in the joint training process of detection and re-identification tasks and improving tracking performance, includes the steps of: preprocessing multi-target tracking dataset, extracting feature F from the processed images and labels by the backbone network; decoupling feature F in the channel and spatial dimensions to obtain feature Fdet suitable for detection tasks and feature Fid suitable for re-identification tasks respectively, obtaining the position of the target detection bounding box in the image based on Fdet subdivision detection branch; calculating the similarity matrix D based on Fid and IOU overlap level, and processing matching of the target detection bounding box in the image with the trajectory already existed by using D and Hungarian algorithm to finally obtain the tra

Abstract: Systems, apparatus, articles of manufacture, and methods to perform parallel macroblock scan line decoding with error handling are disclosed. An example apparatus disclosed herein includes a first decoder circuit to decode a first macroblock scan line of an encoded video frame, the first decoder circuit to fetch the first macroblock scan line from memory based on a load balancing algorithm. The disclosed example apparatus also includes a second decoder circuit to decode a second macroblock scan line of the encoded video frame, the second macroblock scan line different from the first macroblock scan line, the second decoder circuit to fetch the second macroblock scan line from the memory based on the load balancing algorithm. In the disclosed example apparatus, the first decoder circuit is to decode the first macroblock scan line and the second decoder circuit is to decode the second macroblock scan line in parallel.

Abstract: Disclosed herein is a compound of Formula (I) for activating T cells, promoting T cell proliferation, and/or exhibiting antitumor activity, a method of using the compounds disclosed herein for treating cancer, and a pharmaceutical composition comprising the same.

Abstract: Disclosed herein is a compound of Formula (I) having the following structure for activating T cells, promoting T cell proliferation, and/or exhibiting antitumor activity, a method of using the compounds disclosed herein for treating cancer, and a pharmaceutical composition comprising the same.

Abstract: Disclosed herein is a compound of Formula (I), which is a DGKs inhibitor, for activating T cells, promoting T cell proliferation, and/or exhibiting antitumor activity, a method of using the compounds disclosed herein for treating cancer, and a pharmaceutical composition comprising the same.

Abstract: Provided is a display panel. The display panel includes: a first substrate and a second substrate disposed opposite to each other, and a liquid crystal layer disposed between the first substrate and the second substrate; wherein the first substrate comprises a first base substrate, a plurality of first signal lines and a plurality of second signal lines disposed on a side, close to the second substrate, of the first substrate; and the second substrate comprises a second base substrate, and a shielding layer disposed on a side, close to the first substrate, of the second base substrate.

Abstract: A motion estimation method and apparatus for magnetic resonance imaging and a magnetic resonance imaging system. The method includes: calculating a rigid body motion vector of a subject for each of a most recent N imaging excitations; according to pilot tone (PT) data of each channel acquired for the most recent N imaging excitations and N rigid body motion vectors calculated for the most recent N imaging excitations, calculating a linear transformation model for transforming from the PT data of each channel acquired for the most recent N imaging excitations to the N rigid body motion vectors; and for each subsequent imaging excitation, according to PT data of each channel acquired during an echo duration of each echo and the linear transformation model, calculating a rigid body motion vector of the subject for each echo of each imaging excitation.

Abstract: Provided herein are compounds having formulas (I) or (VII): or pharmaceutically acceptable salts, tautomers, isotopologues, stereoisomers, or prodrugs thereof, wherein the substituents are as described herein; ligand-drug conjugates and pharmaceutically acceptable salts or solvates thereof, wherein the ligand-drug conjugate comprises a residue of the compound provided here; and methods of treating cancer thereof.

Abstract: The present disclosure provides a display panel and a display device. The display panel includes: a substrate, a common electrode line, a gate line, a first insulating layer, a data line, a second insulating layer, a pixel electrode layer, a first orientation layer, a liquid crystal layer, a second orientation layer, and a common electrode layer; wherein an angle between an extending direction of the common electrode line and a rubbing direction of the first orientation layer ranges from 0 degrees to 30 degrees or from 60 degrees to 90 degrees, and an angle between an extending direction of the gate line and the rubbing direction of the first orientation layer ranges from 0 degrees to 30 degrees or from 60 degrees to 90 degrees.