Abstract: A tonneau cover has rectangular elements pivotally connected together. An automatic latch can be coupled to a first rectangular element end of one of the rectangular elements. A latch actuator can extend from the automatic latch to a first latch-rearward rectangular element. The first latch rearward element can be rearward of the first rectangular element end. Movement of the first latch-rearward rectangular element relative to the first rectangular element end, as the tonneau cover moves between closed and open positions, can move the latch actuator which moves the first automatic latch between the latched and unlatched configurations, respectively.

Abstract: A tonneau system comprising: (a) a plurality of tonneau sections; (b) a retraction system including: (i) a drive roller; (ii) a pulley spaced apart from the drive roller; (iii) a track extending from a location proximate to the drive roller to a location proximate to the pulley; and (iv) a line connected to the drive roller and one or more of the plurality of tonneau sections; wherein the line extends between the one or more of the plurality of tonneau sections and the driver roller when the plurality of tonneau sections are in the closed position, and the line extends from the one or more of the plurality of tonneau sections around the pulley and to the drive roller when the plurality of tonneau sections are in the stored position.

Abstract: An assembly for opening and closing a tonneau cover. The assembly having a plate; a latch in communication with the plate, the latch having a finger that is adapted to engage the tonneau cover; and a shaft that is connected to the plate at one end, and at another end, the shaft has a pin that is adapted to engage a slot defined in the latch. Application of a force on the plate in a first direction causes the plate to move in the first direction, which causes the latch to move in a second direction so that the tonneau cover is moved into a closed configuration. Removal of the force from the plate causes the plate to move in a third direction, which causes the latch to move in a fourth direction so that the tonneau cover is moved into an open configuration.

Abstract: A tonneau cover has rectangular elements pivotally connected together. An automatic latch can be coupled to a first rectangular element end of one of the rectangular elements. A latch actuator can extend from the automatic latch to a first latch-rearward rectangular element. The first latch rearward element can be rearward of the first rectangular element end. Movement of the first latch-rearward rectangular element relative to the first rectangular element end, as the tonneau cover moves between closed and open positions, can move the latch actuator which moves the first automatic latch between the latched and unlatched configurations, respectively.

Abstract: Detection systems and methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g., a surface acoustic wave sensor such as, e.g., a shear horizontal surface acoustic wave sensor (e.g., a LSH-SAW sensor). A variety of techniques for modifying the effective mass of the target biological analytes in sample material are disclosed, including fractionating or disassembling the target biological analytes in the sample material (e.g., lysing the target biological analyte), adding a detectable mass to the target biological analyte or enhancing coupling of the target biological analyte (e.g., through the use of magnetic particles), exposing the sample material to a reagent that causes a change in at least detectable physical property in the sample material if the target biological analyte is present (e.g.

Abstract: Detection cartridges and associated components, as well as methods of using the same that provide sample materials to a sensor for detection are disclosed. Among the components that may be used in connection with the detection cartridges of the present invention are, e.g., input modules, fluid flow front control features, and volumetric flow rate control features. The modules may include one or more chambers containing different constituents for mixing and/or delivery into a detection cartridge.

Abstract: A method of manufacturing a moldable microneedle array (54) is described comprising providing a negative mold insert (44) characterized by a negative image of microneedle topography wherein at least one negative image of a microneedle is characterized by an aspect ratio of between about 2 to 1 and about 5 to 1. The negative mold insert (44) is used to define a structured surface of a negative mold cavity (42). Molten plastic material is injected into the heated negative mold cavity. The molten plastic material is subsequently cooled and detached from the mold insert to provide a molded microneedle array (54). One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue through the skin.

Abstract: A medical device is described, comprising an array (10) comprising microstructures (12) configured to penetrate the stratum corneum upon impact, and a connection member (20) affixed to the array in a one piece construction, the connection member configured to reversibly connect the medical device to an applicator. The medical devices of the invention may be used in methods requiring the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue through the skin. In use, it is generally desirable to provide the microstructures at a height sufficient to penetrate the stratum corneum. A medical kit is also described, comprising the foregoing medical device and a tray (34) configured to hold the medical device.

Abstract: Methods and devices for thermal processing of multiple samples at the same time are disclosed. The assemblies include carriers and sample processing devices with process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas. The carriers may be used to apply selective compression to the sample processing devices.

Abstract: Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas.

Abstract: Apparatus and methods for positioning the process chambers of microfluidic sample processing devices in the proper focal plane of a microplate reader are disclosed. The apparatus and methods may be adaptable to position the sample processing devices at different heights as may be necessary for processing in different microplate readers. A positioning device is used in connection with the sample processing device to locate the process chambers within the focal plane of the microplate reader.