Abstract: A promotional piece with a pop-up feature is provided to effectively capture the attention of consumers. The promotional piece with a pop-up feature is movable from a closed to an open position and includes a backing substrate and a presentation substrate. The presentation substrate is selectively joined to the backing substrate by any suitable means. When the promotional piece with a pop-up feature is moved from the closed to the open position, at least a portion of the presentation substrate is caused to project away from the underlying portion of the presentation substrate. A high speed in-line manufacturing method for producing a plurality of promotional pieces with a pop-up feature is also provided. The promotional piece with a pop-up feature may be used in various applications, such as product packaging, promotional or advertising mailers, greeting cards, announcement cards, and other like applications.