Patents by Inventor Chafiq Hamdouchi

Chafiq Hamdouchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors
    Patent number: 11453673
    Abstract: The present invention provides a compound of Formula I: wherein R1 is methyl, ethyl or cyclopropyl; R2 is hydrogen, methyl, or ethyl; R3 is methyl or AA; and R4 is C2-C4 alkyl, BB; or a pharmaceutically acceptable salt thereof; for use as a PDE1 inhibitor.
    Type: Grant
    Filed: January 13, 2019
    Date of Patent: September 27, 2022
    Assignee: ELI LILLY AND COMPANY
    Inventors: Nicholas Paul Camp, Chafiq Hamdouchi, Jayana Pankaj Lineswala, John Richard Morphy, Qing Shi
  • [1,2,4]TRIAZOLO[4,3-A]PYRAZIN-8-ONE DERIVATIVES
    Publication number: 20200399277
    Abstract: The present invention provides a compound of Formula I: wherein R1 is methyl, ethyl or cyclopropyl; R2 is hydrogen, methyl, or ethyl; R3 is methyl or AA; and R4 is C2-C4 alkyl, BB; or a pharmaceutically acceptable salt thereof; for use as a PDE1 inhibitor.
    Type: Application
    Filed: January 13, 2019
    Publication date: December 24, 2020
    Inventors: Nicholas Paul CAMP, Chafiq HAMDOUCHI, Jayana Pankaj LINESWALA, John Richard MORPHY, Qing SHI
  • Isopropyl triazolo pyridine compounds
    Patent number: 9809592
    Abstract: The present invention provides a compound of the Formula (I) below: Wherein R1 is selected from the group consisting of H, CH3, CN, CH2CN, C(CH3)2CN, and F; R2 is selected from the group consisting of H, O(C1-C3alkyl)R5, CH2CN, and CN; R3 is selected from the group consisting of H, OCH3, CN, C(CH3)2CN, and CH2CN; R4 is selected from the group consisting of H and CH3; R5 is selected from the group consisting of H, CN, C(CH3)2CN, OCH3, S(O)2CH3, and C(CH3)2OH; provided that at least one selected from the group consisting of R1, R2, R3 and R4 is H; or a pharmaceutically acceptable salt thereof, methods of treating diabetes using the compound and a process for preparing the compound.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: November 7, 2017
    Assignee: Eli Lilly and Company
    Inventors: Chafiq Hamdouchi, Pranab Maiti, Anne Reifel Miller
  • Phenyl-triazolo-pyridine compounds
    Patent number: 9617263
    Abstract: The present invention provides a compound of the Formula (I) below: wherein R1 is selected from the group consisting of H, CH3, CN, —CH2CN, —C(CH3)2CN, F, Cl, and Br; R2 is selected from the group consisting of H, —O(C1-C3alkylene)R4, —CH2CN, CN, —OCH3, CF2, —C(CH3)2CN, —C(CH3)2, —S(O)2CH3, —S(O)2NH2, and —OCF2; R3 is selected from the group consisting of H, CH3, and —OCH3; and R4 is selected from the group consisting of H, —C(CH3)2CN, —OCH3, —S(O)2CH3, CN, and —C(CH3)2OH; or a pharmaceutical salt thereof, methods of treating type two diabetes using the compound and a process for preparing the compound.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: April 11, 2017
    Assignee: Eli Lilly and Company
    Inventors: Chafiq Hamdouchi, Pranab Maiti
  • PHENYL-TRIAZOLO-PYRIDINE COMPOUNDS
    Publication number: 20170029420
    Abstract: The present invention provides a compound of the Formula (I) below: wherein R1 is selected from the group consisting of H, CH3, CN, —CH2CN, —C(CH3)2CN, F, Cl, and Br; R2 is selected from the group consisting of H, —O(C1-C3alkylene)R4, —CH2CN, CN, —OCH3, CF2, —C(CH3)2CN, —C(CH3)2, —S(O)2CH3, —S(O)2NH2, and —OCF2; R3 is selected from the group consisting of H, CH3, and —OCH3; and R4 is selected from the group consisting of H, —C(CH3)2CN, —OCH3, —S(O)2CH3, CN, and —C(CH3)2OH; or a pharmaceutical salt thereof, methods of treating type two diabetes using the compound and a process for preparing the compound.
    Type: Application
    Filed: January 6, 2015
    Publication date: February 2, 2017
    Applicant: Eli Lily and Company
    Inventors: Chafiq Hamdouchi, Pranab Maiti
  • ISOPROPYL TRIAZOLO PYRIDINE COMPOUNDS
    Publication number: 20160333005
    Abstract: The present invention provides a compound of the Formula (I) below: Wherein R1 is selected from the group consisting of H, CH3, CN, CH2CN, C(CH3)2CN, and F; R2 is selected from the group consisting of H, O(C1-C3alkyl)R5, CH2CN, and CN; R3 is selected from the group consisting of H, OCH3, CN, C(CH3)2CN, and CH2CN; R4 is selected from the group consisting of H and CH3; R5 is selected from the group consisting of H, CN, C(CH3)2CN, OCH3, S(O)2CH3, and C(CH3)2OH; provided that at least one selected from the group consisting of R1, R2, R3 and R4 is H; or a pharmaceutically acceptable salt thereof, methods of treating diabetes using the compound and a process for preparing the compound.
    Type: Application
    Filed: January 6, 2015
    Publication date: November 17, 2016
    Applicant: ELI LILLY AND COMPANY
    Inventors: Chafiq Hamdouchi, Pranab Maiti, Anne Reifel Miller
  • Triazolo-pyridine compound
    Patent number: 9120793
    Abstract: The present invention provides compounds of the formula wherein R1 is selected from the group consisting of H and CH3; R2 is selected from the group consisting of H and CH3; R3 is selected from the group consisting of H, C1-C3 alkyl, O(CH2)3SO2CH3, O(CH2)2OCH3, O(CH2)2C(CH3)2OH, CN, and OCF2; or a pharmaceutical salt thereof, methods of treating diabetes, intermediates, and a process for preparing compounds of the invention.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: September 1, 2015
    Assignee: Eli Lilly and Company
    Inventor: Chafiq Hamdouchi
  • NOVELTRIAZOLO-PYRIDINE COMPOUND
    Publication number: 20150166535
    Abstract: The present invention provides compounds of the formula wherein R1 is selected from the group consisting of H and CH3; R2 is selected from the group con+sisting of H and CH3; R3 is selected from the group consisting of H, C1-C3 alkyl, O(CH2)3SO2CH3, O(CH2)2OCH3, O(CH2)2C(CH3)2OH, CN, and OCF2; or a pharmaceutical salt thereof, methods of treating diabetes, intermediates, and a process for preparing compounds of the invention.
    Type: Application
    Filed: December 4, 2014
    Publication date: June 18, 2015
    Inventor: Chafiq Hamdouchi
  • Spiropiperidine compounds
    Patent number: 8822486
    Abstract: A compound of the formula: or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition, and a method for treating diabetes.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: September 2, 2014
    Assignee: Eli Lilly and Company
    Inventors: Chafiq Hamdouchi, Jayana Pankaj Lineswala, Pranab Maiti
  • 1,2,3,4-tetrahydroqinoline derivative useful for the treatment of diabetes
    Patent number: 8431706
    Abstract: The present invention provides a compound of the formula below or a pharmaceutical salt thereof, methods of treating diabetes using the compound and a process for preparing the compound.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: April 30, 2013
    Assignee: Eli Lilly and Company
    Inventor: Chafiq Hamdouchi
  • Spiropiperidine compounds
    Patent number: 8383642
    Abstract: A compound of the formula: or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition, and a method for treating diabetes.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: February 26, 2013
    Assignee: Eli Lilly and Company
    Inventors: Chafiq Hamdouchi, Jayana Pankaj Lineswala, Pranab Maiti
  • NOVEL 1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVE USEFUL FOR THE TREATMENT OF DIABETES
    Publication number: 20130045990
    Abstract: The present invention provides a compound of the formula below or a pharmaceutical salt thereof, methods of treating diabetes using the compound and a process for preparing the compound.
    Type: Application
    Filed: August 9, 2012
    Publication date: February 21, 2013
    Applicant: ELI LILLY AND COMPANY
    Inventor: Chafiq Hamdouchi
  • NOVEL SPIROPIPERIDINE COMPOUNDS
    Publication number: 20120220616
    Abstract: A compound of the formula: or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition, and a method for treating diabetes.
    Type: Application
    Filed: November 19, 2010
    Publication date: August 30, 2012
    Applicant: ELI LILLY AND COMPANY
    Inventors: Chafiq Hamdouchi, Jayana Pankaj Lineswala, Pranab Maiti
  • Thiazole pyrazolopyrimidines CRF1 receptor antagonists
    Patent number: 8030304
    Abstract: The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: October 4, 2011
    Assignee: Eli Lilly and Company
    Inventors: Zhaogen Chen, Chafiq Hamdouchi Hamdouchi, Erik James Hembre, Philip Arthur Hipskind, Jason Kenneth Myers, Takako Takakuwa, James Lee Toth
  • Novel Spiropiperidine Compounds
    Publication number: 20110092531
    Abstract: A compound of the formula: or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition, and a method for treating diabetes.
    Type: Application
    Filed: October 11, 2010
    Publication date: April 21, 2011
    Applicant: ELI LILLY AND COMPANY
    Inventors: Chafiq Hamdouchi, Jayana Pankaj Lineswala, Pranab Maiti
  • Thiazole pyrazolopyrimidines CRF1 receptor antagonists
    Publication number: 20100222339
    Abstract: The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.
    Type: Application
    Filed: September 17, 2007
    Publication date: September 2, 2010
    Inventors: Zhaogen Chen, Chafiq Hamdouchi Hamdouchi, Erik James Hembre, Philip Arthur Hipskind, Jason Kenneth Myers, Takako Takakuwa, James Lee Toth
  • THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS
    Publication number: 20100022560
    Abstract: The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and the use of such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.
    Type: Application
    Filed: September 13, 2007
    Publication date: January 28, 2010
    Inventors: Zhaogen Chen, Chafiq Hamdouchi Hamdouchi, Erik James Hembre, Philip Arthur Hipskind, Shaojuan Jia, James Lee Toth
  • KINASE INHIBITORS
    Publication number: 20090318443
    Abstract: The present invention provides kinase inhibitors of Formula I.
    Type: Application
    Filed: July 27, 2009
    Publication date: December 24, 2009
    Inventors: Rosanne Bonjouklian, Chafiq Hamdouchi Hamdouchi, Chuan Shih, Alfonso De Dios, Miriam Filadelfa Del Prado, Carlos Jaramillo Aguado, Pramila Kotiyan, Mary Margaret Mader, Sheila Pleite Selgas, Concepcion Sanchez-Martinez
  • Imidazopyridazine compounds
    Patent number: 7612067
    Abstract: The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I): pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disorders and neurological diseases.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: November 3, 2009
    Assignee: Eli Lilly and Company
    Inventors: Heather Janelle Barbosa, Elizabeth Aaron Collins, Chafiq Hamdouchi, Erik James Hembre, Philip Arthur Hipskind, Richard Duane Johnston, Jianliang Lu, Michael John Rupp, Takako Takakuwa, Richard Craig Thompson
  • Kinase inhibitors
    Patent number: 7582652
    Abstract: The present invention provides kinase inhibitors of Formula I.
    Type: Grant
    Filed: January 25, 2005
    Date of Patent: September 1, 2009
    Assignee: Eli Lilly and Company
    Inventors: Rosanne Bonjouklian, Chafiq Hamdouchi, Chuan Shih, Alfonso De Dios, Miriam Filadelfa del Prado, Carlos Jaramillo Aguado, Pramila Kotiyan, Mary Margaret Mader, Sheila Pleite Selgas, Concepcion Sanchez-Martinez