Patent number: 6358971
Abstract: The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus.
wherein:
A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl;
R is hydrogen, COR4, or COCF3;
X is N—OH, O, or CHR1;
R1 is hydrogen, halo, CN, C1-C4 alkyl, —C≡CH, CO(C1-C4 alkyl), CO2(C1-C4 alkyl), or CONR2R3;
R2 and R3 are independently hydrogen or C1-C4 alkyl;
A′ is hydrogen, halo, C1-C6 alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR4, S(O)nR4, or a group of the formula
R4 is C1-C6 alkyl, phenyl, or substituted phenyl;
n is 0, 1, or 2;
R5 is independently at each occurrence hydrogen or halo;
m is 1, 2, 3, or 4; and
R6 is hydrogen, halo, CF3, OH, CO2H, NH2, NO2, CONHOCH3, C1-C4 alkyl, or CO2(C1-C4 alkyl), C1-C4 alkoxy;
or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
December 4, 2000
Date of Patent:
March 19, 2002
Assignee:
Eli Lilly and Company
Inventors:
Jesus Ezquerra-Carrera, Joseph Michael Gruber, Chafiq Hamdouchi Hamdouchi, Richard Elmer Holmes, Wayne Alfred Spitzer
