Patents by Inventor Chandan K. Sen

Chandan K. Sen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220249821
    Abstract: An apparatus for delivering an agent to a target recipient includes a planar substrate having a first surface and a second surface, a reservoir defined in the first surface of the planar substrate, and a plurality of microstructures projecting from the second surface of the planar substrate. Each of the plurality of microstructures includes a delivery channel that extends from the reservoir to a channel opening defined in an exterior surface of the microstructure. In some embodiments, a needle with microchannels can be fabricated using a silicon wafer. A primary channel is etched into the wafer, and then a second silicon wafer can be bonded on top of the initial wafer. Microchannels can be formed from the primary channel to a surface of the wafer using deep reactive ion etching. The diameter of the microchannels may be chosen for drug delivery. The illustrative diameter of the microchannels is 4 micrometers.
    Type: Application
    Filed: July 17, 2020
    Publication date: August 11, 2022
    Inventors: Chandan K. SEN, Yi XUAN
  • Publication number: 20210299200
    Abstract: The present disclosure provides a fermented papaya preparation comprising carbohydrate, protein lipid, potassium, and water, and methods of use thereof.
    Type: Application
    Filed: December 10, 2020
    Publication date: September 30, 2021
    Applicant: OSATO INTERNATIONAL INC.
    Inventors: Yukiyasu Hayashi, Chandan K. Sen
  • Patent number: 11077045
    Abstract: Methods of using Shilajit or its individual components, or a combination of two or more of these components, to improve skin microperfusion, to upregulate ECM related genes in the skin, to increase endothelial cell migration and growth of blood vessels, and thus to improve skin health are presented herein.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: August 3, 2021
    Assignee: Natreon, Inc.
    Inventors: Chandan K. Sen, Sanyasi R. Kalidindi
  • Patent number: 10980863
    Abstract: Methods, compositions, and treatment protocols for treating ischemic wounds and inflammatory conditions in a patient. The treatment protocols comprise or consist of using a modified collagen gel (MCG) to promote healing of ischemic wounds and reduce inflammation at the wound site and in other inflammatory conditions. The modified collagen gel comprises generally a dispersion of collagens in an aqueous matrix comprising water and glycerine, where the amount of Type I collagen is greater than the amount of Type II and Type III collagens in the gel.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: April 20, 2021
    Assignee: Southwest Technologies, Inc.
    Inventors: Edward I. Stout, Chandan K. Sen
  • Publication number: 20200138892
    Abstract: Methods of treating symptoms of type 2 diabetes in a human subject by administering a composition comprising urolithin A and urolithin B, are provided. Methods of treating symptoms of type 2 diabetes and metabolic syndrome in a human subject by administering a composition comprising neem extract are provided.
    Type: Application
    Filed: November 4, 2019
    Publication date: May 7, 2020
    Applicant: Natreon, Inc.
    Inventors: Muruganandam A. Veeraragavan, Chandan K. Sen, Sanyasi R. Kalidindi
  • Publication number: 20200009230
    Abstract: Methods, compositions, and treatment protocols for treating ischemic wounds and inflammatory conditions in a patient. The treatment protocols comprise or consist of using a modified collagen gel (MCG) to promote healing of ischemic wounds and reduce inflammation at the wound site and in other inflammatory conditions. The modified collagen gel comprises generally a dispersion of collagens in an aqueous matrix comprising water and glycerine, where the amount of Type I collagen is greater than the amount of Type II and Type III collagens in the gel.
    Type: Application
    Filed: September 16, 2019
    Publication date: January 9, 2020
    Inventors: Edward I. Stout, Chandan K. Sen
  • Publication number: 20190388322
    Abstract: Methods of using Shilajit or its individual components, or a combination of two or more of these components, to improve skin microperfusion, to upregulate ECM related genes in the skin, to increase endothelial cell migration and growth of blood vessels, and thus to improve skin health are presented herein.
    Type: Application
    Filed: June 26, 2018
    Publication date: December 26, 2019
    Applicant: Natreon, Inc.
    Inventors: Chandan K. Sen, Sanyasi R. Kalidindi
  • Patent number: 10504624
    Abstract: Disclosed are systems and methods for automated monitoring of the size, area or boundary of chronic wound images. The disclosure includes use of a probability map that measures the likelihood of wound pixels belonging to granulation, slough or eschar, which can then be segmented using any standard segmentation techniques. Measurement of the wound size, area or boundary occurs automatically and without user input related to outlining, filling in, or making measurement lines over the image on a display.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: December 10, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Metin N. Gurcan, Chandan K. Sen, Gayle Gordillo
  • Publication number: 20190247234
    Abstract: Antimicrobial dressings for prevention and mitigation of biofilm and bacterial infection by an applied electric current are provided. Methods of making the dressings and methods of applying an electric current to promote the wound healing process are also disclosed.
    Type: Application
    Filed: October 20, 2017
    Publication date: August 15, 2019
    Inventors: Shaurya PRAKASH, Vishwanath V. SUBRAMANIAM, Molly Marie BENNETT, Chandan K. SEN, Travis Hamilton JONES, Emily Quinn ROSENTHAL, Shomita STEINER, Sashwati ROY, Joseph Dean WEST, Piya Das GHATAK
  • Patent number: 10238629
    Abstract: The present invention provides methods to reduce the number and severity of hot flashes utilizing tocotrienols. In particular, symptoms of perimenopause and menopause may be treated using the present methods. The present invention also provides methods to increase tissue concentrations of tocotrienols.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: March 26, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Chandan K. Sen, Sashwati Roy, Savita Khanna, Cameron Rink
  • Publication number: 20180226154
    Abstract: Disclosed are systems and methods for automated monitoring of the size, area or boundary of chronic wound images. The disclosure includes use of a probability map that measures the likelihood of wound pixels belonging to granulation, slough or eschar, which can then be segmented using any standard segmentation techniques. Measurement of the wound size, area or boundary occurs automatically and without user input related to outlining, filling in, or making measurement lines over the image on a display.
    Type: Application
    Filed: April 10, 2018
    Publication date: August 9, 2018
    Inventors: Metin N. Gurcan, Chandan K. Sen, Gayle Gordillo
  • Patent number: 9990472
    Abstract: Disclosed are systems and methods for automated monitoring of the size, area or boundary of chronic wound images. The disclosure includes use of a probability map that measures the likelihood of wound pixels belonging to granulation, slough or eschar, which can then be segmented using any standard segmentation techniques. Measurement of the wound size, area or boundary occurs automatically and without user input related to outlining, filling in, or making measurement lines over the image on a display.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: June 5, 2018
    Assignee: Ohio State Innovation Foundation
    Inventors: Metin N. Gurcan, Chandan K. Sen, Gayle Gordillo
  • Patent number: 9901596
    Abstract: A method of using dibenzo-alpha-pyrones (DBPs) is provided wherein a subject is administered one or more of the aforementioned resulting in decreased body weight gain. In an embodiment, a 3-OH-DBP, 3,8-(OH)2-DBP, or a combination thereof is administered to an individual to control body weight gain.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: February 27, 2018
    Assignee: Natreon, Inc.
    Inventor: Chandan K. Sen
  • Publication number: 20180000905
    Abstract: Methods, compositions, and treatment protocols for treating ischemic wounds and inflammatory conditions in a patient. The treatment protocols comprise or consist of using a modified collagen gel (MCG) to promote healing of ischemic wounds and reduce inflammation at the wound site and in other inflammatory conditions. The modified collagen gel comprises generally a dispersion of collagens in an aqueous matrix comprising water and glycerine, where the amount of Type I collagen is greater than the amount of Type II and Type III collagens in the gel.
    Type: Application
    Filed: December 30, 2015
    Publication date: January 4, 2018
    Inventors: Edward I. STOUT, Chandan K. SEN
  • Publication number: 20170333389
    Abstract: Methods for reducing blood clotting in a subject are provided, including methods to reduce the risk of and/or treat blot clotting pathologies. Also provided are compositions useful to reduce the risk or treat blood clotting pathologies.
    Type: Application
    Filed: July 19, 2017
    Publication date: November 23, 2017
    Applicant: The Ohio State University
    Inventors: Chandan K. Sen, Cameron Rink, Sashwati Roy, Savita Khanna
  • Publication number: 20160284084
    Abstract: Disclosed are systems and methods for automated monitoring of the size, area or boundary of chronic wound images. The disclosure includes use of a probability map that measures the likelihood of wound pixels belonging to granulation, slough or eschar, which can then be segmented using any standard segmentation techniques. Measurement of the wound size, area or boundary occurs automatically and without user input related to outlining, filling in, or making measurement lines over the image on a display.
    Type: Application
    Filed: March 23, 2016
    Publication date: September 29, 2016
    Inventors: Metin N. Gurcan, Chandan K. Sen, Gayle Gordillo
  • Publication number: 20160220609
    Abstract: A method of using Purified Shilajit to promote steroidogenic activity in a mammal is provided.
    Type: Application
    Filed: September 9, 2014
    Publication date: August 4, 2016
    Applicant: Natreon, Inc.
    Inventor: Chandan K. Sen
  • Publication number: 20160213644
    Abstract: A method of using dibenzo-alpha-pyrones (DBPs) is provided wherein a subject is administered one or more of the aforementioned resulting in decreased body weight gain. In an embodiment, a 3-OH-DBP, 3,8-(OH)2-DBP, or a combination thereof is administered to an individual to control body weight gain.
    Type: Application
    Filed: September 9, 2014
    Publication date: July 28, 2016
    Applicant: Natreon, Inc.
    Inventor: Chandan K. Sen
  • Publication number: 20160184377
    Abstract: To confirm the safety of a fermented papaya preparation in type 2 diabetic patients while determining its in vivo effect on respiratory burst in human peripheral-blood mononuclear cells to find further health advantages for the type 2 diabetic patients. A respiratory burst activity promoter for improving the production of reactive oxygen species (ROS) induced by NADPH oxidase and promoting respiratory burst activity in type 2 diabetic patients, comprising a fermented papaya preparation as an active ingredient.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 30, 2016
    Applicant: OSATO INTERNATIONAL INC.
    Inventors: Yukiyasu Hayashi, Chandan K. Sen
  • Publication number: 20160184376
    Abstract: An object of the present invention is to confirm the safety of a fermented papaya preparation in type 2 diabetic patients while determining its effect on ATP production and mitochondria to find further health advantages for type 2 diabetic patients. The present invention provides an ATP production promoter for promoting ATP production in type 2 diabetic patients and a mitochondrial activity promoter for promoting mitochondrial activity in the patients, each comprising a fermented papaya product as an active ingredient. The present invention also provides an immunostimulant for type 2 diabetic patients, based on promoting ATP production and/or mitochondrial activity in type 2 diabetic patients, comprising a fermented papaya preparation as an active ingredient.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 30, 2016
    Applicant: OSATO INTERNATIONAL INC.
    Inventors: Yukiyasu Hayashi, Chandan K. Sen