Abstract: This invention is directed to pharmaceutical compositions comprising tocotrienol and the use of such compositions to treat non-alcoholic steatohepatitis.

Abstract: This invention is directed to a multilayered fabric that comprises an electrode bearing surface that is electrically connected to a voltage source, wherein upon application of a charge, the electrode bearing will generating an electric field to neutralize pathogens and other microorganisms coming in contact with the material.

Abstract: Compositions and methods are provided for promoting wound healing in a subject by administering a composition that enhances the expression of the protein nonselenocysteine-containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) in wound-edge tissues. In accordance with one embodiment such compositions are used in conjunction with known treatments for use on chronic wounds including in diabetic patients.

Abstract: Compositions and methods are provided for preparing an article that comprises an electroceutical material that comprises a redox pair of alternating metals that generate an electric current or field when exposed to an aqueous solution. In one embodiment filtering equipment including facial masks are prepared comprising the electroceutical materials.

Abstract: Compositions and methods are provided for treating an article that is susceptible to contamination by an antimicrobial-resistant microorganism, wherein the susceptible article is exposed to an optimized electric current or field. Methods to treat an individual in need of therapy are also provided, including for example, individuals having a bacterial, viral, fungal, or parasitic infection, or individuals having an antimicrobial-resistant microbial infection, e.g., in a wound, by applying a predetermined electric current to the individual. The methods disclosed herein can be used in conjunction with a therapeutic pharmaceutical composition comprising an antimicrobial agent such as an antifungal or antibiotic pharmaceutical.

Abstract: Compositions and methods are provided for reducing facial contracture and to alleviate deficits associated with thermal injury of the face, including ectropion (epithelial-ocular junction), eversion of the lip (epithelial-oral junction), and oral incompetence (drooling). In accordance with one embodiment such compositions are used in conjunction with known treatments for use on burn patients.

Abstract: Disclosed herein are compositions and in vitro and in vivo methods for reprogramming lymphatic tissue to induce the lymphatic tissue to form a lymphovenous anastomosis with an adjacent vessel of the venous system.

Abstract: Disclosed herein are compositions and in vitro and in vivo methods for reprogramming post-natal (adult and juvenile) tissue into insulinogenic cells. These compositions and methods are useful for a variety of purposes, including the development of diabetes therapies.

Abstract: Compositions and methods are provided for reprogramming demal fibroblasts to exhibit neurogenic properties including increased cell expression of NGF and Nt3 in vivo. In accordance with one embodiment such compositions are used in conjunction with standard treatment for use in treating neuropathic pain and stabilizing or stimulating production of PGP9.5+ mature nerve fiber in a diabetic patient’s tissues.

Abstract: Compositions and methods are provided for modifying the contents of exosomes released by target cells. In one embodiment cell targeted nanoparticles are used to deliver interference RNAs to the target cells which alter the packaging of exosomes released by the target cells.

Abstract: Compositions and methods are provided for promote wound healing in a subject by administering a miR-1 inhibitor to a wound on subject. In accordance with one embodiment such compositions are used in conjunction with known treatments for use on chronic wounds including in diabetic patients.

Abstract: An orthopedic system wherein a patient's brain is operably coupled to an actuation assembly for voluntarily moving a brace/limb of the patient between a number of desirable positions. An orthopedic brace, or one of more components thereof, which can be utilized with the orthopedic system.

Abstract: Technologies for fibers with nanotechnology is disclosed. In the illustrative embodiment, a preform is 3D printed with one or more sacrificial cores and one or more hollow channels. The preform is drawn into a fiber, and one or more metal core(s) is inserted into the hollow channel during the fiber draw. The fiber is then heated, breaking up the sacrificial cores into balls through capillary action. The fiber can be etched, exposing the balls made up of the sacrificial cores. The balls can be selectively etched, exposing the metal core(s) of the fiber. Additional embodiments are disclosed.

Abstract: Compositions and methods are provided for disrupting biofilms formed by microbial organisms. In accordance with one embodiment such compositions are used in conjunction with standard treatment for use on chronic wounds. In one embodiment the biofilm disrupting composition comprises a nuclease and aurine tricarboxylic acid. The biofilm disrupting compositions disclosed herein can be used in conjunction with a therapeutic pharmaceutical composition comprising standard antibiotics.

Abstract: Compositions and methods are provided for reprogramming dermal fibroblasts to exhibit vasculogenic properties including the ability to stimulate vasculogenesis in vivo. In accordance with one embodiment such compositions are used in conjunction with standard treatment for use on chronic wounds including in diabetic patients.

Abstract: An apparatus for delivering an agent to a target recipient includes a planar substrate having a first surface and a second surface, a reservoir defined in the first surface of the planar substrate, and a plurality of microstructures projecting from the second surface of the planar substrate. Each of the plurality of microstructures includes a delivery channel that extends from the reservoir to a channel opening defined in an exterior surface of the microstructure. In some embodiments, a needle with microchannels can be fabricated using a silicon wafer. A primary channel is etched into the wafer, and then a second silicon wafer can be bonded on top of the initial wafer. Microchannels can be formed from the primary channel to a surface of the wafer using deep reactive ion etching. The diameter of the microchannels may be chosen for drug delivery. The illustrative diameter of the microchannels is 4 micrometers.

Abstract: The present disclosure provides a fermented papaya preparation comprising carbohydrate, protein lipid, potassium, and water, and methods of use thereof.

Abstract: Methods of using Shilajit or its individual components, or a combination of two or more of these components, to improve skin microperfusion, to upregulate ECM related genes in the skin, to increase endothelial cell migration and growth of blood vessels, and thus to improve skin health are presented herein.

Abstract: Methods, compositions, and treatment protocols for treating ischemic wounds and inflammatory conditions in a patient. The treatment protocols comprise or consist of using a modified collagen gel (MCG) to promote healing of ischemic wounds and reduce inflammation at the wound site and in other inflammatory conditions. The modified collagen gel comprises generally a dispersion of collagens in an aqueous matrix comprising water and glycerine, where the amount of Type I collagen is greater than the amount of Type II and Type III collagens in the gel.

Abstract: Methods of treating symptoms of type 2 diabetes in a human subject by administering a composition comprising urolithin A and urolithin B, are provided. Methods of treating symptoms of type 2 diabetes and metabolic syndrome in a human subject by administering a composition comprising neem extract are provided.