Patents by Inventor Chandan K. Sen

Chandan K. Sen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10238629
    Abstract: The present invention provides methods to reduce the number and severity of hot flashes utilizing tocotrienols. In particular, symptoms of perimenopause and menopause may be treated using the present methods. The present invention also provides methods to increase tissue concentrations of tocotrienols.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: March 26, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Chandan K. Sen, Sashwati Roy, Savita Khanna, Cameron Rink
  • Publication number: 20180226154
    Abstract: Disclosed are systems and methods for automated monitoring of the size, area or boundary of chronic wound images. The disclosure includes use of a probability map that measures the likelihood of wound pixels belonging to granulation, slough or eschar, which can then be segmented using any standard segmentation techniques. Measurement of the wound size, area or boundary occurs automatically and without user input related to outlining, filling in, or making measurement lines over the image on a display.
    Type: Application
    Filed: April 10, 2018
    Publication date: August 9, 2018
    Inventors: Metin N. Gurcan, Chandan K. Sen, Gayle Gordillo
  • Patent number: 9990472
    Abstract: Disclosed are systems and methods for automated monitoring of the size, area or boundary of chronic wound images. The disclosure includes use of a probability map that measures the likelihood of wound pixels belonging to granulation, slough or eschar, which can then be segmented using any standard segmentation techniques. Measurement of the wound size, area or boundary occurs automatically and without user input related to outlining, filling in, or making measurement lines over the image on a display.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: June 5, 2018
    Assignee: Ohio State Innovation Foundation
    Inventors: Metin N. Gurcan, Chandan K. Sen, Gayle Gordillo
  • Patent number: 9901596
    Abstract: A method of using dibenzo-alpha-pyrones (DBPs) is provided wherein a subject is administered one or more of the aforementioned resulting in decreased body weight gain. In an embodiment, a 3-OH-DBP, 3,8-(OH)2-DBP, or a combination thereof is administered to an individual to control body weight gain.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: February 27, 2018
    Assignee: Natreon, Inc.
    Inventor: Chandan K. Sen
  • Publication number: 20180000905
    Abstract: Methods, compositions, and treatment protocols for treating ischemic wounds and inflammatory conditions in a patient. The treatment protocols comprise or consist of using a modified collagen gel (MCG) to promote healing of ischemic wounds and reduce inflammation at the wound site and in other inflammatory conditions. The modified collagen gel comprises generally a dispersion of collagens in an aqueous matrix comprising water and glycerine, where the amount of Type I collagen is greater than the amount of Type II and Type III collagens in the gel.
    Type: Application
    Filed: December 30, 2015
    Publication date: January 4, 2018
    Inventors: Edward I. STOUT, Chandan K. SEN
  • Publication number: 20170333389
    Abstract: Methods for reducing blood clotting in a subject are provided, including methods to reduce the risk of and/or treat blot clotting pathologies. Also provided are compositions useful to reduce the risk or treat blood clotting pathologies.
    Type: Application
    Filed: July 19, 2017
    Publication date: November 23, 2017
    Applicant: The Ohio State University
    Inventors: Chandan K. Sen, Cameron Rink, Sashwati Roy, Savita Khanna
  • Publication number: 20160284084
    Abstract: Disclosed are systems and methods for automated monitoring of the size, area or boundary of chronic wound images. The disclosure includes use of a probability map that measures the likelihood of wound pixels belonging to granulation, slough or eschar, which can then be segmented using any standard segmentation techniques. Measurement of the wound size, area or boundary occurs automatically and without user input related to outlining, filling in, or making measurement lines over the image on a display.
    Type: Application
    Filed: March 23, 2016
    Publication date: September 29, 2016
    Inventors: Metin N. Gurcan, Chandan K. Sen, Gayle Gordillo
  • Publication number: 20160220609
    Abstract: A method of using Purified Shilajit to promote steroidogenic activity in a mammal is provided.
    Type: Application
    Filed: September 9, 2014
    Publication date: August 4, 2016
    Applicant: Natreon, Inc.
    Inventor: Chandan K. Sen
  • Publication number: 20160213644
    Abstract: A method of using dibenzo-alpha-pyrones (DBPs) is provided wherein a subject is administered one or more of the aforementioned resulting in decreased body weight gain. In an embodiment, a 3-OH-DBP, 3,8-(OH)2-DBP, or a combination thereof is administered to an individual to control body weight gain.
    Type: Application
    Filed: September 9, 2014
    Publication date: July 28, 2016
    Applicant: Natreon, Inc.
    Inventor: Chandan K. Sen
  • Publication number: 20160184377
    Abstract: To confirm the safety of a fermented papaya preparation in type 2 diabetic patients while determining its in vivo effect on respiratory burst in human peripheral-blood mononuclear cells to find further health advantages for the type 2 diabetic patients. A respiratory burst activity promoter for improving the production of reactive oxygen species (ROS) induced by NADPH oxidase and promoting respiratory burst activity in type 2 diabetic patients, comprising a fermented papaya preparation as an active ingredient.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 30, 2016
    Applicant: OSATO INTERNATIONAL INC.
    Inventors: Yukiyasu Hayashi, Chandan K. Sen
  • Publication number: 20160184376
    Abstract: An object of the present invention is to confirm the safety of a fermented papaya preparation in type 2 diabetic patients while determining its effect on ATP production and mitochondria to find further health advantages for type 2 diabetic patients. The present invention provides an ATP production promoter for promoting ATP production in type 2 diabetic patients and a mitochondrial activity promoter for promoting mitochondrial activity in the patients, each comprising a fermented papaya product as an active ingredient. The present invention also provides an immunostimulant for type 2 diabetic patients, based on promoting ATP production and/or mitochondrial activity in type 2 diabetic patients, comprising a fermented papaya preparation as an active ingredient.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 30, 2016
    Applicant: OSATO INTERNATIONAL INC.
    Inventors: Yukiyasu Hayashi, Chandan K. Sen
  • Publication number: 20160166535
    Abstract: The present invention provides methods to reduce the number and severity of hot flashes utilizing tocotrienols. In particular, symptoms of perimenopause and menopause may be treated using the present methods. The present invention also provides methods to increase tissue concentrations of tocotrienols.
    Type: Application
    Filed: July 22, 2014
    Publication date: June 16, 2016
    Applicant: Ohio State Innovation Foundation
    Inventors: Chandan K. Sen, Sashwati Roy, Savita Khanna, Cameron Rink
  • Publication number: 20160095881
    Abstract: A method of using Shilajit or its individual components, or a combination of two or more of these components, to induce the body of a mammal, including that of a human, to synthesize new collagen and the related extracellular matrix proteins, thus promoting the health of all of the tissues and organs containing collagen and the related extracellular matrix proteins, including skin, connective tissue, muscle, cartilage, bone, and teeth and improve muscle building and regeneration, and/or treat collagen-related disorders is presented.
    Type: Application
    Filed: October 1, 2015
    Publication date: April 7, 2016
    Inventor: Chandan K. Sen
  • Publication number: 20140024624
    Abstract: Methods for reducing blood clotting in a subject are provided, including methods to reduce the risk of and/or treat blot clotting pathologies. Also provided are compositions useful to reduce the risk or treat blood clotting pathologies.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 23, 2014
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Chandan K. Sen, Sashwati Roy, Savita Khanna, Cameron Rink
  • Publication number: 20130309202
    Abstract: The present invention provides methods to improve liver function utilizing tocotrienols. In particular, various liver pathologies may be treated using the present methods, including cirrhosis, hepatitis, and sclerosing cholangtitis. The present invention also provides methods to increase tissue concentrations of tocotrienols.
    Type: Application
    Filed: May 20, 2013
    Publication date: November 21, 2013
    Applicant: The Ohio State University
    Inventors: Chandan K. Sen, Cameron L. Rink, Sashwati Roy, Savita Khanna
  • Publication number: 20120214863
    Abstract: Methods for modulating gene expression in a skin cell by administering to the cell an amount of a therapeutic composition in an amount sufficient to modulate the expression of miR-1, and therapeutic compositions and uses thereof are disclosed.
    Type: Application
    Filed: August 4, 2010
    Publication date: August 23, 2012
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Chandan K. Sen, Sashwati Roy, Shani Goldberg-Shilo
  • Publication number: 20120215080
    Abstract: An apparatus, system and method for measuring oxygen concentration for exciting and detecting oxygen-sensitive fluorescence in biological tissues to detect oxygen levels (e.g., the partial pressure of oxygen).
    Type: Application
    Filed: January 17, 2012
    Publication date: August 23, 2012
    Applicant: The Ohio State University
    Inventors: Chandan K. Sen, Savita Khanna, Sashwati Roy, Sangly P. Srinivas
  • Publication number: 20100113940
    Abstract: Appropriate assessment of wound oxygenation is critical to establish a diagnosis, to monitor the effect of the treatment, to guide the therapeutic process, to identify the presence of infection, and to predict the treatment outcome. Embodied systems and methods represent an enabling technology for noninvasive and objective assessment of wound tissue oxygenation. In addition to wound healing, disclosed embodiments offer low cost and portable avenues for noninvasive assessment of multiple clinical parameters for the detection and intervention of various malignancies in multiple soft tissue systems.
    Type: Application
    Filed: November 10, 2009
    Publication date: May 6, 2010
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Chandan K. Sen, Ronald X. Xu
  • Publication number: 20100049236
    Abstract: An agent for treating strokes in humans is tested in a non-human subject by selecting an agent for testing and by preparing a selected non-human subject. The preparation includes: inducing a stroke event by advancing a microwire through the arterial system of the subject to a selected intracranial target position, inserting a microcatheter along the microwire and delivering an embolic device to the target position, occluding the artery at the target position by deploying the embolic device, verifying the occlusion and repositioning the embolic device if needed. After a predetermined occlusion interval, reperfusion of the subject is simulated by removing the embolic device and commencing therapy with the selected agent. At appropriate intervals, the effect of the conducted course of therapy is assessed non-invasively until terminal evaluation. In particular aspects, the method involves occluding the middle cerebral artery through an access achieved via the basilar artery.
    Type: Application
    Filed: August 19, 2009
    Publication date: February 25, 2010
    Applicant: The Ohio State University Research Foundation
    Inventors: Chandan K. Sen, Cameron Rink, Sashwati Roy, Greg Christoforidis
  • Publication number: 20100035798
    Abstract: The invention provides methods, delivery devices, and compositions for topically oxygenating hypoxic tissue with a hemoglobin-based oxygen earner (HBOC), such as Oxyglobin (Oxyb) in order to promote wound healing and/or reducing hypoxia in post-harvest transplant tissue. The invention can be used, among other things, to stimulate angiogenesis and blood flow at a wound site, reduce wound dilation, and promote wound contraction, thereby increasing the overall rate of wound healing. The invention can also be used, among other things, to reduce oxidative stress in pre-implantation donor organ tissue, as well as stimulate the proliferation of granulation tissue, vessel growth, and promote epithelial healing in transplant tissue once it has been implanted.
    Type: Application
    Filed: September 17, 2007
    Publication date: February 11, 2010
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Chandan K. Sen, Sashwati Roy, Savita Khanna