Abstract: Systems and methods for determining parameters for image analysis are provided. One method includes obtaining ultrasound data of an object, generating an image of the object, and identifying a region of interest in the image. The method also includes determining a plurality of spatially varying parameters for image analysis of the region of interest using prior information for one or more objects of interest, including prior location information for the one or more objects of interest, and wherein the plurality of spatially varying parameters are determined for a plurality of sections of the region of interest and different for at least some of the plurality of sections. The method further includes using the plurality of spatially varying parameters for performing image analysis of the region of interest in the image to determine the location of the one or more objects of interest.

Abstract: A system, such as a computer aided design (CAD) system, is configured to abstract at least a portion of an integrated circuit (IC) design provided thereto. The system selects two signals of the IC and determines the respective sub-circuits ending at each of the signals, excluding the other sub-circuit when two sub-circuits intersect. It then identifies an intersection of the two sub-circuits and therefore establishes an abstraction therefrom. The abstraction replaces the circuit for verification purposes of the IC design. The process can repeat as may be necessary or until no two signals have sub-circuits that intersect. The process described for two signals is equally applicable to a plurality of signals for which the intersection is defined as the intersection of all the sub-circuits defined by the plurality signals. The abstraction allows for effective verification of portions of ICs as may be necessary.

Abstract: An improved process for the preparation of Pralatrexate which is less hazardous. The invention further relates to novel intermediates and process thereof useful for the preparation of Pralatrexate. The present invention also relates to a substantially pure Pralatrexate and a process for obtaining the same in high yield.

Abstract: Disclosed are alkali aluminosilicate glasses having unexpected resistance to indentation cracking. The glasses obtain this high resistance as a result of a high level of surface compression accompanied by a shallow depth of layer. The advantaged glasses show greater resistance to radial crack formation from Vickers indentation than glasses with the same compressive stress, but higher depths of layer.

Abstract: One or more aspects of the disclosure pertain to an article including a film disposed on a glass substrate, which may be strengthened, where the interface between the film and the glass substrate is modified, such that the article has an improved average flexural strength, and the film retains key functional properties for its application. Some key functional properties of the film include optical, electrical and/or mechanical properties. In one or more embodiments, the interface exhibits an effective adhesion energy of about less than about 4 J/m2. In some embodiments, the interface is modified by the inclusion of a crack mitigating layer containing an inorganic material between the glass substrate and the film.

Abstract: One or more aspects of the disclosure pertain to an article including a film disposed on a glass substrate, which may be strengthened, where the interface between the film and the glass substrate is modified, such that the article retains its average flexural strength, and the film retains key functional properties for its application. Some key functional properties of the film include optical, electrical and/or mechanical properties. The bridging of a crack from one of the film or the glass substrate into the other of the film or the glass substrate can be prevented by inserting a crack mitigating layer between the glass substrate and the film.

Abstract: One or more aspects of the disclosure pertain to an article including a film disposed on a glass substrate, which may be strengthened, where the interface between the film and the glass substrate is modified, such that the article has an improved average flexural strength, and the film retains key functional properties for its application. Some key functional properties of the film include optical, electrical and/or mechanical properties. In one or more embodiments, interface exhibits the effective adhesion energy is about less than about 4 J/m2. In some embodiments, the interface is modified by the inclusion of a crack mitigating layer between the glass substrate and the film.

Abstract: Delamination resistant glass containers with heat-tolerant coatings are disclosed. In one embodiment, a glass container may include a glass body having an interior surface, an exterior surface and a wall thickness extending from the exterior surface to the interior surface. At least the interior surface of the glass body is delamination resistant. The glass container may further include a heat-tolerant coating positioned on at least a portion of the exterior surface of the glass body. The heat-tolerant coating may be thermally stable at temperatures greater than or equal to 260° C. for 30 minutes.

Abstract: A system, such as a computer aided design (CAD) system, is configured to abstract at least a portion of an integrated circuit (IC) design provided thereto. The system selects two signals of the IC and determines the respective sub-circuits ending at each of the signals, excluding the other sub-circuit when two sub-circuits intersect. It then identifies an intersection of the two sub-circuits and therefore establishes an abstraction therefrom. The abstraction replaces the circuit for verification purposes of the IC design. The process can repeat as may be necessary or until no two signals have sub-circuits that intersect. The process described for two signals is equally applicable to a plurality of signals for which the intersection is defined as the intersection of all the sub-circuits defined by the plurality signals. The abstraction allows for effective verification of portions of ICs as may be necessary.

Abstract: Delamination resistant glass containers with heat-tolerant coatings are disclosed. In one embodiment, a glass container may include a glass body having an interior surface, an exterior surface and a wall thickness extending from the exterior surface to the interior surface. At least the interior surface of the glass body is delamination resistant. The glass container may further include a heat-tolerant coating positioned on at least a portion of the exterior surface of the glass body. The heat-tolerant coating may be thermally stable at temperatures greater than or equal to 260° C. for 30 minutes.

Abstract: A parser can be configured to parse source code to generate code for dynamically generating structures at runtime. Any or all of the structure name, keys, and values can be defined dynamically (i.e. at runtime), rather than requiring declaration in the source code. Embodiments include a method in which a source file is parsed to identify an expression creating a dynamic structure with at least one key-value pair. The method can comprise generating a plurality of expressions for creating intermediate data structures which, at runtime, can cause the dynamic structure to be defined as set forth in the declarative expression. The dynamic structure may comprise one or more declared key-value pairs and/or may comprise one or more key-value pairs that are also dynamic.

Abstract: A parser can be configured to parse source code to generate code for dynamically generating structures at runtime. Any or all of the structure name, keys, and values can be defined dynamically (i.e. at runtime), rather than requiring declaration in the source code. Embodiments include a method in which a source file is parsed to identify an expression creating a dynamic structure with at least one key-value pair. The method can comprise generating a plurality of expressions for creating intermediate data structures which, at runtime, can cause the dynamic structure to be defined as set forth in the declarative expression. The dynamic structure may comprise one or more declared key-value pairs and/or may comprise one or more key-value pairs that are also dynamic.

Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to pseudogenes as diagnostic markers and clinical targets for prostate cancer.

Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to gene fusions as diagnostic markers and clinical targets for breast cancer.

Abstract: Recurrent gene fusions in prostate cancer of androgen regulated genes or housekeeping genes and ETS family member genes are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.

Abstract: This invention pertains to a method for producing thermally stable multi-layer coatings and the coatings produced therefrom. The multi-layer coating is comprised of a first coating produced from hydrogen silsesquioxane having a thickness of 1.25 to 2.25 &mgr;m and a second coating comprising silicon dioxide having a thickness of at least 100 nm. The method for producing the first coating comprises applying a fillerless hydrogen silsesquioxane resin composition onto a substrate and thereafter heating the hydrogen silsesquioxane resin at a temperature of 150° C. to 500° C. for a sufficient period of time to produce a crack-free coating having a thickness of 1.25 &mgr;m to 2.25 &mgr;m. The second coating is produced by depositing, preferably by PECVD, silicon dioxide over the first coating at a thickness of at least 100 nm.

Abstract: This invention pertains to a method for producing crack-free, insoluble, greater than 1.25 .mu.m thick coatings from hydrogen silsesquioxane resin compositions. The method for producing the coating comprises applying a fillerless hydrogen silsesquioxane resin composition onto a substrate and thereafter heating the hydrogen silsesquioxane resin at a temperature of less than 500.degree. C. for a controlled period of time to produce the crack-free coating having a thickness of greater than 1.25 .mu.m. The resins may be cured in an inert or oxygen containing environment.

Abstract: This invention pertains to a method for producing crack-free, insoluble, greater than 1.25 .mu.m thick coatings from hydrogen silsesquioxane resin compositions. The method for producing the coating comprises applying a fillerless hydrogen silsesquioxane resin composition onto a substrate and thereafter heating the hydrogen silsesquioxane resin at a temperature of less than 500.degree. C. for a controlled period of time to produce the crack-free coating having a thickness of greater than 1.25 .mu.m. The resins may be cured in an inert or oxygen containing environment.