Patents by Inventor Chandra Prakash

Chandra Prakash has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090098205
    Abstract: The present invention provides a pH sensitive nanoparticulate delivery system for the administration of peptide hormones and drugs. In particular it provides a pH sensitive nanoparticulate for oral insulin administration. The nanoparticles developed by this process are fatty acid nanoparticles and a polymer is used as a stabilizer and also to incorporate pH sensitivity so that these particles shrink in the gastric acidic pH thereby protecting the incorporated insulin. These particles being also hydrophobic in nature and by virtue of their small size get absorbed through the intestinal cell wall and Peyer's patches. These nanoparticles are novel and unique in the sense that polymer content is only 0.03-0.06 g/g product and the polymer is hydrophilic in nature.
    Type: Application
    Filed: December 30, 2005
    Publication date: April 16, 2009
    Inventors: Chandra Prakash Sharma, Ramesan Rekha Mannemcherril
  • Patent number: 7390661
    Abstract: A bidirectional module for activation of gene expression and regulation of transcription in both directions is disclosed. The bidirectional module comprises multiple cis regulatory DNA sequence elements, strategically arranged to give a ‘Transcription Activating Module’ that achieves high level expression from a ‘Transcription Initiation Module’. The latter functions like a minimal promoter. The former activates transcription simultaneously in both the directions from the latter and also responds to several transcription inducing, external stimuli in both the directions. Since it is an artificially designed bidirectional transcription module, it has no equivalent DNA sequence in plant genome. This reduces the chances of the genes from being silenced by homology based mechanisms. A bidirectional promoter module as this, can therefore be used to develop efficient vectors for genetic engineering in plants.
    Type: Grant
    Filed: October 3, 2006
    Date of Patent: June 24, 2008
    Assignee: Council of Scientific and Industrial Research
    Inventors: Rakesh Tuli, Sawant Samir Vishwanath, Chandra Prakash Chaturvedi, Kanti Kiran, Rajesh Mehrotra
  • Patent number: 7235652
    Abstract: A bidirectional module for activation of gene expression and regulation of transcription in both directions is disclosed. The bidirectional module comprises multiple cis regulatory DNA sequence elements, strategically arranged to give a ‘Transcription Activating Module’ that achieves high level expression from a ‘Transcription Initiation Module’. The latter functions like a minimal promoter. The former activates transcription simultaneously in both the directions from the latter and also responds to several transcription inducing, external stimuli in both the directions. Since it is an artificially designed bidirectional transcription module, it has no equivalent DNA sequence in plant genome. This reduces the chances of the genes from being silenced by homology based mechanisms. A bidirectional promoter module as this, can therefore be used to develop efficient vectors for genetic engineering in plants.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: June 26, 2007
    Assignee: Council of Scientific and Industrial Research
    Inventors: Rakesh Tuli, Sawant Samir Vishwanath, Chandra Prakash Chaturvedi, Kanti Kiran, Rajesh Mehrotra
  • Publication number: 20070072885
    Abstract: The invention relates to substantially pure compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, R5, and X are as defined herein, and wherein the compound of formula 1 optionally further comprises a hydroxy substituent, an O-glucuronic acid, or an N?>O (N-oxide) moiety. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders that contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
    Type: Application
    Filed: June 5, 2006
    Publication date: March 29, 2007
    Inventors: Samit Bhattacharya, Chandra Prakash
  • Publication number: 20060287336
    Abstract: This invention relates to pharmaceutical compositions containing S-methyl-dihydro-ziprasidone and to the use of such compound and its pharmaceutically acceptable salts for the treatment of psychiatric and ocular disorders. More specifically, it relates to the use of such compound and its pharmaceutically acceptable salts for the treatment of a disorder or condition selected from: schizophrenia, anxiety disorders such as generalized anxiety disorder, panic disorder, posttraumatic stress disorder and phobias (e.g., social phobia, agoraphobia etc.
    Type: Application
    Filed: June 4, 2001
    Publication date: December 21, 2006
    Inventors: Chandra Prakash, Terese Smolarek
  • Publication number: 20050268535
    Abstract: Disclosed is a biodiesel fuel additive composition which accelerates combustion phenomenon, reduces ignition delay, and improves Cetane number, thereby lowering particulate emissions, and improving fuel economy in diesel engines.
    Type: Application
    Filed: June 2, 2004
    Publication date: December 8, 2005
    Applicant: POLAR MOLECULAR CORPORATION
    Inventors: Otis Nelson, Mark Nelson, A. Nelson, Chandra Prakash, Gilbert Chapelet
  • Publication number: 20050268531
    Abstract: Disclosed is an alcohol containing motor fuel additive composition which synergistically interacts with the alcohol additive to reduce fuel intake system deposit formation and/or combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
    Type: Application
    Filed: June 2, 2004
    Publication date: December 8, 2005
    Applicant: POLAR MOLECULAR CORPORATION
    Inventors: Otis Nelson, Mark Nelson, A. Nelson, Chandra Prakash, Gilbert Chapelet
  • Publication number: 20050268537
    Abstract: Disclosed is a ferrocene containing motor fuel additive composition which synergistically combines the octane enhancing capabilities of ferrocene with the benefits of a special additive package to reduce both fuel intake system deposit formation and combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
    Type: Application
    Filed: June 2, 2004
    Publication date: December 8, 2005
    Applicant: POLAR MOLECULAR CORPORATION
    Inventors: Otis Nelson, Mark Nelson, A. Nelson, Chandra Prakash, Gilbert Chapelet
  • Publication number: 20050268533
    Abstract: Disclosed is an ether containing motor fuel additive composition which synergistically interacts with the ether additive to reduce fuel intake system deposit formation and/or combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
    Type: Application
    Filed: June 2, 2004
    Publication date: December 8, 2005
    Applicant: POLAR MOLECULAR CORPORATION
    Inventors: Otis Nelson, Mark Nelson, A. Nelson, Chandra Prakash, Gilbert Chapelet
  • Publication number: 20050268534
    Abstract: Disclosed is a leaded motor fuel additive composition which synergistically interacts with the alkyl lead additive to reduce both fuel intake system deposit formation and combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
    Type: Application
    Filed: June 2, 2004
    Publication date: December 8, 2005
    Applicant: POLAR MOLECULAR CORPORATION
    Inventors: Otis Nelson, Mark Nelson, A. Nelson, Chandra Prakash, Gilbert Chapelet
  • Publication number: 20050268536
    Abstract: Disclosed is a diesel fuel additive composition which accelerates combustion phenomenon, reduces ignition delay, and improves Cetane number, thereby lowering particulate emissions, and improving fuel economy in diesel engines.
    Type: Application
    Filed: June 2, 2004
    Publication date: December 8, 2005
    Applicant: POLAR MOLECULAR CORPORATION
    Inventors: Otis Nelson, Mark Nelson, A. Nelson, Chandra Prakash, Gilbert Chapelet
  • Publication number: 20050268532
    Abstract: Disclosed is a MMT containing motor fuel additive composition which synergistically combines the octane enhancing capabilities of MMT with the benefits of a special additive package to reduce both fuel intake system deposit formation and combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
    Type: Application
    Filed: June 2, 2004
    Publication date: December 8, 2005
    Applicant: POLAR MOLECULAR CORPORATION
    Inventors: Otis Nelson, Mark Nelson, A. Nelson, Chandra Prakash, Gilbert Chapelet
  • Publication number: 20050256177
    Abstract: The invention relates to compounds of the formula 1 wherein X1, X2 and X3 independently is a halogen; p is an integer from 1 to 3; and R is —COOH, OR1 wherein R1 is a substituted isothiazole ring, or SR2 wherein R2 is (CH2)qC(COOH)(NHC(O)R3) wherein q is an integer from 0 to 3, and R3 is (C1-C4)alkyl; and to pharmaceutically acceptable salts, prodrugs and solvates thereof. The invention also relates to methods of treating a hyperproliferative disorder in a mammal by administering the compounds of formula 1 and to pharmaceutical compositions containing the compounds of formula 1.
    Type: Application
    Filed: May 16, 2005
    Publication date: November 17, 2005
    Inventors: Matthew Marx, Chandra Prakash, Zhuang Miao
  • Patent number: 6852863
    Abstract: The present invention relates to metabolites of (3-{[4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid.
    Type: Grant
    Filed: January 29, 2003
    Date of Patent: February 8, 2005
    Assignee: Pfizer Inc.
    Inventors: Kimberly O. Cameron, Kim A. Johnson, Bruce A. Lefker, Chandra A. Prakash
  • Publication number: 20030216445
    Abstract: The present invention relates to metabolites of (3-{[4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid.
    Type: Application
    Filed: January 29, 2003
    Publication date: November 20, 2003
    Inventors: Kimberly O. Cameron, Kim A. Johnson, Bruce A. Lefker, Chandra A. Prakash
  • Patent number: 6455572
    Abstract: This invention relates to compounds that are mammalian metabolites of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol. The compounds of the invention can be used as standards for analytical assays or as intermediates for the further chemical synthesis or biosynthesis of chemical entities. The invention also relates to pharmaceutical compositions for the treatment of disease and methods of treating disease.
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: September 24, 2002
    Assignee: Pfizer Inc.
    Inventors: Wesley W. Day, Kim A. Johnson, Chandra A. Prakash, James F. Eggler
  • Publication number: 20020042443
    Abstract: This invention relates to compounds that are mammalian metabolites of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol. The compounds of the invention can be used as standards for analytical assays or as intermediates for the further chemical synthesis or biosynthesis of chemical entities. The invention also relates to pharmaceutical compositions for the treatment of disease and methods of treating disease.
    Type: Application
    Filed: April 4, 2001
    Publication date: April 11, 2002
    Inventors: Wesley W. Day, Kim A. Johnson, Chandra A. Prakash, James F. Eggler
  • Patent number: RE39419
    Abstract: This invention relates to compounds that are mammalian metabolites of (?)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol. The compounds of the invention can be used as standards for analytical assays or as intermediates for the further chemical synthesis or biosynthesis of chemical entities. The invention also relates to pharmaceutical compositions for the treatment of disease and methods of treating disease.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: December 5, 2006
    Assignee: Pfizer Inc.
    Inventors: Wesley W. Day, Kim A. Johnson, Chandra A. Prakash, James F. Eggler