Patents by Inventor Chang-Guo Zhan

Chang-Guo Zhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220153805
    Abstract: Disclosed herein are polypeptide molecules having Prostate apoptosis response-4 (Par-4) pro-apoptotic activity in cancer cells and enhanced biological half-life, and related methods. Specifically, the disclosure provides a composition comprising Par-4 polypeptide fusion protein, and a method of inducing apoptosis in a cancer cell using the composition, wherein the cancer cell is metastatic.
    Type: Application
    Filed: April 10, 2020
    Publication date: May 19, 2022
    Inventors: Chang-Guo Zhan, Fang Zheng, Vivek M. Rangnekar, Kyungbo Kim
  • Patent number: 11325901
    Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: May 10, 2022
    Assignee: University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Fang Zheng, Kai Ding, Ziyuan Zhou
  • Publication number: 20220081432
    Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.
    Type: Application
    Filed: November 30, 2021
    Publication date: March 17, 2022
    Inventors: Chang-Guo Zhan, Fang Zheng, Kai Ding, Ziyuan Zhou
  • Publication number: 20220031709
    Abstract: Disclosed methods of inhibiting microsomal prostaglandin E2 (PGE2) synthase-1 (mPGES-1) make use of ceftriaxone, aztreonam, cefotetan, pharmaceutically-acceptable salts thereof, and combinations thereof.
    Type: Application
    Filed: August 3, 2021
    Publication date: February 3, 2022
    Inventors: Chang-Guo Zhan, Fang Zheng, Shuo Zhou, Ziyuan Zhou
  • Patent number: 11220497
    Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: January 11, 2022
    Assignee: University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Fang Zheng, Kai Ding, Ziyuan Zhou
  • Publication number: 20210380721
    Abstract: Compositions and methods are provided for use in binding opioids, such as 6-MAM, morphine, heroin, hydrocodone, oxycodone, meperidine, and fentanyl, while avoiding binding to OUD treatment agents, such as naloxone and naltrexone. Methods are also provided for use in a systematic structure-based virtual screening and design approach for identification of such antibodies. Methods are also provided for use in treating OUD. Methods are also provided for use in detecting an opioid in a sample.
    Type: Application
    Filed: June 1, 2021
    Publication date: December 9, 2021
    Inventors: Chang-Guo Zhan, Fang Zheng, Chunhui Zhang
  • Patent number: 11123341
    Abstract: A method of treating opioid use disorder involves administering a selective butyrylcholinesterase (BChE) inhibitor.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: September 21, 2021
    Assignee: University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Fang Zheng
  • Patent number: 11103509
    Abstract: A method of treating pain is disclosed, which involves administering an effective amount of lapatinib or a pharmaceutically-acceptable salt thereof to a subject in need of treatment for pain.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: August 31, 2021
    Assignee: University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Fang Zheng, Shuo Zhou, Ziyuan Zhou
  • Patent number: 11098296
    Abstract: Provided are mutant cocaine esterase polypeptides and PEGylated formulations thereof.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: August 24, 2021
    Assignees: The Trustees of Columbia University in the City of New York, University of Kentucky Research Foundation
    Inventors: Donald Landry, Chang-Guo Zhan
  • Publication number: 20210189359
    Abstract: The presently-disclosed subject matter describes fusion proteins comprising butyrylcholinesterase (BChE) having an improved production yield and biological half-life and nucleotides encoding the same.
    Type: Application
    Filed: December 21, 2020
    Publication date: June 24, 2021
    Inventors: Chang-Guo Zhan, Fang Zheng, Xiabin Chen
  • Publication number: 20200368224
    Abstract: A method of treating opioid use disorder involves administering a selective butyrylcholinesterase (BChE) inhibitor.
    Type: Application
    Filed: May 26, 2020
    Publication date: November 26, 2020
    Inventors: Chang-Guo Zhan, Fang Zheng
  • Patent number: 10772940
    Abstract: The presently-disclosed subject matter includes isolated polypeptides that comprise a butyrylcholinestrase (BChE) polypeptide and a second polypeptide. The BChE polypeptide as well as the second polypeptide can be variants and/or fragments thereof. The presently-disclosed subject matter also includes a pharmaceutical composition that comprises the present isolated polypeptide and a suitable pharmaceutical carrier. Further still, methods are provided for treating cocaine-induced conditions, and comprise administering the isolated polypeptide and/or pharmaceutical compositions thereof to an individual.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: September 15, 2020
    Assignee: University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Fang Zheng, Hsin-Hsiung Tai, Xiabin Chen, Liu Xue, Shurong Hou
  • Publication number: 20200231583
    Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.
    Type: Application
    Filed: June 28, 2017
    Publication date: July 23, 2020
    Inventors: Chang-Guo Zhan, Fang Zheng, Kai Ding, Ziyuan Zhou
  • Publication number: 20200138818
    Abstract: A method of treating pain is disclosed, which involves administering an effective amount of lapatinib or a pharmaceutically-acceptable salt thereof to a subject in need of treatment for pain.
    Type: Application
    Filed: November 6, 2019
    Publication date: May 7, 2020
    Inventors: Chang-Guo Zhan, Fang Zheng, Shuo Zhou, Ziyuan Zhou
  • Publication number: 20190352625
    Abstract: Provided are mutant cocaine esterase polypeptides and PEGylated formulations thereof.
    Type: Application
    Filed: December 21, 2018
    Publication date: November 21, 2019
    Inventors: Donald Landry, Chang-Guo Zhan
  • Patent number: 10160960
    Abstract: Provided are mutant cocaine esterase polypeptides and PEGylated formulations thereof.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: December 25, 2018
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Donald Landry, Chang-Guo Zhan
  • Patent number: 9879240
    Abstract: The Bacterial cocaine esterase (CocE) mutants disclosed herein each have enhanced catalytic efficiency for (?)-cocaine, as compared to CocE mutants in the prior art, including CocE mutant E172-173. The presently-disclosed subject matter further includes a pharmaceutical composition including a mutant of bacterial cocaine hydrolase, as described herein, and a suitable pharmaceutical carrier. The presently-disclosed subject matter further includes a method of treating a cocaine-induced condition comprising administering to an individual an effective amount of a mutant of bacterial cocaine hydrolase variant, as disclosed herein, to accelerate cocaine metabolism and produce biologically inactive metabolites.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: January 30, 2018
    Assignee: University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Fang Zheng, Lei Fang
  • Patent number: 9586946
    Abstract: Compounds useful for inhibiting the immunoproteasome have the formula of Methods and compounds for inhibiting the immunoproteasome, particularly, immunoproteasome inhibitors with non-peptide scaffolds, are described.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: March 7, 2017
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Chang-Guo Zhan, Kyung Bo Kim, Vinod Kasam, Na-Re Lee
  • Publication number: 20160332998
    Abstract: Compounds useful for inhibiting the immunoproteasome have the formula of Methods and compounds for inhibiting the immunoproteasome, particularly, immunoproteasome inhibitors with non-peptide scaffolds, are described.
    Type: Application
    Filed: May 16, 2016
    Publication date: November 17, 2016
    Inventors: Chang-Guo Zhan, Kyung Bo Kim, Vinod Kasam, Na-Re Lee
  • Patent number: 9493439
    Abstract: Compounds of formula (I) are useful for inhibiting a proteasome in a cell. Compounds, pharmaceutical compositions and methods of use are provided herein.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: November 15, 2016
    Assignee: University of Kentucky Research Foundation
    Inventors: Kyung-Bo Kim, Vinod Kasam, Wooin Lee, Dong-Eun Kim, Zach Miller, Chang-Guo Zhan, Do-Min Lee