Abstract: A sound absorption device and a method of manufacturing the same are provided. The sound absorption device includes a sound absorbing panel including first elements, second elements, third elements, and fourth elements arranged in different directions, wherein a cross-section of at least one of the first through fourth elements has a distorted circular shape, a distorted polygonal shape, or a distorted elliptical shape.

Abstract: An integrated circuit (IC) chip includes a plurality of interlayer channels; at least one data pad; an identification (ID) generation circuit suitable for generating a chip ID signal by decoding a command/address signal; a first transmission circuit suitable for transferring a plurality of internal data pieces to a transmission path by aligning a plurality of interlayer data pieces respectively transferred from the plurality of interlayer channels according to a plurality of strobe signals while selectively inverting the plurality of interlayer data pieces according to the chip ID signal; and a second transmission circuit suitable for transferring the plurality of internal data pieces from the transmission path to the at least one data pad.

Abstract: A duty correction device includes a clock generation circuit, first and second correction pulse generation circuits, and a duty correction circuit. The clock generation circuit generates first to third divided clock signals, each having a phase offset from a reference clock signal. The first correction pulse generation circuit generates a first correction pulse by detecting a phase difference between a delayed clock signal and the first and second divided clock signals. The second correction pulse generation circuit generates a second correction pulse by detecting a phase difference between the second and third divided clock signals. The duty correction circuit checks whether the first and second correction pulses are generated at a preset logic level of the reference clock signal, and reflects the first or second correction pulses in a duty correction operation for the reference clock signal according to a result of the check.

Abstract: The present invention relates to polyethylene glycol derivatives and use thereof.

Abstract: A semiconductor device comprises: a first or a second path configured to transmit a first signal which swings between a ground level and a first level, a third path configured to transmit a second signal which swings between the ground level and a second level lower than the first level, a transmitter configured to output received the first signal through the first or second path as the second signal to the third path, and initialize in response to an enable signal, and a receiver configured to output received the second signal through the third path as the first signal through the first or second path, determine level of the second signal through a reference level that is regulated according to a fed-back level of an output terminal thereof, and initialize in response to the enable signal.

Abstract: A sound absorption structure and a method of manufacturing the same are provided. The sound absorption structure includes a first sound absorption layer comprising first elements of which longitudinal directions are misaligned in a thickness direction of the sound absorption structure, the first sound absorption layer having a first internal filling density and absorbing sound waves of a first reactance frequency; and a second sound absorption layer disposed on the first sound absorption layer, having a second internal filling density different from the first internal filling density, and absorbing sound waves of a second reactance frequency different from the first reactance frequency.

Abstract: A physiologically active polypeptide-immunoglobulin Fc fragment conjugate and a method for making the conjugate are disclosed. The conjugate contains a physiologically active polypeptide linked via a non-peptidyl linker to an immunoglobulin Fc fragment having an FcRn-binding region and maintains the intrinsic binding affinity of the immunoglobulin Fc fragment. A method of maintaining the intrinsic binding affinity of the conjugate for FcRn, and a composition containing the conjugate, which maintains the intrinsic binding affinity of the immunoglobulin Fc fragment for FcRn are also disclosed.

Abstract: Disclosed is a method of managing data by an electronic apparatus, the method including identifying catalog data related to an item, generating target data corresponding to one or more target servers based on the catalog data, generating feed data corresponding to the one or more target servers at intervals of a preset period based on the target data, and transmitting the generated feed data to a corresponding target server.

Abstract: A method for managing item feed information according to example embodiments may include at least one of generating source information for an advertisement feed of items based on item information of a service related to the electronic apparatus, acquiring setting information for feed generation, generating feed information corresponding to at least one publisher by processing the generated source information based on the setting information, and providing the generated feed information to a server of the at least one publisher.

Abstract: A method for preparing a conjugate of a physiologically active polypeptide and a non-peptide polymer by linking physiologically active polypeptide with non-peptide polymer through a covalent bond using an organic solvent is provided. A method for preparing a physiologically active polypeptide complex by linking the conjugate with a carrier is provided. The complex shows improved in vivo duration and stability of the physiologically active polypeptide. The method can prepare the conjugate at a lower production cost, and the resulting conjugate shows an extension of in vivo activity at a relatively high level and significantly increase in the blood half-life.

Abstract: Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.

Abstract: Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex prepared by the present invention may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.

Abstract: A triple agonist having activities to all of glucagon, GLP-1, and GIP receptors is disclosed. Uses of the triple agonist are disclosed.

Abstract: A a triple agonist having activities to all of glucagon, GLP-1, and GIP receptors is disclosed. Uses of the triple agonist are disclosed.

Abstract: A method for increasing serum half-life of a protein or peptide and decreasing immunogenicity thereof is disclosed. The method includes site-specifically binding a carrier to a protein or peptide. A protein or peptide produced by the method and the uses thereof are disclosed. The conjugate of the physiologically active protein or peptide can significantly decrease immunogenicity in the human body and thus reduce antibody production rate against the protein or peptide. Therefore, the present conjugate has advantages in that a phenomenon of reduced clinical effects of the physiologically active protein or peptide is low, and it can be effectively used in the development of long-acting formulations having a high safety against the immune response.

Abstract: The present application relates to a method for selecting an injection-molded article and a method for manufacturing an injection-molded article. An injection-molded article having excellent crack stability can be produced using the material selected using the described selection method without having to manufacture test articles through injection molding.

Abstract: The present invention relates to a microstructure including a biocompatible polymer or an adhesive and to a method for manufacturing the same. The present inventors optimized the aspect ratio according to the type of each microstructure, thereby ensuring the optimal tip angle and the diameter range for skin penetration. Especially, the B-type to D-type microstructures of the present invention minimize the penetration resistance due to skin elasticity at the time of skin attachment, thereby increasing the penetration rate of the structures (60% or higher) and the absorption rate of useful ingredients into the skin. In addition, the D-type microstructure of the present invention maximizes the mechanical strength of the structure by applying a triple structure, and thus can easily penetrate the skin. When the plurality of microstructures are arranged in a hexagonal arrangement type, a uniform pressure can be transmitted to the whole microstructures on the skin.

Abstract: The present invention relates to an extrusion die and a method for extruding a sheet using the same, and according to one aspect of the present invention, there is provided an extrusion die comprising a storage part configured to hold a raw material, the storage part defining a first width, a pressure part configured to move the raw material through the storage part, a first die defining a second width less than the first width, such that a flow width of the raw material becomes narrower, a second die in fluid communication with the first die, the second die defining a width that increases from the second width to a third width, such that the flow width of the raw material passing through the first die becomes wider and a flow thickness becomes smaller, and a heating part configured to heat the raw material passing through the second die.

Abstract: The present invention relates to a novel peptide of a glucagon derivative and a composition for preventing or treating obesity comprising the peptide as an active ingredient. The glucagon derivative according to the present invention shows a more excellent activating effect with regard to both glucagon-like peptide-1 receptors and glucagon receptors compared to native glucagon, and thus can be widely used as an effective agent for treating obesity.

Abstract: The present invention relates to a novel peptide of a glucagon derivative and a composition for preventing or treating obesity comprising the peptide as an active ingredient. The glucagon derivative according to the present invention shows a more excellent activating effect with regard to both glucagon-like peptide-1 receptors and glucagon receptors compared to native glucagon, and thus can be widely used as an effective agent for treating obesity.