Abstract: In one aspect, a calibration system for use in a mass spectrometer having an open port interface (OPI) for receiving a sample for mass analysis is disclosed, which includes a fluidic junction having a first inlet in fluid communication with a first reservoir, which is configured for storing a calibration liquid, and a second inlet in fluid communication with a second reservoir, which is configured for storing a transport liquid. The fluidic junction can further include an outlet in fluid communication with the first and second inlets such that any of the calibration liquid and the transport liquid can exit the fluidic junction via said outlet.

Abstract: A method of forming a semiconductor device includes the following operations. A substrate is provided with a device and an insulating layer disposed over the device. A silicon-containing heterocyclic compound precursor and a first oxygen-containing compound precursor are introduced to the substrate, so as to form a zeroth dielectric layer on the insulating layer. A zeroth metal layer is formed in the zeroth dielectric layer. A silicon-containing linear compound precursor and a second oxygen-containing compound precursor are introduced to the substrate to form a first dielectric layer on the zeroth dielectric layer. A first metal layer is formed in the first dielectric layer.

Abstract: An embodiment of this application provides a method and apparatus for testing control software, and a computer-readable storage medium to reduce the time consumed in the simulation-based debugging and enhance efficiency. The method may include obtaining test information of a plurality of fault signals; and injecting, based on the test information of the plurality of fault signals, the plurality of fault signals into a simulation environment in sequence to obtain test results of the plurality of fault signals handled by the control software, where the simulation environment may be a simulation environment of a control object of the control software.

Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings. MS-based systems and methods are provided in which the flow of solvent into an open port sampling probe fluidly coupled to an ion source can be selectively stopped during the addition of one or more reagents into the drained open end of the sampling probe. Upon re-initiating the flow of solvent, the reagents and/or the reaction products can be delivered to the ion source. In one aspect, a method for chemical analysis is provided, the method comprising directing a flow of a first solvent from a solvent conduit to an ion source via a sampling space of a sampling probe, wherein the sampling space is at least partially defined by an open end of the sampling probe.

Abstract: The present disclosure provides an early warning method, apparatus, and system for a nitrogen concentration in industrialized aquaponic circulating water. The early warning method includes: obtaining video data of a sensitive fish farming container, where the video data includes a monitored movement behavior of a sensitive fish in the sensitive fish farming container, and the sensitive fish farming container is in communication with a farming pond of an aquaponic system; processing the video data using an object detection model and obtaining a behavior activity of the sensitive fish according to a processing result; processing the behavior activity using a neural network model to obtain a nitrogen concentration grade of the farming pond of the aquaponic system; and determining whether to send nitrogen concentration early warning information based on the nitrogen concentration grade.

Abstract: A semiconductor arrangement and method of forming the same are described. A semiconductor arrangement includes a first gate structure on a first side of an active area and a second gate structure on a second side of the active area, where the first gate structure and the second gate structure share the active area. A method of forming the semiconductor arrangement includes forming a deep implant of the active area before forming the first gate structure, and then forming a shallow implant of the active area. Forming the deep implant prior to forming the first gate structure alleviates the need for an etching process that degrades the first gate structure. The first gate structure thus has a desired configuration and is able to be formed closer to other gate structures to enhance device density.

Abstract: A method of processing a sample plate containing a plurality of samples includes aspirating simultaneously, from the sample plate, a first sample droplet from a first sample of the plurality of samples with a first pipette and a second sample droplet from a second sample of the plurality of samples with a second pipette. The sample plate also includes dispensing sequentially, from the first pipette and the second pipette, the first sample drop and the second sample drop into an open port interface (OPI).

Abstract: In one aspect, a method of introducing a sample into an open port interface (OPI) of a mass spectrometer is disclosed, which includes mixing the sample with a solvent in which a matrix of an aqueous phase of the sample is immiscible and in which at least a target analyte, when present in the sample, is miscible so as to extract at least a portion of the target analyte into said at least one solvent, thereby generating a multi-phase liquid having said aqueous phase and one or more organic phases, wherein at least one of those organic phases contains at least a portion of the target analyte. In some embodiments, the method further calls for ejecting a plurality of droplets from at least one of the phases of the multi-phase liquid for introduction into the OPI of the mass spectrometer.

Abstract: Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) TFR1, and methods of use thereof.

Abstract: In one aspect, a method of assessing hydrophobicity of a target analyte is disclosed, which includes introducing a sin-gle-phase system containing a concentration of the target analyte into a mass spectrometer to acquire at least one mass signal associated with the target analyte, introducing a phase-separated system (e.g., a two-phase system) containing substantially the same concentration of the target analyte into the mass spectrometer to acquire at least one mass signal associated with said target analyte, and utilizing a ratio of the intensities of the mass signals to assess hydrophobicity of the target analyte.

Abstract: An arrow shooting device with an arrow chain driving structure is disclosed. The arrow shooting device includes a gun body having a gun chamber and a chain hole, an arrow chain is inserted into a side of the chain hole and exposed out of the other side of the chain hole, the chain driving assembly is disposed in the gun chamber and controlled by the driving assembly to move, the moving chain driving assembly drives the arrow chain to move between two end openings of the chain hole, the chain driving assembly includes a first slider and a second slider. The second slider has a driving block to engage the arrow chain, the driving assembly is operated to repeatedly drive the first slider and the second slider to control the driving block to push the arrow chain to move through the chain hole.

Abstract: A PD controller integrated circuit of a USB apparatus is disclosed, including a CC pad, a first switch, a second switch, a PD controller circuit, a high voltage sensing circuit, and a switch control circuit. The high voltage sensing circuit senses the CC pad. When a current voltage of the CC pad does not exceed a rated range, the first switch and the second switch connected in series between the CC pad and the PD controller circuit are turned on. When the current voltage exceeds the rated range, the first switch and the second switch are turned off, and the switch control circuit maintains a voltage of a common node between the first switch and the second switch at a reduced level lower than the current voltage.

Abstract: An efficient and robust high-speed neural networks for cell image classification is described herein. The neural networks for cell image classification utilize a difference between soft-max scores to determine if a cell is ambiguous or not. If the cell is ambiguous, then the class is classified in a pseudo class, and if the cell is not ambiguous, the cell is classified in the class corresponding to the highest class score. The neural networks for cell image classification enable a high speed, high accuracy and high recall implementation.

Abstract: A system for analyzing a sample includes a sample preparation sub-system for preparing at least one sample in a sample vessel and a magnetic bead storage sub-system. A sample intake sub-system receives the at least one sample. A mass spectrometer (MS) is communicatively coupled to the sample intake sub-system. A transfer sub-system includes a tool for moving the sample vessel from the sample preparation sub-system to the sample intake sub-system.

Abstract: A fixture for testing bending shifting of a flexible display module and a test method thereof are provided. The flexible display module includes a bending region and a first non-bending region and a second non-bending region located at two sides of the bending region, the flexible display module is bent through the bending region, and the first non-bending region or the second non-bending region has an under-screen opening; the fixture includes a first support plate and a second support plate rotatably connected, the first support plate is configured to be fixedly connected with the first non-bending region, and the second support plate is configured to be fixedly connected with the second non-bending region; the first support plate or the second support plate has a transparent region, and the transparent region is disposed for observation of shifting at the under-screen opening of the flexible display module in a bent state.

Abstract: Provided herein is a kit for isolation of platelet-rich plasma, comprising a first isolation tube and a second isolation tube. The first isolation tube comprises a first opening and a second opening, and the second isolation tube comprises a first portion, a second portion, and a filter, wherein the first portion has a third opening, the filter is disposed between the first portion and the second portion, the second opening has a diameter in a range of 1 to 5 mm and the filter has a pore size in a range of 1.5 to 4 ?m.

Abstract: Improvements in acoustically dispensed samples that are injected into an open port probe (OPP) are described. Apparatus and method are described that calibrate the volume dispensing determination and mechanisms in the acoustic dispenser to produce accurate and precise volumetric delivery.

Abstract: A method for automatically estimating cellularity in a digital pathology slide image includes: extracting patches of interest from the digital pathology slide image; operating on each patch using a trained first deep convolutional neural network (DCNN) to classify that patch as either normal, having an estimated cellularity of 0%, or suspect, having a cellularity roughly estimated to be greater than 0%; operating on each suspect patch using a second DCNN, trained using a deep ordinal regression model, to determine an estimated cellularity score for that suspect patch; and combining the estimated cellularity scores of the patches of interest to provide an estimated cellularity for the digital pathology slide image at a patch-by-patch level.

Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which an open port of a sampling probe for receiving a specimen may be exposed to washing solvent to wash the sampling probe while fluid within the sampling probe remains continuously flowing.

Abstract: A method includes obtaining first traveling information of a vehicle from a sensor associated with the vehicle, and determining, based on the first traveling information, first location information of the vehicle and a first intermediate variable that is used in the determining the first location information. The method also includes determining a target precision estimation model from a plurality of pre-trained precision estimation models based on the first traveling information and the first intermediate variable. The plurality of pre-trained precision estimation models are obtained by training a machine learning model based on a training sample set. The method also includes inputting the first location information and the first intermediate variable into the target precision estimation model to obtain second location information of the vehicle and a precision error of the first location information relative to the second location information.