Abstract: Certain embodiments pertain to laser-based Fourier ptychographic (LFP) imaging systems, angle direction devices used in the LFP imaging systems, optical switches used in the LFP imaging systems, and LFP imaging methods. The LFP systems include an angle direction device for directing laser light to a sample plane at a plurality of illumination angles at different sample times. The LFP systems also include an optical system and a light detector. The optical system receives light issuing from the sample being imaged and propagates and focuses the light to the light detector acquiring raw intensity images.

Abstract: Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods such as, for example, high NA Fourier ptychographic imaging systems and reflective-mode NA Fourier ptychographic imaging systems.

Abstract: Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods such as, for example, high NA Fourier ptychographic imaging systems and reflective-mode NA Fourier ptychographic imaging systems.

Abstract: Certain aspects pertain to aperture-scanning Fourier ptychographic imaging devices comprising an aperture scanner that can generate an aperture at different locations at an intermediate plane of an optical arrangement, and a detector that can acquire lower resolution intensity images for different aperture locations, and wherein a higher resolution complex image may be constructed by iteratively updating regions in Fourier space with the acquired lower resolution images.

Abstract: Aberration-corrected incoherent imaging methods and systems that can acquire a sequence of coherent images and an incoherent image of a specimen, implement an embedded pupil function recovery process in junction with Fourier ptychographic technique to construct an improved resolution image and pupil function of the imaging system using the sequence of coherent images, determine an optical transfer function based on the estimated pupil function, and remove the aberration from the incoherent image using a deconvolution process to generate an aberration-corrected incoherent image.

Abstract: A scanning projective lensless microscope device comprises a specimen surface, a scanning illumination source with a light element, a light detector outside the specimen surface, and a processor. The scanning illumination source scans the light element to a plurality of scanning locations to provide illumination to an object on the specimen surface. The light detector samples a sequence of sub-pixel shifted projection object images corresponding to the plurality of scanning locations. The processor constructs a high resolution image of the object based on the sequence of sub-pixel shifted projection images and a motion vector of the projections at a plane of interest.

Abstract: Certain aspects pertain to aperture-scanning Fourier ptychographic imaging devices comprising an aperture scanner that can generate an aperture at different locations at an intermediate plane of an optical arrangement, and a detector that can acquire lower resolution intensity images for different aperture locations, and wherein a higher resolution complex image may be constructed by iteratively updating regions in Fourier space with the acquired lower resolution images.

Abstract: Certain aspects pertain to multi-well systems, devices, and methods of Fourier ptychographic and fluorescence imaging.

Abstract: In one aspect an imaging system includes: an illumination system including an array of light sources; an optical system including one or more lens arrays, each of the lens arrays including an array of lenses, each of the lenses in each of the one or more lens arrays in alignment with a corresponding set of light sources of the array of light sources; an imaging system including an array of image sensors, each of the image sensors in alignment with a corresponding lens or set of lenses of the one or more lens arrays, each of the image sensors configured to acquire image data based on the light received from the corresponding lens or set of lenses; a plate receiver system capable of receiving a multi-well plate including an array of wells, the plate receiver system configured to align each of the wells with a corresponding one of the image sensors; and a controller configured to control the illumination of the light sources and the acquisition of image data by the image sensors, the controller further configure

Abstract: Certain aspects pertain to Fourier ptychographic tomographic systems and methods for acquiring a plurality of uniquely illuminated intensity measurements based on light passing through a thick sample from plane wave illumination at different angles and for constructing three-dimensional tomographic data of the thick sample by iteratively determining three-dimensional tomographic data in the Fourier domain that is self-consistent with the uniquely illuminated intensity measurements.

Abstract: Certain aspects pertain to epi-illumination Fourier ptychographic imaging systems and methods for high resolution imaging of thick samples.

Abstract: A method and apparatus for irradiating a scattering medium with increased resolution. The method includes transmitting EM radiation from an Electromagnetic (EM) radiation source to a target inside a scattering medium, wherein the target encodes the EM radiation with a variance structure to form encoded EM radiation; measuring, in a detector, transmitted EM radiation comprising at least a portion of the encoded EM radiation transmitted through and exiting the scattering medium; decoding the transmitted EM radiation, comprising EM fields, in a computer, comprising selecting one or more of the EM fields having the variance structure; and irradiating the scattering medium with time reversed EM radiation from a spatial light modulator (SLM), the time reversed EM radiation generated from time reversing the EM fields having the variance structure, thereby forming a focus of the time reversed EM radiation in the scattering medium with the increased resolution.

Abstract: Embodiments of the present invention relate to a high-resolution imaging device with wide field and extended focus comprising a beam generator for generating a plurality of nondiffracting beams and a scanning mechanism for moving the plurality of nondiffracting beams relative to the object to illuminate a volume of the object. The high-resolution imaging device also comprises surface element and a body having a light detector layer outside the surface element. The light detector layer has a light detector configured to measure light data associated with the plurality of nondiffracting beams illuminating the volume of the object. In some cases, the high-resolution imaging device also includes a lens inside of the light detector layer. The lens is configured to focus the light on the light detector surface.

Abstract: A light guided pixel having a guide layer and a light detector layer. The guide layer has a light guide. The light detector layer has a light detecting element that receives light channeled by the light guide. The light guide may include a filter for channeling emissions to the light detecting element.

Abstract: A device and method for performing fluorescence imaging with digitally time reversed ultrasound encoded light, using a source of ultrasound waves, a coherent light source, a digital optical phase conjugation (DOPC) device comprising a camera and a spatial light modulator (SLM), a detector of fluorescence, and one or more computers, to obtain an output that at least approximates an interaction between a complete time reversed field, of all of the encoded light's fields, and the scattering medium.

Abstract: Certain embodiments pertain to Multiplexed Fourier Ptychographic imaging systems and methods. In one example, the Multiplexed Fourier Ptychographic imaging system includes an LED array configured to illuminate a sequence of LED patterns for illuminating a sample being imaged. The system includes LED circuitry configured to independently control power to turn on multiple LEDs simultaneously in each LED pattern of the array. The system has a light detector that acquires a first set of lower resolution images of the sample each image acquired during exposure time during illumination by a unique LED pattern. The system uses the first set of lower resolution images to generate a second set of lower resolution images associated with each LED in the LED array and iteratively updates overlapping regions in the Fourier domain with the second set of lower resolution images to generate a higher resolution image.

Abstract: Spatial frequency swept interference (SFSI) illumination and imaging methods and devices that interfere two collimated coherent beams to generate an interference pattern of a plurality of illuminating sheets with sweeping spatial frequency.

Abstract: Certain aspects pertain to ptychographic imaging systems and methods with convex relaxation. In some aspects, a ptychographic imaging system with convex relaxation comprises one or more electromagnetic radiation sources, a digital radiation intensity detector, and a processor in communication with the digital radiation detector. The electromagnetic radiation provides coherent radiation to a specimen while the digital radiation intensity detector receives light transferred from the sample by diffractive optics and captures intensity distributions for a sequence of low resolution images having diversity. The processor generates a convex problem based on the sequence of low resolution images and optimizes the convex problem to reconstruct a high-resolution image of the specimen. In certain aspects, the convex problem is relaxed into a low-rank formulation.

Abstract: Certain aspects pertain to Fourier camera systems and methods. In one aspect, a Fourier camera comprises a first optical system, a second optical system, a variable aperture filter, and a light detector. The first optical system configured to receive illumination reflected from a curved sample surface. The variable aperture filter configured to move an aperture to a plurality of aperture locations in a Fourier plane, wherein the aperture filters light from the first optical system to the second optical system. The light detector configured to receive light from the second optical system, and configured to acquire a plurality of raw intensity images of the curved sample surface corresponding to the plurality of aperture locations, wherein the raw images are iteratively updated in overlapping regions in Fourier space to generate a focused, substantially uniform resolution image of the curved sample surface, and wherein the overlapping regions correspond to the plurality of aperture locations.

Abstract: A method for irradiating a scattering medium, including irradiating a scattering medium with radiation from a laser, to form scattered radiation having a scattered field; measuring a difference in the scattered field caused by motion of a moving target in or behind the scattering medium; forming a phase conjugate of the difference to form a phase conjugate field; and irradiating the scattering medium with the phase conjugate field formed using one or more radiation modulating elements. Thus we present that movement of objects can be used as a novel guide star in Digital Optical Phase Conjugation (DOPC). By time reversal of difference of scattering fields of a moving target, light can be focused through scattering media.