Abstract: Embodiments of the present invention relate to a method for computing depth sectioning of an object using a quantitative differential interference contrast device having a wavefront sensor with one or more structured apertures, a light detector and a transparent layer between the structured apertures and the light detector. The method comprises receiving light, by the light detector, through the one or more structured apertures. The method also measures the amplitude of an image wavefront, and measures the phase gradient in two orthogonal directions of the image wavefront based on the light. The method can then reconstruct the image wavefront using the amplitude and phase gradient. The method can then propagate the reconstructed wavefront to a first plane intersecting an object at a first depth. In one embodiment, the method propagates the reconstructed wavefront to additional planes and generates a three-dimensional image based on the propagated wavefronts.

Abstract: Embodiments of the present invention relate to a reflective focusing and transmissive projection device having a body, a set of reflective-focusing components and a light detector. The body has a surface layer with first and second surfaces, and a detecting layer outside the second surface. The set of reflective-focusing components is in the surface layer. Each reflective-focusing component has a contouring element and a curved reflective element conformed to the contouring element. The curved reflective element is configured to reflect light of a first type, transmit light of a second type and focus the light of the first type outside the first surface of the surface layer. The light detector is in the detecting layer, and is configured to receive light and generate light data associated with the received light. Also, the contouring element can be configured to focus the light of the second type on the light detector.

Abstract: A device and method for performing fluorescence imaging with digitally time reversed ultrasound encoded light, using a source of ultrasound waves, a coherent light source, a digital optical phase conjugation (DOPC) device comprising a camera and a spatial light modulator (SLM), a detector of fluorescence, and one or more computers, to obtain an output that at least approximates an interaction between a complete time reversed field, of all of the encoded light's fields, and the scattering medium.

Abstract: A device, including one or more Communication Physical Unclonable Function (CPUF) and key storage devices, the CPUF devices each comprising: a coherent Electromagnetic (EM) radiation source; a spatial light modulator (SLM) connected to the coherent EM radiation source; a volumetric scattering medium connected to the SLM; a detector connected to the volumetric scattering medium; and one or more processors or circuits connected to the detector and one or more processors or circuits connected to the SLM. A communication protocol is also provided.

Abstract: Embodiments of the present invention relate to a delayed emission detection device comprising a time-gated illumination source configured to provide excitation light to fluorophore during an excitation period and a light detector configured to receive emissions released from the fluorophore during a collection period after the excitation period.

Abstract: An optical phase processing system for a scattering medium. A first beam has a direction and a wavefront and the first beam is configured to enter a holographic recording medium. A scattering medium is illuminated by a signal beam generating at least one scattered beam. An interference pattern is recorded from the at least one scattered beam and the first beam. A second beam is generated in a direction opposite to the direction of the first beam, the second beam having a wavefront and a phase substantially opposite to a phase of the wavefront of the first beam, and the second beam is configured to enter the holographic recording medium. The second beam and the interference pattern interact to generate at least one reconstructed beam having a phase substantially opposite to a phase of the at least one scattered beam, and the at least one reconstructed beam is configured to be viewable through the scattering medium.

Abstract: Embodiments of the present invention relate to a wavefront sensor comprising a film and a photodetector. The film has one or more structured two dimensional apertures configured to convert a phase gradient of a wavefront into a measurable form. The photodetector is configured to receive the wavefront through the one or more 2D apertures and measure the phase gradient of the wavefront.

Abstract: A light microscope for imaging a sample containing one or more fluorescent agents, comprising a source for generating acoustic waves that are focused at a focus in the sample, wherein the acoustic waves frequency shift a frequency of light passing through the focus, thereby creating a frequency shifted light beam; at least one spatial light modulator (SLM) positioned to illuminate the sample with an output beam that is an optical phase conjugate of the frequency shifted light beam, wherein the output beam is a reflection of a first reference beam off one or more pixels of the SLM, and the pixels are for modulating the first reference beam to create the output beam; and a detector positioned to detect fluorescence generated by the output beam exciting the fluorescent agents at the focus in the sample, thereby imaging the sample.

Abstract: Embodiments of the present invention relate to a wavefront imaging sensor (WIS) comprising an aperture layer having an aperture, a light detector having a surface and a transparent layer between the aperture layer and the light detector. The light detector can receive a light projection at the surface from light passing through the aperture. The light detector can also separately measure amplitude and phase information of a wavefront at the aperture based on the received light projection. The transparent layer has a thickness designed to locate the surface of the light detector approximately at a self-focusing plane in a high Fresnel number regime to narrow the light projection.

Abstract: A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination source, and a photodetector to receive Young's interference from the illumination passing through the pair of two apertures. In addition, a surface wave assisted optofluidic microscope and method utilize an illumination source, a fluid channel having a layer with at least one aperture as a surface, and a photodetector that receives a signal based on the illumination passing through the aperture. The layer is corrugated (e.g., via fabrication) and parameters of the corrugation optimize the signal received on the photodetector.

Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code.

Abstract: Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique that may be used employs surface tension at a hydrophobic surface to passively pump the fluid sample through the fluid channel. Another technique uses electrodes to adjust the position of objects in the fluid channel. Another technique computationally adjusts the focal plane of an image wavefront measured using differential interference contrast (DIC) based on Young's interference by back propagating the image wavefront from the detection focal plane to a different focal plane. These techniques can be employed separately or in combination to improve the capabilities of OFM devices.

Abstract: A system, method, and apparatus provide the ability to reconstruct an image from an object. A hand-held image acquisition device is configured to acquire local image information from a physical object. A tracking system obtains displacement information for the hand-held acquisition device while the device is acquiring the local image information. An image reconstruction system computes the inverse of the displacement information and combines the inverse with the local image information to transform the local image information into a reconstructed local image information. A display device displays the reconstructed local image information.

Abstract: Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique which may be used eliminates the aperture layer covering the light detector layer. Other techniques retain the aperture layer, reversing the relative position of the light source and light detector such that light passes through the aperture layer before passing through the fluid channel to the light detector. Another technique adds an optical tweezer for controlling the movement of objects moving through the fluid channel. Another technique adds an optical fiber bundle to relay light from light transmissive regions to a remote light detector. Another technique adds two electrodes at ends of the fluid channel to generate an electrical field capable of moving objects through the fluid channel while suppressing rotation. These techniques can be employed separately or in combination to improve the capabilities of OFM devices.

Abstract: A Talbot-illuminated imaging system for focal plane tuning, the device comprising a Talbot element, a tunable illumination source, a scanning mechanism, a light detector, and a processor. The element generate san array of focused light spots at a focal plane. The tunable illumination source shifts the focal plane to a plane of interest by adjusting a wavelength of light incident the Talbot element. The scanning mechanism scans an object across an array of focused light spots in a scanning direction. The light detector determines time-varying light data associated with the array of focused light spots as the object scans across the array of light spots. The processor constructs an image of the object based on the time-varying data.

Abstract: A surface wave assisted system having an aperture layer with a surface and an aperture, and a plurality of grooves around the aperture. The plurality of grooves is configured to generate an optical transfer function at the aperture by inducing a surface wave for interfering with transmission of light of a range of spatial frequency.

Abstract: Talbot imaging systems comprising a Talbot element, a phase gradient generating device, a light detector, and a processor. The Talbot element repeats a Talbot image at a distance from the Talbot element. The phase gradient generating device scans the Talbot image at a plane at the distance from the Talbot element by incrementally changing a phase gradient of a light field incident the Talbot element. As the Talbot image is scanned, the light detector captures time varying data associated with light altered by an object located at the distance from the Talbot element. The processor reconstructs an image of the object based on the time-varying light data.

Abstract: A light guided pixel having a guide layer and a light detector layer. The guide layer has a light guide. The light detector layer has a light detecting element that receives light channeled by the light guide. The light guide may include a filter for channeling emissions to the light detecting element.

Abstract: An e-Petri dish comprising a transparent layer having a specimen surface and a light detector configured to sample a sequence of sub-pixel shifted projection images of a specimen located on the specimen surface. The sub-pixel shifted projection images associated with light from a plurality of illumination angles provided by an illumination source.

Abstract: A light-field pixel for detecting a wavefront, the light-field pixel comprises an aperture layer, a light detector layer, and a processor. The aperture layer has a non-conventional aperture and a non-conventional aperture. The non-conventional aperture has a higher gradient of transmission at normal incidence than the conventional aperture. The light detector is configured to measure a first intensity of light through the non-conventional aperture and a second intensity of light through the conventional aperture. The processor is configured to detect the wavefront based on the first intensity normalized by the second intensity.