Patents by Inventor Chao-Min Cheng

Chao-Min Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210115398
    Abstract: A corneal tissue culture system and a corneal tissue culture method for increasing corneal endothelial cell density, healing of damaged corneal endothelial cell, and stimulating corneal endothelial cell proliferation are disclosed. The corneal tissue culture system comprises a tissue culture medium and a tissue culture dish to reduce metabolic pressure and reduce corneal tissue edema.
    Type: Application
    Filed: June 26, 2020
    Publication date: April 22, 2021
    Inventors: Hung-Chi CHEN, Chao-Min CHENG, Chieh-Cheng HUANG, Yi-Jen HSUEH
  • Publication number: 20200080988
    Abstract: The present invention provides a detection device for body fluid separation, which comprises the plurality of bottles, the upper knob member having an upper outer casing and an upper inner casing sleeved within the upper outer casing, and the lower knob member having a lower outer casing and a lower inner casing sleeved within the lower outer casing. When the upper outer casing is tightly coupled to the upper inner casing or the lower outer casing is tightly coupled to the lower inner casing, the bottles do not communicate with each other. When the upper outer casing is separated from the upper inner casing or the lower outer casing is separated from the lower inner casing, the bottles communicate with each other. Accordingly, the detection result can be quickly determined by the detection device and detection method for body fluid separation.
    Type: Application
    Filed: February 4, 2019
    Publication date: March 12, 2020
    Inventors: Chao-Min CHENG, Yi-Tzu LEE
  • Patent number: 10422766
    Abstract: A manufacturing device and a manufacturing method of a test strip. The manufacturing device includes a fluid push module, a fluid flow module and a fluid output module. The fluid push module includes an actuator and a transmission unit. The transmission unit has at least a fluid delivery member. The fluid flow module includes a reagent storage unit and a reagent delivery unit. The reagent storage unit has at least one reagent storage chamber. The reagent delivery unit has at least one drain chamber, at least one first infusion line, at least a second infusion line and a plurality of check valves. The fluid output module includes a plurality of reagent outlets and a reagent output unit, and one end of each of the reagent outlets is configured with an inner recess. The reagent output unit has a plurality of channels corresponding to the reagent outlets.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: September 24, 2019
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventor: Chao-Min Cheng
  • Publication number: 20190099401
    Abstract: A method for protecting corneal endothelial cells from the impact caused by an eye surgery is disclosed. The ophthalmic composition is administered to a patient's eye continuously for at least five days before an eye surgery for reducing the impact to the corneal endothelial cells caused by the eye surgery. The ophthalmic composition comprises an ascorbic acid and a pharmaceutically acceptable ophthalmic carrier.
    Type: Application
    Filed: March 13, 2018
    Publication date: April 4, 2019
    Inventors: Hung-Chi CHEN, Hui-Kang MA, Chao-Min CHENG, Yi-Jen HSUEH
  • Publication number: 20180371522
    Abstract: The present invention provides a method for manufacturing a microbial detection device, microbial detection method, microbial detection kit and microbial detection device. The manufacturing method includes the following steps: defining a sampling portion and a reaction portion on a substrate. Fiber materials are disposed in the reaction portion and a surface of the reaction portion which contacts with the fiber materials comprises abundant hydroxyl groups. Reaction reagents are then added into the fiber materials. An acidic solution is applied to treat the fiber materials and the hydroxyl groups in the reaction portion.
    Type: Application
    Filed: September 4, 2018
    Publication date: December 27, 2018
    Inventors: Chen-Meng KUAN, Robert S. LANGER, Chao-Min CHENG
  • Patent number: 10106832
    Abstract: The present invention provides a method for manufacturing a microbial detection device, microbial detection method, microbial detection kit and microbial detection device. The manufacturing method includes the following steps: defining a sampling portion and a reaction portion on a substrate. Fiber materials are disposed in the reaction portion and a surface of the reaction portion which contacts with the fiber materials comprises abundant hydroxyl groups. Reaction reagents are then added into the fiber materials. An acidic solution is applied to treat the fiber materials and the hydroxyl groups in the reaction portion.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: October 23, 2018
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Chen-Meng Kuan, Robert S. Langer, Chao-Min Cheng
  • Publication number: 20180275087
    Abstract: A manufacturing device and a manufacturing method of a test strip. The manufacturing device includes a fluid push module, a fluid flow module and a fluid output module. The fluid push module includes an actuator and a transmission unit. The transmission unit has at least a fluid delivery member. The fluid flow module includes a reagent storage unit and a reagent delivery unit. The reagent storage unit has at least one reagent storage chamber. The reagent delivery unit has at least one drain chamber, at least one first infusion line, at least a second infusion line and a plurality of check valves. The fluid output module includes a plurality of reagent outlets and a reagent output unit, and one end of each of the reagent outlets is configured with an inner recess. The reagent output unit has a plurality of channels corresponding to the reagent outlets.
    Type: Application
    Filed: July 14, 2017
    Publication date: September 27, 2018
    Inventor: Chao-Min CHENG
  • Patent number: 10048259
    Abstract: A portable fluorescence detection system for a test unit comprises a housing, a light source module and a image capturing module. The housing has a receiving area for accommodating the test unit. The light source module is disposed in the housing and projecting light towards the receiving area. The image capturing module is disposed in the housing and receiving fluorescence light from the receiving area so as to capture an image. The above-mentioned system can be applied to the point-of-care testing.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: August 14, 2018
    Assignee: National Tsing Hua University
    Inventor: Chao-Min Cheng
  • Patent number: 9764303
    Abstract: A method for manufacturing a detection device includes dispensing a plurality of reagent droplets of a detection reagent to a fiber substrate by a dispensing unit, and absorbing the plurality of reagent droplets by the fiber substrate to form the detection device having at least one detection pore. The dispensing unit includes two plastic sheets and a water retention substrate, the water retention substrate contains the detection reagent, and one of the two plastic sheets has at least one opening.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: September 19, 2017
    Assignee: National Tsing Hua University
    Inventors: Shang-Chi Lin, Chun-Wei Lee, Shueh-Yao Chu, Chao-Min Cheng, Fan-Gang Tseng
  • Publication number: 20170254804
    Abstract: A portable fluorescence detection system for a test unit comprises a housing, a light source module and a image capturing module. The housing has a receiving area for accommodating the test unit. The light source module is disposed in the housing and projecting light towards the receiving area. The image capturing module is disposed in the housing and receiving fluorescence light from the receiving area so as to capture an image. The above-mentioned system can be applied to the point-of-care testing.
    Type: Application
    Filed: May 22, 2017
    Publication date: September 7, 2017
    Inventor: Chao-Min CHENG
  • Patent number: 9689869
    Abstract: A portable fluorescence analysis system comprises a fluorescence strip, a fluorescence excitation device and a mobile Internet device. The fluorescence strip comprises a fluorescence probe configured for detecting an analyte within a specimen. The fluorescence excitation device comprises a sleeve and an excitation light source module. The fluorescence strip is arranged at the one open end of the sleeve. The excitation light source module is arranged at the same opening side of the sleeve and configured for providing an excitation light to excite the fluorescence probe to generate fluorescence. The mobile Internet device comprises an image capturing module and configured for capturing a fluorescence image of the fluorescence strip via the other opening of the sleeve and analyzing fluorescence intensity of the fluorescence image to determine the content of the analyte. The above-mentioned system can be applied to the point of care testing.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: June 27, 2017
    Assignee: National Tsing Hua University
    Inventors: Shih-Jie Lo, Min-Wei Hung, Jer-Liang Yeh, Da-Jeng Yao, Chao-Min Cheng
  • Patent number: 9689854
    Abstract: A food safety detection device includes a xylem fiber substrate, which is configured with a sampling portion and a reaction portion. The reaction portion includes at least one chemical reagent. The sampling portion absorbs a test sample. The test sample moves on the xylem fiber substrate to the reaction portion and reacts with the chemical reagent. A manufacturing method for the food safety detection device is also disclosed. The food safety detection device is advantageous for easy operation, safety and rapid analysis.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: June 27, 2017
    Assignee: National Tsing Hua University
    Inventors: Chen-Meng Kuan, Roger L. York, Robert S. Langer, Chao-Min Cheng
  • Patent number: 9689865
    Abstract: The present invention provides a personal hygiene item. In simple terms, one of the main features of the present invention is to provide a low-cost personal hygiene item capable of providing a multi-component detection function. The personal hygiene item of the present invention mainly comprises a first material layer and a second material layer. The first material layer is made of hydrophobic material, and the second material layer is disposed thereon. Also, the second material layer comprises a discolored portion. In actual practice, a fluid under test contacts with the corresponding discolored portions via the hydrophobic layer of second material layer for a color changing reaction. Meanwhile, since the hydrophilic performance of the discolored portion is better than the hydrophilic performance of the hydrophilic layer, the back permeation of the fluid under test can herein be prevented.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: June 27, 2017
    Assignee: National Tsing Hua University
    Inventors: Chung-Yao Yang, Szu-Ting Lin, Jer-Liang Yeh, Chao-Min Cheng
  • Patent number: 9684003
    Abstract: Disclosed is a detection method, including steps of: providing an elongated carrier with a plurality of recognition substances fixed thereon; bringing a first end of the elongated carrier in contact with a liquid sample to permit the liquid sample to move towards an opposite second end along the elongated carrier, therewith a plurality of coloring elements in the liquid sample forming a colored band on the elongated carrier; and determining whether the liquid sample contains analytes based on the length of the colored band. Accordingly, the analytes can be detected by recognizing the agglutination based on the length of the colored band. Additionally, the present invention also provides a detection device and a detection kit for the aforementioned detection process.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: June 20, 2017
    Assignee: National Tsing Hua University
    Inventor: Chao-Min Cheng
  • Publication number: 20170122967
    Abstract: Disclosed is a detection method, including steps of: providing an elongated carrier with a plurality of recognition substances fixed thereon; bringing a first end of the elongated carrier in contact with a liquid sample to permit the liquid sample to move towards an opposite second end along the elongated carrier, therewith a plurality of coloring elements in the liquid sample forming a colored band on the elongated carrier; and determining whether the liquid sample contains analytes based on the length of the colored band. Accordingly, the analytes can be detected by recognizing the agglutination based on the length of the colored band. Additionally, the present invention also provides a detection device and a detection kit for the aforementioned detection process.
    Type: Application
    Filed: August 23, 2016
    Publication date: May 4, 2017
    Inventor: Chao-Min CHENG
  • Patent number: 9612203
    Abstract: A detection device includes a xylem fiber substrate configured with a sampling portion and a reaction portion. The reaction portion includes at least one enzyme reagent. The sampling portion absorbs a test sample. The test sample moves on the xylem fiber substrate to the reaction portion and reacts with the enzyme reagent. A manufacturing method for the detection device is also disclosed. The detection device is advantageous for easy operation, safety and rapid analysis.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: April 4, 2017
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Chen-Meng Kuan, Roger L. York, Robert S. Langer, Chao-Min Cheng
  • Publication number: 20170058311
    Abstract: The present invention provides a method for manufacturing a microbial detection device, microbial detection method, microbial detection kit and microbial detection device. The manufacturing method includes following steps: defining a sampling portion and a reaction portion on a substrate. Fiber materials are disposed in the reaction portion and a surface of the reaction portion which contacts with the fiber materials comprises abundant hydroxyl groups. Reaction reagents are then added into the fiber materials. An acidic solution is applied to treat the fiber materials and the hydroxyl groups in the reaction portion. The present invention is advantageous for easy operation, safety, and rapid analysis.
    Type: Application
    Filed: August 12, 2016
    Publication date: March 2, 2017
    Inventors: Chen-Meng KUAN, Robert S. LANGER, Chao-Min CHENG
  • Publication number: 20160375436
    Abstract: A detection device includes a carrying unit, at least a reaction unit, a wire transporting unit, and a guiding unit. The carrying unit includes at least a hole, and the reaction unit is disposed on one side of the hole. The reaction unit includes at least a reaction area, which includes a hydrophilic material containing a detection reagent. The wire transporting unit is disposed on the other side of the hole and includes a sampling end and a transporting end. The guiding unit is in contact with the reaction unit and the transporting end. The guiding unit collects a test sample through the transporting end and provides at least a part of the test sample to react with the detection reagent. The detection device adopts the wire transporting unit to replace the pipette for collecting the test sample without directly contacting the detection area with the sample source.
    Type: Application
    Filed: September 28, 2015
    Publication date: December 29, 2016
    Inventors: Chao-Min CHENG, Mei-Jou TSAI
  • Patent number: 9469529
    Abstract: The present invention provides a fiber base sensor and the fabricating method thereof. More specifically, one of the main goals of the present invention is to solve the problem existing in the prior art of the failure of forming a plurality of nano-particles on the surface of the fiber base sensor evenly by utilizing self-assembly process with the nano-imprint process. Furthermore, the another goal of the present invention is to provide detail parameters required in the said nano-imprinting process for avoiding the efficiency drop caused by over-embedding the nano-particles into the fiber based sensor.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: October 18, 2016
    Assignee: National Tsing Hua University
    Inventors: De-Hui Wan, Shih-Yu Tseng, Chung-Yao Yang, Szu-Ting Lin, Chao-Min Cheng
  • Publication number: 20160220976
    Abstract: The present invention provides a manufacturing method for a detection device. The manufacturing method comprises dispensing a plurality of reagent droplets to a thin substrate by a dispensing unit and absorbing the plurality of reagent droplets by the thin substrate to form at least one detection area of the detection device.
    Type: Application
    Filed: July 14, 2015
    Publication date: August 4, 2016
    Inventors: Shang-Chi LIN, Chun-Wei LEE, Shueh-Yao CHU, Chao-Min CHENG, Fan-Gang TSENG