Patents by Inventor Chao-Wei Hwang

Chao-Wei Hwang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200297474
    Abstract: The present invention provides an implantable bioreactor comprising cells enclosed within an enclosure, said cells being capable of producing paracrine factors, wherein the enclosure is collapsible or expandable or both or neither, wherein the enclosure is semipermeable such that it provides containment of the cells preventing the egress of the cells while further providing a barrier that shields the cells from immunological attack, and wherein the enclosure is permeable to the entire secretome of the cell including exosomes, nucleic acids and proteins. The implantable bioreactor can have various configurations and can house internally a cell culture matrix than can include hydrogels, microbeads, and nanofiber matrices along with other active agents.
    Type: Application
    Filed: October 5, 2018
    Publication date: September 24, 2020
    Inventors: Chao-Wei Hwang, Peter Johnston, Gary Gerstenblith, Robert G. Weiss, Gordon Tomaselli, Steven Schulman
  • Patent number: 10772716
    Abstract: A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: September 15, 2020
    Assignee: The Johns Hopkins University
    Inventors: Gary Gerstenblith, Jason Benkoski, George Coles, Chao-Wei Hwang, Peter Johnston, Gordon Tomaselli, Robert G. Weiss, Steven P. Schulman, Jeffrey A. Brinker
  • Patent number: 10729337
    Abstract: The present application relates to systems and methods for non-invasively determining at least one of left ventricular end diastolic pressure (LVEDP) or pulmonary capillary wedge pressure (PCWP) in a subject's heart, comprising: receiving, by a computer, a plurality of signals from a plurality of non-invasive sensors that measure a plurality of physiological effects that are correlated with functioning of said subject's heart, said plurality of physiological effects including at least one signal correlated with left ventricular blood pressure and at least one signal correlated with timing of heartbeat cycles of said subject's heart; training a machine learning model on said computer using said plurality of signals for periods of time in which said plurality of signals were being generated during a heart failure event of said subject's heart; determining said LVEDP or PCWP using said machine learning model at a time subsequent to said training and subsequent to said heart failure event.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: August 4, 2020
    Assignees: The Johns Hopkins University, Boston Scientific Scimed Inc.
    Inventors: Qian Liu, Nichaluk Leartprapun, Jackline Wanjala, Soumyadipta Acharya, Andrew Bicek, Viachaslau Barodka, Umang Anand, Majd Alghatrif, David Kass, B. Westbrook Bernier, Chao-Wei Hwang, Peter Johnston, Trent Langston
  • Publication number: 20200147358
    Abstract: Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.
    Type: Application
    Filed: December 27, 2019
    Publication date: May 14, 2020
    Inventors: Chao-Wei Hwang, Zhiyong Xia, Virginia E. Bogdan, Jeffrey A. Brinker, Gary Gerstenblith, Peter V. Johnston, Steven P. Schulman, Gordon Tomaselli, Robert G. Weiss
  • Patent number: 10561830
    Abstract: Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: February 18, 2020
    Assignee: The Johns Hopkins University
    Inventors: Chao-Wei Hwang, Zhiyong Xia, Virginia E. Bogdan, Jeffrey A. Brinker, Gary Gerstenblith, Peter V. Johnston, Steven P. Schulman, Gordon Tomaselli, Robert G. Weiss
  • Publication number: 20190314416
    Abstract: A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.
    Type: Application
    Filed: February 21, 2019
    Publication date: October 17, 2019
    Inventors: Gary Gerstenblith, Jason Benkoski, George Coles, Chao-Wei Hwang, Peter Johnston, Gordon Tomaselli, Robert G. Weiss, Steven P. Schulman
  • Patent number: 10376682
    Abstract: Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: August 13, 2019
    Assignee: The Johns Hopkins University
    Inventors: Chao-Wei Hwang, Hala J. Tomey, Jon R. Resar, Robert C. Matteson, III, George L. Coles, Jr., Jason J. Benkoski, Morgana M. Trexler
  • Publication number: 20180160917
    Abstract: The present application relates to systems and methods for non-invasively determining at least one of left ventricular end diastolic pressure (LVEDP) or pulmonary capillary wedge pressure (PCWP) in a subject's heart, comprising: receiving, by a computer, a plurality of signals from a plurality of non-invasive sensors that measure a plurality of physiological effects that are correlated with functioning of said subject's heart, said plurality of physiological effects including at least one signal correlated with left ventricular blood pressure and at least one signal correlated with timing of heartbeat cycles of said subject's heart; training a machine learning model on said computer using said plurality of signals for periods of time in which said plurality of signals were being generated during a heart failure event of said subject's heart; determining said LVEDP or PCWP using said machine learning model at a time subsequent to said training and subsequent to said heart failure event.
    Type: Application
    Filed: May 5, 2016
    Publication date: June 14, 2018
    Applicants: The Johns Hopkins University, Boston Scientific Scimed Inc.
    Inventors: Qian Liu, Nichaluk Leartprapun, Jackline Wanjala, Soumyadipta Acharya, Andrew Bicek, Viachaslau Barodka, Umang Anand, Majd Alghatrif, David Kass, B. Westbrook Bernier, Chao-Wei Hwang, Peter Johnston, Trent Langston
  • Publication number: 20170245976
    Abstract: An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the cells contained within the bioreactor. Two broad classes of implantable bioreactors are envisioned, encompassing devices for both systemic delivery of the bio-products and local delivery at the target tissue. Bioreactors of both classes can be implanted via surgery, through percutaneous techniques, or other techniques which effect implantation.
    Type: Application
    Filed: March 23, 2017
    Publication date: August 31, 2017
    Inventors: Gary Gerstenblith, Jason Benkoski, Jeffrey Brinker, George Coles, Chao-Wei Hwang, Peter Johnston, Gordon Tomaselli, Robert G. Weiss, Steven P. Schulman
  • Publication number: 20170028181
    Abstract: Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
    Type: Application
    Filed: October 11, 2016
    Publication date: February 2, 2017
    Inventors: Chao-Wei Hwang, Hala J. Tomey, Jon R. Resar, Robert C. Matteson, III, George L. Coles, JR., Jason J. Benkoski, Morgana M. Trexler
  • Patent number: 9504586
    Abstract: Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: November 29, 2016
    Assignee: The Johns Hopkins University
    Inventors: Chao-Wei Hwang, Hala J. Tomey, Jon R. Resar, Robert C. Matteson, III, George L. Coles, Jr., Jason J. Benkoski, Morgana M. Trexler
  • Publication number: 20160235956
    Abstract: Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.
    Type: Application
    Filed: October 7, 2014
    Publication date: August 18, 2016
    Inventors: Chao-Wei Hwang, Zhiyong Xia, Virginia E. Bogdan, Jeffrey A. Brinker, Gary Gerstenblith, Peter V. Johnston, Steven P. Schulman, Gordon Tomaselli, Robert G. Weiss
  • Publication number: 20150335788
    Abstract: A therapeutic patch includes at least one layer of a nanofiber fabric and at least one of a plurality of stem cells or a plurality of stem cell-derived paracrine factors embedded in the nanofiber fabric. The therapeutic patch is produced such that the nanofiber fabric is formed of a nanofiber web.
    Type: Application
    Filed: March 5, 2015
    Publication date: November 26, 2015
    Inventors: Zhiyong Xia, Chao-Wei Hwang, Xiomara Calderon-Colon, Virginia E. Bogdan, Peter V. Johnston
  • Publication number: 20150217030
    Abstract: Certain embodiments according to the present invention provide a method for forming medical devices conformally coated with a hydrogel having a wide variety of therapeutic uses. In one aspect, certain embodiments of the invention provide a method for forming a hydrogel-coated medical device comprising immersing a medical device in a polymer solution to form an adhesive layer on an outer surface of the medical device and contacting the medical device with a hydrogel precursor solution having a pH of less than 7 to react the adhesive layer with the hydrogel precursor solution and form a conformal hydrogel coating.
    Type: Application
    Filed: February 5, 2015
    Publication date: August 6, 2015
    Inventors: Jason J. Benkoski, Peter V. Johnston, Chao-Wei Hwang, Gary Gerstenblith, Robert G. Weiss, Gordon Tomaselli, Steven P. Schulman, Jeffrey A. Brinker
  • Publication number: 20150209299
    Abstract: A medical device includes a plurality of drug-eluting nanofibers directly or indirectly located over an outer surface of the medical device, or utilized independently as a tissue engineering scaffold. The plurality of drug-eluting nanofibers include one or more therapeutic agents.
    Type: Application
    Filed: January 28, 2015
    Publication date: July 30, 2015
    Inventors: Zhiyong Xia, Chao-Wei Hwang
  • Publication number: 20140188213
    Abstract: Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
    Type: Application
    Filed: February 13, 2014
    Publication date: July 3, 2014
    Applicant: Johns Hopkins University
    Inventors: Chao-Wei Hwang, Hala J. Tomey, Jon R. Rosar, Robert C. Matteson, George L/ Coles, Jason J. Benkoski, Morgana M. Trexler
  • Patent number: 8696740
    Abstract: Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
    Type: Grant
    Filed: January 5, 2011
    Date of Patent: April 15, 2014
    Assignee: The Johns Hopkins University
    Inventors: Chao-Wei Hwang, Hala J. Tomey, Jon R. Rosar, Robert C. Matteson, III, George L. Coles, Jr., Jason J. Benkoski, Morgana M. Trexler
  • Publication number: 20120083767
    Abstract: An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the cells contained within the bioreactor. Two broad classes of implantable bioreactors are envisioned, encompassing devices for both systemic delivery of the bio-products and local delivery at the target tissue. Bioreactors of both classes can be implanted via surgery, through percutaneous techniques, or other techniques which effect implantation.
    Type: Application
    Filed: October 3, 2011
    Publication date: April 5, 2012
    Applicant: The Johns Hopkins University
    Inventors: Gary Gerstenblith, Jason Benkoski, Jeffrey Brinker, George Coles, Chao-Wei Hwang, Peter Johnston, Gordon Tomaselli, Robert G. Weiss, Steven P. Schulman
  • Publication number: 20120010698
    Abstract: Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
    Type: Application
    Filed: January 5, 2011
    Publication date: January 12, 2012
    Inventors: Chao-Wei Hwang, Hala J. Tomey, Jon R. Rosar, Robert C. Matteson, III, George L. Coles, JR., Jason J. Benkoski, Morgana M. Trexler
  • Patent number: 7494482
    Abstract: Methods and devices for transmitting micromechanical forces locally to induce surface convolutions into tissues on the millimeter to micron scale for promoting wound healing are presented. These convolutions induce a moderate stretching of individual cells, stimulating cellular proliferation and elaboration of natural growth factors without increasing the size of the wound. Micromechanical forces can be applied directly to tissue, through biomolecules or the extracellular matrix. This invention can be used with biosensors, biodegradable materials and drug delivery systems. This invention will also be useful in pre-conditioned tissue-engineering constructs in vitro. Application of this invention will shorten healing times for wounds and reduce the need for invasive surgery.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: February 24, 2009
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Dennis P. Orgill, Quentin Gavin Eichbaum, Sui Huang, Chao-Wei Hwang, Donald E. Ingber, Vishal Saxena, Evan Stuart Garfein