Abstract: Provided herein are compounds having the following structure: or a pharmaceutically acceptable salt, tautomer, stereoisomer, or enantiomer thereof, wherein the substituents are as defined herein compositions comprising an effective amount of a compound, and methods for inhibiting activity of cyclin-dependent kinases.

Abstract: An optical member driving mechanism is provided. The optical member driving mechanism includes a first movable portion used for connecting an optical element, a fixed portion, a first driving assembly used for driving the first movable portion to rotate relative to the fixed portion, and a guiding assembly having a first intermediate element. The first movable portion is movable relative to the fixed portion. The guiding assembly is used for applying a first stabilized force to the first movable portion for making the first intermediate element be in contact with the first movable portion or the fixed portion. The first movable portion is rotatable relative to the fixed portion.

Abstract: Provided is a display drive system, including: a plurality of drive units and a control unit. The plurality of drive units are connected to a lamp panel, and at least one of the plurality of drive units is configured to drive, during a display stage, the lamp panel to emit light. The control unit is connected to the plurality of drive units, and is configured to detect an operating state of the drive units driving the lamp panel to emit light. In response to detecting that a first drive unit is abnormal, the lamp panel is driven, by a second drive unit, to emit light, wherein the first drive unit is at least one of the drive units driving the lamp panel to emit light, and the second drive unit is at least one of the plurality of drive units other than the first drive unit.

Abstract: An electric window covering has a covering material, a driving device, a microcontroller, a position detecting module and a trigger detecting module. The position detecting module detects a position of a lower end of the covering material to generate a position information. The microcontroller compares the position information with a reference position to generate a position relationship with respect to the reference position. The trigger detecting module detects whether the covering material is moved by an external force for generating a detecting result. When the microcontroller determines that a trigger event is received according to the detecting result, the microcontroller configures the driving device to move the covering material according to the position relationship and the trigger event.

Abstract: The present application relates to a silicone oil-based immersion coolant for an electronic component. The silicone oil-based immersion coolant for an electronic component includes a base oil and an additive. The base oil includes a low-viscosity silicone oil. The additive includes a silicone oil diluent and a thermally conductive inorganic filler. The viscosity of the low-viscosity silicone oil is less than or equal to 1000 cSt. The thermally conductive inorganic filler is an insulating filler. Based on the mass of the immersion coolant, a mass percentage content of the base oil is in a range from 70% to 85%, a mass percentage content of the silicone oil diluent is in a range from 10% to 20%, and a mass percentage content of the thermally conductive inorganic filler is in a range from 5% to 10%.

Abstract: The disclosure belongs to the field of underground energy storage, and particularly provides a large-deformation underground energy storage device, including a body. The body includes a rubber sealing layer, a negative Poisson's ratio material layer, a large deformation concrete layer and rock layers sequentially nested from inside to outside; an internal storage space is formed in the rubber sealing layer, the negative Poisson's ratio material layer includes a plurality of negative Poisson's ratio material elements connected in sequence, and the large deformation concrete layer is cast from deformable concrete.

Abstract: An illuminated touchpad includes a panel, a light guide layer and a circuit board. The panel includes a first light transmitting region and a second light transmitting region. The light guide layer includes a first light guide region and a second light guide region. The circuit board includes a controller, a touch module, a first light source and a second light source. The controller controls the first light source to emit light, such that the first light guide region guides the light emitted by the first light source to the first light transmitting region. When the touch module senses that the first light transmitting region is touched, the controller controls the second light source to emit light, such that the second light guide region guides the light emitted by the second light source to the second light transmitting region.

Abstract: Disclosed is a microreactor for continuous flow synthesis of 2,5-furandicarboxylic acid, the microreactor includes a first container, a collection device, an injection pump, a first flow pump, a second flow pump, a first microreactor substrate, ion exchange resin adsorption pipes, activated carbon adsorption pipes, a second microreactor substrate, an oxygen source, a first T-connector, a second T-connector, and a third T-connector; where the first container is connected to the first T-connector via the first flow pump, the injection pump is connected to the first T-connector, the third T-connector is connected to the first T-connector and the first microreactor substrate, respectively, the first microreactor substrate is connected to the ion exchange resin adsorption pipes, the activated carbon adsorption pipes, the second T-connector, and the second microreactor substrate in sequence, and the oxygen source is connected to the second T-connector.

Abstract: A device for separating and recovering flat-plate catalyst powder and a method for determining a wear ratio are provided. The device includes a powder separation unit and a powder recovery unit, a powder accumulation bin is respectively connected with a shell and a catalyst powder outlet, a cyclone outlet is configured on an inner side of a recovery shell, and a primary filter and a secondary filter are configured on an inner side wall of the recovery shell.

Abstract: A semiconductor device includes a plurality of channel layers vertically separated from one another. The semiconductor device also includes an active gate structure comprising a lower portion and an upper portion. The lower portion wraps around each of the plurality of channel layers. The semiconductor device further includes a gate spacer extending along a sidewall of the upper portion of the active gate structure. The gate spacer has a bottom surface. Moreover, a dummy gate dielectric layer is disposed between the gate spacer and a topmost channel layer of plurality of channel layers. The dummy gate dielectric layer is in contact with a top surface of the topmost channel layer, the bottom surface of the gate spacer, and the sidewall of the gate structure.

Abstract: A package structure including a first substrate and a second substrate is provided. The first substrate includes first bumps with first lateral dimension and second bumps with second lateral dimension. The first bumps are distributed in a first region of the first substrate, and the second bumps are distributed in the second region of the first substrate, wherein the first lateral dimension is greater than the second lateral dimension, and a first bump height of the first bumps is smaller than a second bump height of the second bumps. The second substrate includes conductive terminals electrically connected to the first bumps and the second bumps.

Abstract: An optical element driving mechanism includes a movable assembly, a fixed assembly, and a driving assembly. The movable assembly is configured to be connected to an optical element. The movable assembly is movable relative to the fixed assembly. The driving assembly is configured to drive the movable assembly to move relative to the fixed assembly in a range of motion. The optical element driving mechanism further includes a positioning assembly configured to position the movable assembly at a predetermined position relative to the fixed assembly when the driving assembly is not operating.

Abstract: A semiconductor device includes a substrate, a semiconductor fin protruding from the substrate, an isolation layer disposed above the substrate, a dielectric fin with a bottom portion embedded in the isolation layer, and a gate structure over top and sidewall surfaces of the semiconductor fin and the dielectric fin. The semiconductor fin has a first sidewall and a second sidewall facing away from the first sidewall. The isolation layer includes a first portion disposed on the first sidewall of the semiconductor fin and a second portion disposed on the second sidewall of the semiconductor fin. A top portion of the dielectric fin includes an air pocket with a top opening sealed by the gate structure.

Abstract: The present application discloses a differential drive device applied to an AGV, relating to the field of wheeled drivers, and being able to effectively reduce the total height of the differential drive device. The differential drive device includes a differential drive unit (2), a top plate (1) and an outer cover (3). The top plate (1) is installed on a top end of the outer cover (3). The differential drive unit (2) is located in the outer cover (3) at a lower side of the top plate (1). The top plate (1) is supported on the differential drive unit (2). An inner side wall of the outer cover (3) is circular-shaped. The present application applies to apparatuses with transportation functions.

Abstract: A low-temperature smoking body and a preparation method thereof are disclosed. The low-temperature smoking body includes tobacco particles. The tobacco particle includes a particle body and a shell wrapped on the particle body. A carrier is distributed in the particle body and/or the shell. The carrier includes at least one of a raw tobacco material, a non-tobacco material, and a porous material. The carrier carries a smoking agent, and the smoking agent includes a tobacco extract and/or an atomizer. In addition, a preparation method of the low-temperature smoking body is further disclosed. The low-temperature smoking body has better smoking stability and uniformity, and the tobacco particles having core-shell structures can effectively solve the problem of liquid leakage.

Abstract: Abnormally-shaped tobacco granules are provided. The tobacco granules comprise a tobacco granule body and a coating attached to the surface of the tobacco granule body. The coating contains an adhesive. The surface of the abnormally-shaped tobacco granule has one or more grooves and/or ridges, and/or, the abnormally-shaped tobacco granule has through holes therein. The surface grooves of the abnormally-shaped tobacco granules can serve as smoke channels after the tobacco granules are bonded, cured and shaped, so that the air permeability inside a total-granule tobacco product is greatly improved. The smoking resistance of cigarettes is reduced. The flammability of cigarettes is improved and the consumption of tobacco raw materials is reduced. A preparation method of the abnormally-shaped tobacco granules, a tobacco product comprising the abnormally-shaped tobacco granules, and a preparation method thereof are also provided.

Abstract: The present invention relates to nucleic acid sequences for detecting soybean plant DBN8002 and detection methods thereof, wherein said nucleic acid sequences comprise SEQ ID NO: 1 or a complementary sequence thereof, and/or SEQ ID NO: 2 or a complementary sequence thereof. The soybean plant DBN8002 of the present invention has good resistance against Lepidoptera insects as well as good tolerance to glufosinate herbicide without compromising the yield, and the detection methods can accurately and rapidly identify whether a biological sample contains the DNA molecule of the transgenic soybean event DBN8002.

Abstract: Provided herein are methods of differentiating cell types in a cell population. The methods include removing at least some non-Chimeric Antigen Receptor (CAR)-T cells from a fluidic sample obtained from a subject without centrifuging the fluidic sample to produce a purified fluidic sample. The fluidic sample comprises CAR-T cells and the non-CAR-T cells. The methods also include capturing cells in the purified fluidic sample on a surface that comprises binding moieties that bind at least to the CAR-T cells to produce a captured cell population. In addition, the methods also include distinguishing the CAR-T cells from the non-CAR-T cells in the captured cell population using a trained machine learning model to produce a captured CAR-T cell population data set. Additional methods as well as related devices and systems are also provided.

Abstract: A backlight keyswitch includes a backlight module and a keyswitch body having a cap with a symbol. The backlight module disposed under the cap includes a light guide plate, a light-blocking sheet, a backlight circuit board having first, third, and second lighting units disposed in the light guide plate and arranged sequentially along a longitudinal direction for emitting first, third, and second color lights respectively, and a micro optical layer. The light-blocking sheet is located above the backlight circuit board and has a transparent region. The light guide plate is located between the light-blocking sheet and the backlight circuit board. The micro optical layer is parallel to the light guide plate and formed corresponding to the transparent region to guide the first, second, and third color lights to the symbol and has first and second clearance regions respectively adjacent to the first and second lighting units in the longitudinal direction.

Abstract: The present disclosure relates to a differential pressure driven burst-pipeline emergency blocking system. The system includes a valve body with flanges on opposite axial ends, a cylindrical valve sleeve connected with the inner wall of a flange end and having a through-hole in the valve sleeve wall. The wall of the valve sleeve is in movable fit with a valve spool having a U-shaped section. The working fluid through-hole in the valve sleeve is communicated with the inner chamber of the valve body and can be closed by a cylindrical surface of the valve spool. A horizontal push rod is in movable fit with a central hole at the left end of the valve spool, and opposite ends of the horizontal push rod are in movable fit with axial orifices of left and right support seats in the valve body respectively.