Abstract: Provided herein are Bridged Compounds having the following structures: wherein R1a, R1b, R1c, R1d, R2a, R2b, R2c, R2d, R3a, R3b, R3c, R3d, R4, R5, R6, R7, R8, m1, m2, m3, n2, n3, n4, q, X1, X2, Y1, Y2, L1 and ring A are as defined herein, compositions comprising an effective amount of a Bridged Compound, and methods for treating or preventing various diseases, e.g., pancreatic cancer, or a condition treatable or preventable by inhibition of the function of KRAS protein. In another aspect, a Bridged Compound is useful for treating or preventing a condition treatable or preventable by inhibition of the function of KRAS protein with G12D mutation. In another aspect, a Bridged Compound is useful for treating or preventing a condition treatable or preventable by inhibition of a RAS/MAPK pathway.

Abstract: An acoustic device includes a first sound producing component and a back cavity structure. The first sound producing component has a first front side and a first back side, wherein the first sound producing component is a high frequency sound unit, and the first front side faces a sound propagating opening of the acoustic device. The back cavity structure is connected to the first back side of the first sound producing component. The first sound producing component produces a first acoustic wave from the first front side towards the sound propagating opening, and the first sound producing component produces a second acoustic wave from the first back side towards a back cavity of the back cavity structure. The back cavity structure is configured to flatten a peak or a dip of a frequency response of the first sound producing component.

Abstract: A tracer diffusion device includes: a first container, for holding a first fluid containing a tracer; a second container, for holding a second fluid; a drilling pipe; wherein, a first end of the drilling pipe is connected to the first container; a second end of the drilling pipe is extended into a borehole; and the second end of the drilling pipe is equipped with a first sealing capsule and a second sealing capsule; a plurality of through holes are arranged on the drilling pipe between the first sealing capsule and the second sealing capsule; a unidirectional driving device, arranged on the drilling pipe, for injecting the first fluid from the first container into the borehole between the first sealing capsule and the second sealing capsule; and a bidirectional driving device, arranged between the second container and the first sealing capsule.

Abstract: A lighting keyboard includes a backlight module and at least one keyswitch. The backlight module includes a lighting unit, a light guide panel, and a lighting board for illuminating a keycap of the keyswitch. The light guide panel includes a panel hole to accommodate the lighting unit. The light guide panel further includes plural slots intervally surrounding the lighting unit. The lighting board includes a micro-structure region facing toward the light guide panel. Each of the slots of the light guide panel has a bulge portion protruding to the lighting unit. At two sides of the bulge portion, each of the slots forms two slots walls with an obtuse angle, thereby expanding the transmitting angle for the multi-color lights from the lighting unit and enhancing the light-mixing uniformity while illuminating the keycap.

Abstract: A backlight keyswitch includes a board, a backlight module and a keyswitch body having a cap with a symbol formed thereon. The backlight module disposed under the cap includes first and second ink layers, a light guide plate, a light-blocking sheet having a transparent region corresponding to the cap, and a backlight circuit board having first, third, and second lighting units disposed in the light guide plate and arranged sequentially along a longitudinal direction for emitting first, third, and second color lights respectively to be incident to the transparent region after light mixing. The first and second ink layers are formed on the light-blocking sheet and located outside the first and second lighting units. Colors of the first and second ink layers at least correspond to colors of the second and first color lights respectively to achieve a mixed color.

Abstract: A backlight keyswitch includes a backlight module and a keyswitch body having a cap with a symbol. The backlight module disposed under the cap includes a light guide plate, a light-blocking sheet, a backlight circuit board having first, third, and second lighting units disposed in the light guide plate and arranged sequentially along a longitudinal direction for emitting first, third, and second color lights respectively, and a micro optical layer. The light-blocking sheet is located above the backlight circuit board and has a transparent region. The light guide plate is located between the light-blocking sheet and the backlight circuit board. The micro optical layer is parallel to the light guide plate and formed corresponding to the transparent region to guide the first, second, and third color lights to the symbol and has first and second clearance regions respectively adjacent to the first and second lighting units in the longitudinal direction.

Abstract: Compounds are provided as inhibitors of CXCR2, having the structure:

Abstract: The disclosure herein provides bridged compounds as well as their compositions and methods of use. The compounds disclosed herein inhibit KRAS G12D activity and are useful in the treatment of various diseases including cancer.

Abstract: A backlight keyswitch includes a keycap, a support plate, a membrane circuit board and a backlight module. The support plate is disposed under the keycap. The membrane circuit board is disposed in parallel to the keycap and the support plate. The backlight module is disposed under the support plate, which includes a shielding sheet, a light guide panel, a lighting board and a protrusion structure. The shielding sheet includes a light permeable area corresponding to the keycap. The light guide panel is disposed under the shielding sheet. The lighting board is disposed under the light guide panel and includes a light source. The protrusion structure protrudes toward the light source and is formed on one of the support plate, the membrane circuit board and the shielding sheet. The protrusion structure reflects at least partial light of the light source to enter the light guide panel for lateral transmission.

Abstract: A backlight module for illuminating a keycap includes a shielding sheet, a light guide panel, a lighting board disposed under the light guide panel, and a first protrusion structure. The shielding sheet includes a light permeable area. The light guide panel is disposed under the shielding sheet and has a light guide hole for accommodating a light source of the lighting board. The first protrusion structure is formed on the shielding sheet and protrudes toward the light source. The first protrusion structure is at least partially not overlapped with the light source in a vertical direction, for reflecting and scattering at least partial light of the light source to enter the light guide panel for lateral transmission.

Abstract: A display apparatus and an fingerprint sensing method thereof are provided. A display panel of the display apparatus has a pixel circuit array, an in-display touch sensor array, and an in-display fingerprint sensor array. A driving circuit drives the in-display fingerprint sensor array to read a fingerprint image. A current display frame period is divided into a plurality of unit periods, each of the unit periods includes at least one fingerprint sensing period and one or both of a display driving period and a touch sensing period. The driving circuit resets a current fingerprint sensor in the in-display fingerprint sensor array during a first fingerprint sensing period among these fingerprint sensing periods of the first display frame period. The driving circuit reads a sensing result of the current fingerprint sensor during a second fingerprint sensing period succeeding to the first fingerprint sensing period.

Abstract: A back light module is applied to a lighting keyboard with a plurality of keyswitches and includes a lighting unit, a light guide plate, a light penetrating membrane, a light calibration layer and an adhering component. The light guide plate has an opening used to accommodate the lighting unit. The light penetrating membrane is disposed on the light guide plate. The light calibration layer is disposed on the light penetrating membrane and has a second contour. The adhering component is disposed between the light guide plate and the light penetrating membrane, and has a first contour greater than the second contour. The adhering component includes a front region, a rear region and a hollow region. The front region is covered by the light calibration layer. The rear region is partly covered or not covered by the light calibration layer. The hollow region corresponds to and is larger than the opening.

Abstract: A method of orthopedic treatment includes steps of: by using a computer aided design (CAD) tool based on profile data that is related to a to-be-treated part of a bone of a patient, obtaining a model of a preliminary instrument that substantially fits the to-be-treated part; by using the CAD tool, obtaining a model of a patient specific instrument (PSI) based on the model of the preliminary instrument; producing the PSI based on the model of the PSI, the PSI being adjustable; performing medical operation on the to-be-treated part, and then attaching the PSI to the to-be-treated part; after attaching the PSI to the to-be-treated part, adjusting the PSI such that the PSI is adapted to real conditions of the to-be-treated part.

Abstract: A backlight keyswitch includes a cap with a symbol, and a backlight module under the cap and having first and second light modifying layers, a light guide plate, a light-blocking sheet having a transparent region corresponding to the cap, and first, third, and second lighting units arranged sequentially along a longitudinal direction for emitting first, third, and second color lights. The first and second light modifying layers might be ink layers formed on the light-blocking sheet and located outside the first and second lighting units, with colors of the first and second ink layers at least corresponding to colors of the second and first color lights respectively to achieve a mixed color. Alternatively, the first and second light modifying layers might be adhesive layers arrange parallel to the light guide plate, the first and second adhesive layers scattering a respective one of the first and second color light.

Abstract: The fuse device includes a plurality of fuse circuits, a global latch circuit and a plurality of local latch circuits. The global latch circuit is coupled to the fuse circuits. The global latch circuit is used to sense the blown states of the fuse circuits at different times, so as to output the fuse information of the fuse circuits at the different times. The local latch circuits are coupled to the global latch circuits. Each of these local latch circuits latches the fuse information output by the global latch circuit at the different times.

Abstract: An edge-press molding element is part of a glass-bending tooling that includes a contoured-ring, gasket form factor. The edge-press molding element operates by self-weight bending a glass pane under a thermal load. The glass pane bends under molding conditions where a temperature differential of as low as 30° C. up to 100° C. is achieved between an edge of the glass pane and the center.

Abstract: A digital speckle based online water wall stress monitoring method and device, and the method includes the following steps: arrange an online stress monitoring device on the side of the water wall to be monitored; determine a plurality of monitoring points according to the area of the water wall, and set the motion track of the online stress monitoring device for speckle image acquisition according to the determined monitoring points; acquire the real-time speckle image of each monitoring point in real time after acquiring the initial speckle image of each monitoring point; compare the real-time speckle images with the initial speckle images, and determine whether the stress of the water wall changes according to the comparison results. The invention adopts non-contact digital image technology, and determines the difference between the real-time and initial speckle images of the water wall to realize the stress monitoring.

Abstract: A package structure includes a cover and a cell disposed within the cover. The cell includes a membrane, an actuating layer and an anchor structure. The membrane includes a first membrane subpart and a second membrane subpart, wherein the first membrane subpart and the second membrane subpart are opposite to each other in a top view. The actuating layer is disposed on the first membrane subpart and the second membrane subpart in the top-view direction. The membrane is anchored by the anchor structure. The first membrane subpart includes a first anchored edge which is fully or partially anchored, and edges of the first membrane subpart other than the first anchored edge are non-anchored. The second membrane subpart includes a second anchored edge which is fully or partially anchored, and edges of the second membrane subpart other than the second anchored edge are non-anchored.