Patents by Inventor Chaozhong Cai

Chaozhong Cai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GPR120 agonists for the treatment of type II diabetes
    Patent number: 10618893
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, G, and Q are defined herein; and wherein R11, R21, R41, RB1 and G1, are defined herein.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: April 14, 2020
    Assignee: JANSSEN PHARMACEUTICALS NV
    Inventors: Zhihua Sui, Chaozhong Cai, Xuqing Zhang
  • GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
    Publication number: 20190071435
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, G, and Q are defined herein; and wherein R11, R21, R41, RB1 and G1, are defined herein.
    Type: Application
    Filed: November 5, 2018
    Publication date: March 7, 2019
    Inventors: Zhihua Sui, Chaozhong Cai, Xuqing Zhang
  • Compounds as opioid receptor modulators
    Patent number: 10213415
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: February 26, 2019
    Assignee: Janssen Pharmaceutica NV
    Inventors: Henry J. Breslin, Chaozhong Cai, Wei He, Robert W. Kavash
  • NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS
    Publication number: 20180325870
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Application
    Filed: June 7, 2017
    Publication date: November 15, 2018
    Inventors: HENRY J. BRESLIN, CHAOZHONG CAI, WEI HE, ROBERT W. KAVASH
  • GPR120 agonists for the treatment of type II diabetes
    Patent number: 10118922
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, G, and Q are defined herein; and wherein R11, R21, R41, RB1 and G1, are defined herein.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: November 6, 2018
    Assignee: JANSSEN PHARMACEUTICA NV
    Inventors: Zhihua Sui, Chaozhong Cai, Xuqing Zhang
  • Compounds as opioid receptor modulators
    Patent number: 9700542
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: July 11, 2017
    Assignee: Janssen Pharmaceutica NV
    Inventors: Henry J. Breslin, Chaozhong Cai, Wei He, Robert W. Kavash
  • NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS
    Publication number: 20160030393
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Application
    Filed: October 12, 2015
    Publication date: February 4, 2016
    Inventors: HENRY J. BRESLIN, CHAOZHONG CAI, WEI HE, ROBERT W. KAVASH
  • Compounds as opioid receptor modulators
    Patent number: 9205076
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: December 8, 2015
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Henry J. Breslin, Chaozhong Cai, Wei He, Robert W. Kavash
  • Octahydro-cyclopentapyrrolyl antagonists of CCR2
    Patent number: 9024017
    Abstract: The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, Z1 and Z2 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: May 5, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Chaozhong Cai, David F. McComsey, Zhihua Sui, Fu-An Kang
  • 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators
    Patent number: 8846655
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, Ra, and Y are defined herein.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: September 30, 2014
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Steven J. Coats, Haiyan Bian, Chaozhong Cai, Bart L. DeCorte, Li Liu, Mark J. Macielag, Scott L. Dax, Philip M. Pitis, Peter J. Connolly, Wei He
  • GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
    Publication number: 20140275179
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, G, and Q are defined herein; and wherein R11, R21, R41, RB1 and G1, are defined herein.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 18, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Zhihua Sui, Chaozhong Cai, Xuqing Zhang
  • NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS
    Publication number: 20140256779
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Application
    Filed: May 20, 2014
    Publication date: September 11, 2014
    Applicant: Jannsen Pharmaceutica, N.V.
    Inventors: Henry J. Breslin, Chaozhong Cai, Wei He, Robert W. Kavash
  • Compounds as opioid receptor modulators
    Patent number: 8772325
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: July 8, 2014
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Henry J. Breslin, Chaozhong Cai, Wei He, Robert W. Kavash
  • Pyrimidine compounds as delta opioid receptor modulators
    Patent number: 8685990
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: April 1, 2014
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Steven J. Coats, Haiyan Bian, Peter J. Connolly, Gilles Bignan, Chaozhong Cai, Scott L. Dax, Bart L. DeCorte, Shu-Chen Lin, Li Liu, Mark J. Macielag, Philip M. Pitis, Yue-Mei Zhang, Bin Zhu, Wei He
  • NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS
    Publication number: 20140039024
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Application
    Filed: October 3, 2013
    Publication date: February 6, 2014
    Inventors: HENRY J. BRESLIN, CHAOZHONG CAI, WEI HE, ROBERT W. KAVASH
  • OCTAHYDRO-CYCLOPENTAPYRROLYL ANTAGONISTS OF CCR2
    Publication number: 20140024646
    Abstract: The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, Z1 and Z2 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
    Type: Application
    Filed: July 16, 2013
    Publication date: January 23, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Chaozhong Cai, David F. MCCOMSEY, Zhihua Sui, Fu-An Kang
  • Compounds as opioid receptor modulators
    Patent number: 8609709
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: December 17, 2013
    Assignee: Janssen Pharmaceutica, N. V.
    Inventors: Henry J. Breslin, Chaozhong Cai, Wei He, Robert W. Kavash
  • PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS
    Publication number: 20130310358
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
    Type: Application
    Filed: July 25, 2013
    Publication date: November 21, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventors: Steven J. Coats, Haiyan Bian, Peter J. Connolly, Giles Bignan, Chaozhong Cai, Scott L. Dax, Bart L. DeCorte, Shu-Chen Lin, Li Liu, Mark J. Macielag, Philip M. Pitis, Yue-Mei Zhang, Bin Zhu, Wei He
  • Pyrimidine compounds as delta opioid receptor modulators
    Patent number: 8513271
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: August 20, 2013
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Steven J. Coats, Haiyan Bian, Peter J. Connolly, Gilles Bignan, Chaozhong Cai, Scott L. Dax, Bart L. DeCorte, Shu-Chen Lin, Li Liu, Mark J. Macielag, Philip M. Pitis, Yue-Mei Zhang, Bin Zhu, Wei He
  • Compounds as opioid receptor modulators
    Patent number: 8344011
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: January 1, 2013
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Henry J. Breslin, Chaozhong Cai, Wei He, Robert W. Kavash