Patents by Inventor Chaozhong Cai

Chaozhong Cai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS
    Publication number: 20120302541
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, Ra, and Y are defined herein.
    Type: Application
    Filed: October 28, 2010
    Publication date: November 29, 2012
    Inventors: Steven J. Coats, Haiyan Bian, Chaozhong Cai, Bart L. DeCorte, Li Liu, Mark J. Macielag, Scott L. Dax, Philip M. Pitis, Peter J. Connolly, Wei He
  • 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of CCR2
    Patent number: 8269015
    Abstract: The present invention comprises compounds of Formula (I). wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: September 18, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Xuqing Zhang, Heather Rae Hufnagel, Chaozhong Cai, James C. Lanter, Thomas P. Markotan, Zhihua Sui
  • Piperidyl acrylamide antagonists of CCR2
    Patent number: 8188287
    Abstract: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5 and X are as defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is uveitis, including acute, recurring or chronic uveitis. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: May 29, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Chaozhong Cai, Zhihua Sui
  • PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS
    Publication number: 20110269759
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, Ra, and Y are defined herein.
    Type: Application
    Filed: October 28, 2010
    Publication date: November 3, 2011
    Inventors: Steven J. COATS, Haiyan BIAN, Chaozhong CAI, Bart L. DECORTE, Li LIU, Mark J. MACIELAG, Scott L. DAX, Philip M. PITIS, Peter J. CONNOLLY, Wei HE
  • PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS
    Publication number: 20110105520
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
    Type: Application
    Filed: October 28, 2010
    Publication date: May 5, 2011
    Inventors: STEVEN J. COATS, HAIYAN BIAN, PETER J. CONNOLLY, GILLES BIGNAN, CHAOZHONG CAI, SCOTT L. DAX, BART L. DECORTE, SHU-CHEN LIN, LI LIU, MARK J. MACIELAG, PHILIP M. PITIS, YUE-MEI ZHANG, BIN ZHU, WEI HE
  • NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS
    Publication number: 20100324051
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Application
    Filed: July 19, 2010
    Publication date: December 23, 2010
    Inventors: Henry J. Breslin, Chaozhong Cai, Wei He, Robert W. Kavash
  • 4-AZETIDINYL-1-HETEROARYL-CYCLOHEXANE ANTAGONISTS OF CCR2
    Publication number: 20100267688
    Abstract: The present invention comprises compounds of Formula (I). wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
    Type: Application
    Filed: April 15, 2010
    Publication date: October 21, 2010
    Inventors: Xuqing Zhang, Heather Rae Hufnagel, Chaozhong Cai, James C. Lanter, Thomas P. Markotan, Zhihua Sui
  • Compounds as opioid receptor modulators
    Patent number: 7786158
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: August 31, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Henry J. Breslin, Chaozhong Cai, Wei He, Robert W. Kavash
  • Compounds as opioid receptor modulators
    Patent number: 7741356
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: June 22, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Henry J. Breslin, Chaozhong Cai, Wei He, Robert W. Kavash
  • PROCESS FOR THE PREPARATION OF OPIOID MODULATORS
    Publication number: 20100152460
    Abstract: The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders.
    Type: Application
    Filed: November 25, 2009
    Publication date: June 17, 2010
    Inventors: Chaozhong Cai, Wei He
  • PROCESS FOR THE PREPARATION OF OPIOD MODULATORS
    Publication number: 20100036132
    Abstract: The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders.
    Type: Application
    Filed: October 16, 2009
    Publication date: February 11, 2010
    Inventors: Chaozhong Cai, Wei He
  • PIPERIDYL ACRYLAMIDE ANTAGONISTS OF CCR2
    Publication number: 20090318498
    Abstract: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5 and X are as defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is uveitis, including acute, recurring or chronic uveitis. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
    Type: Application
    Filed: June 19, 2009
    Publication date: December 24, 2009
    Inventors: Chaozhong Cai, Zhihua Sui
  • Process for the preparation of opioid modulators
    Patent number: 7629488
    Abstract: The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: December 8, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Chaozhong Cai, Wei He
  • NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS
    Publication number: 20080096888
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Application
    Filed: October 24, 2007
    Publication date: April 24, 2008
    Inventors: Henry Breslin, Chaozhong Cai, Wei He, Robert Kavash
  • Process for the preparation of opioid modulators
    Publication number: 20060211861
    Abstract: The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders.
    Type: Application
    Filed: March 6, 2006
    Publication date: September 21, 2006
    Inventors: Chaozhong Cai, Wei He
  • Process for the preparation of opioid modulators
    Publication number: 20060211863
    Abstract: The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders.
    Type: Application
    Filed: March 6, 2006
    Publication date: September 21, 2006
    Inventors: Chaozhong Cai, Wei He
  • Novel compounds as opioid receptor modulators
    Publication number: 20050203143
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Application
    Filed: March 14, 2005
    Publication date: September 15, 2005
    Inventors: Henry Breslin, Chaozhong Cai, Wei He, Robert Kavash