Abstract: A method of treating a calculi mass can include using an ultrasonic probe to produce acoustic energy and fragment the mass. The method can include varying the frequency at which fragmentation occurs to treat the mass with a resonant frequency. The ultrasonic probe can have a distal tip for contact with the mass, where the tip has a morphology for concentrating stress on the mass. The ultrasonic probe can have two or more ultrasonic horns to allow for higher voltage and power levels.

Abstract: An optical fiber having a distal end extending from a distal end of an endoscope can direct light to and from a target. An interferometer can receive first light pulses from a first frequency comb having a first repetition rate, form reference arm light pulses and measurement arm light pulses from the first light pulses, direct the measurement arm light pulses to and from the target via the optical fiber to form return light pulses, and interfere the return light pulses with the reference arm light pulses to form interferometer output pulses. A beamsplitter can interfere the interferometer output pulses with second light pulses from a second frequency comb having a second repetition rate to form system output pulses. Processor circuitry can determine, from a time duration between consecutive system output pulses, a spacing between the optical fiber and the target, and can take an action in response.

Abstract: A method is provided for vaporized hydrogen peroxide cleaning of a chamber. The method includes altering a temperature of air in the chamber from an initial temperature to a sterilization temperature over a first time period. The method also includes injecting vaporized hydrogen peroxide into air in the chamber to alter a relative humidity of hydrogen peroxide vapor in the chamber to a sterilization level over the first time period. The method also includes maintaining the temperature at the sterilization temperature and the relative humidity at the sterilization level over a second time period. The method also includes reducing the relative humidity from the sterilization level to a safe level over a third time period. In one embodiment, the method is provided for vaporized hydrogen peroxide cleaning of an interior chamber of an incubation container. In other embodiments, the incubation chamber featured in the method is provided.

Abstract: In a laser tissue ablation system, a distal end of an optical fiber can extend from an endoscope. The optical fiber can receive therapeutic laser light pulses at first times, receive measurement light pulses at second times, direct the therapeutic laser light pulses and the measurement light pulses toward a target, collect, as collected light pulses, at least some of the measurement light pulses that are reflected from the target, and direct, as return light pulses, at least some of the collected light pulses away from the distal end of the optical fiber. An optical detector can sense at least some of the return light pulses. Processor circuitry can perform a time-of-flight analysis of the sensed return light pulses to determine a spacing between the distal end of the optical fiber and the target and can generate a spacing data signal representing the determined spacing.

Abstract: A laser tissue ablation system can include an optical fiber, with a distal end being extendible from an endoscope body of an endoscope. The optical fiber can deliver therapeutic laser light from the distal end of the optical fiber toward a target site, and receive return light into the distal end of the optical fiber. The laser tissue ablation system can include a sensor that can spectrally measure the return light. The laser tissue ablation system can include processor circuitry that can form a first determination, from the spectral measurement of the return light, whether flashing event light is present in the return light. The flashing event light can be generated when a flashing event occurs at the distal end of the optical fiber. The processor circuitry can generate, in response to the first determination, a flashing event data signal that indicates whether the flashing event has occurred.

Abstract: To automate a pricing strategy for an otherwise unpriced service or item, prices may be generated through a plurality of different pricing models, via a pricing engine passing input data to a plurality of discrete pricing models. Those pricing models may pass data back to the pricing engine, which then adjudicates the results of the pricing models to identify a most-relevant pricing model for the particular unpriced service or item.

Abstract: A lithotripsy device can comprise a handpiece, a lithotripsy probe extending from the handpiece, an energization source configured to deliver an energy to a distal end of the lithotripsy probe, a suction passage extending from the distal end of the probe and through the handpiece, and a capture device comprising a container comprising a storage space, an entry port configured to couple to the handpiece at the suction passage, and an exit port, and a capture element connected to the container and configured to facilitate capture of stone fragments within the storage space. A method can comprise fragmenting stones with a lithotripsy device, drawing a vacuum through the lithotripsy device to pull stone fragments and waste fluid therethrough, pulling the vacuum through a stone capture device connected to the lithotripsy device, depositing stone fragments within the stone capture device using a capture element, and drawing the vacuum through the device.

Abstract: A system to deliver energy to treat a mobile calculus, the system can include a drill and a lateral energy emitter. The drill can be configured to drill a recess into the mobile calculus or a passage through the mobile calculus. The lateral energy emitter can be configured to be advanced into the recess or the passage and to transmit the energy internal to the mobile calculus to fragment the mobile calculus. In some examples, the system can include a deployable capture portion to constrain a stone relative to the capture portion.

Abstract: The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).

Abstract: A method for delivering surgical material comprises inserting a delivery device into an anatomic area, coupling a surgical material delivery system to the delivery device, the surgical material delivery system having a reservoir of surgical material, positioning an anatomic electrode relative to the anatomic area, applying a first charge to the anatomic electrode, dispensing surgical material from the delivery device, applying a second charge to surgical material leaving the delivery device opposite the first charge, and delivering charged surgical material to the anatomic area proximate the anatomic electrode via a directional-oriented electrostatic field.

Abstract: The present invention relates to compounds of formula (I) inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are phthalazine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).

Abstract: The present invention relates to compounds of formula (I) inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are (aza)quinoline 4-amines derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).

Abstract: A dehumidifying system and method for reducing humidity in ambient air is disclosed. The system includes a circulation unit, a refrigeration unit, a condensate receptacle for receiving condensate generated by the refrigeration unit, a controller to control both the circulation and refrigeration units, and wherein the controller receives input from one or more ambient sensors configured to sense ambient conditions, and a user interface configured to receive input from a user. The system implements variable speed control within the circulation and/or refrigeration unit to maximize efficiency or capacity under a current threshold, and enables the system to delay the need for defrost cycling during low temperature operation.

Abstract: The disclosed technology for preparing digital samples for synthesis of RF to simulate channels and GNSS satellites using GPUs includes receiving simulated position and velocity of an antenna, dividing the cycle into points to be converted into the synthesized signal, and computing the points. A first LUT includes pseudo random sequences combinable to produce a code that varies over time for encoding the channel, and a second LUT specifies linear combinations of the pseudo random sequences in the first LUT that produce channel codes to produce the digital sample points. Also included is using GPUs to generate the channel code for a point by mapping the channel code and time position, combining the code with data to be encoded, repeatedly applying the using and combining to produce points, using multiple GPU cores to encode sample points concurrently in the cycle, and sending an ordered sequence of points to a converter.

Abstract: System and techniques for target identification system are described herein. In an example, a system can include a medical instrument for ablating a target and a mechanism for removing the ablated target from an anatomic site into an evacuation path. The evacuation path can include a measurement chamber. The system can also include a turbulence-generation system that can generate turbulence in the measurement chamber. The system can also include a target-identification system that can determine a characteristic of at least a portion of the ablated target in the measurement chamber.

Abstract: A method of treating a calculi mass can include using an ultrasonic probe to produce acoustic energy and fragment the mass. The method can include varying the frequency at which fragmentation occurs to treat the mass with a resonant frequency. The ultrasonic probe can have a distal tip for contact with the mass, where the tip has a morphology for concentrating stress on the mass. The ultrasonic probe can have two or more ultrasonic horns to allow for higher voltage and power levels.

Abstract: The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3 (hereinafter P2X3 inhibitors); particularly the invention relates to compounds that are pyridopyrimidines derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).

Abstract: A clotting agent delivery system comprises a frame, a passageway extending along the frame, a discharge opening connected to the passageway, a clotting agent reservoir fluidly connected to the passageway to hold a clotting agent substance, a valve in the passageway to control flow of the substance through the passageway, and an actuator to allow propellent to flow into the passageway, wherein the valve and clotting agent reservoir cooperate to provide clotting agent substance to the discharge opening at constant pressure using the propellant. A method for delivering a clotting agent comprises inserting a delivery catheter into an anatomic area, coupling a clotting agent delivery system to the delivery catheter, the clotting agent delivery system having a reservoir of a clotting agent, operating a valve to release propellant for propelling the clotting agent, and conveying the propellant and the clotting agent to the delivery catheter at a constant pressure.

Abstract: An acoustic liquid transfer system comprises: a processor; a source holding component configured to hold a source microplate; a destination holding component configured to hold a destination microplate; an acoustic transducer configured to cause liquid to transfer between the source and destination microplates; and a controller configured to direct movements, according to an ordered picklist, of one or more of the: source holding component, destination holding component, and acoustic transducer.

Abstract: A method of performing a surgical procedure comprises inserting a medical instrument into anatomy of a patient to reach target tissue within an anatomical cavity, disinfecting anatomy within the patient with the medical instrument and performing treatment of the target tissue with the medical instrument. A medical device for providing disinfecting to a surgical site, the medical device comprises an elongate shaft extending from a proximal end to a distal end, an imaging device located proximate the distal end of the elongate shaft, a lighting element located proximate the distal end of the elongate shaft, a working channel extending at least partially through the elongate shaft and a disinfecting system attached to the elongate shaft to deliver a disinfecting capability proximate the distal end of the elongate shaft.