Abstract: Disclosed are compositions and methods for delaying or preventing idiopathic preterm

Abstract: Disclosed are compositions and methods for delaying or preventing idiopathic preterm birth.

Abstract: The disclosure is directed to a method of enhancing progesterone receptor (PR) activity in a mammal, which comprises administering a composition comprising an inhibitor of FK506 binding protein 51 (FKBP51) to a mammal in need thereof, such as a pregnant human female, whereby progesterone receptor activity in the mammal is enhanced as compared to a mammal not administered the composition. The method results in an extension of the gestation period and a decreased likelihood of preterm birth and fetal growth restriction.

Abstract: Disclosed are compositions and methods for delaying or preventing idiopathic preterm birth.

Abstract: The disclosure is directed to a method of enhancing progesterone receptor (PR) activity in a mammal, which comprises administering a composition comprising an inhibitor of FK506 binding protein 51 (FKBP51) to a mammal in need thereof, such as a pregnant human female, whereby progesterone receptor activity in the mammal is enhanced as compared to a mammal not administered the composition. The method results in an extension of the gestation period and a decreased likelihood of preterm birth and fetal growth restriction.

Abstract: Implementations described and claimed herein provide systems and methods systems and methods for managing network health, including optimizing a network. In one implementation, an alarm list for a subnetwork of a telecommunications network is obtained. The alarm list has alarm data captured from a plurality of network elements forming the subnetwork. Network data associated with a subset of the network elements is captured by traversing a circuit path in the subnetwork from a source to a destination. The subset of network elements disposed is along the circuit path. The alarm list is correlated with the network data to identify a related network issue. A root cause of the related network issue is determined. One or more recommendations for resolving the root cause of the related network issue are generated, and at least one of the recommendations is deployed in the subnetwork.

Abstract: The disclosure is directed to a method of enhancing progesterone receptor (PR) activity in a mammal, which comprises administering a composition comprising an inhibitor of FK506 binding protein 51 (FKBP51) to a mammal in need thereof, such as a pregnant human female, whereby progesterone receptor activity in the mammal is enhanced as compared to a mammal not administered the composition. The method results in an extension of the gestation period and a decreased likelihood of preterm birth and fetal growth restriction.

Abstract: Implementations described and claimed herein provide systems and methods systems and methods for managing network health, including optimizing a network. In one implementation, an alarm list for a subnetwork of a telecommunications network is obtained. The alarm list has alarm data captured from a plurality of network elements forming the subnetwork. Network data associated with a subset of the network elements is captured by traversing a circuit path in the subnetwork from a source to a destination. The subset of network elements disposed is along the circuit path. The alarm list is correlated with the network data to identify a related network issue. A root cause of the related network issue is determined. One or more recommendations for resolving the root cause of the related network issue are generated, and at least one of the recommendations is deployed in the subnetwork.

Abstract: Implementations described and claimed herein provide systems and methods systems and methods for managing network health, including alarm reduction in a subnetwork. In one implementation, an alarm list is received. The alarm list has alarm data captured from a plurality of remote nodes and consolidated at an aggregator node. A first alarm corresponding to an optical interface deployed in a circuit of a telecommunications subnetwork is identified from the alarm list. A topology associated with the optical interface is discovered by traversing a path of the circuit. An interface list is generated based on the topology. One or more alarms related to a root cause of the first alarm are identified based on a comparison of the interface list to the alarm list. The related alarms are correlated to the first alarm for concurrent resolution.

Abstract: Various systems and methods for caching and tiering in cloud storage are described herein. A system for managing storage allocation comprises a storage device management system to maintain an access history of a plurality of storage blocks of solid state drives (SSDs) managed by the storage device management system; and automatically configure each of a plurality of storage blocks to operate in cache mode or tier mode, wherein a ratio of storage blocks operating in cache mode and storage blocks operating in tier mode is based on the access history.

Abstract: One aspect of the present disclosure relates to a therapy delivery device for treating an obstetric or gynecological disorder other than urinary incontinence in a subject. The therapy delivery device can include a housing, at least one electrode, and a power source. The housing can be configured for implantation in a reproductive system of the subject. The at least one electrode can be connected to the housing and be configured to deliver an electrical signal to an autonomic nervous system nerve target. The power source can be in electrical communication with the at least one electrode.

Abstract: One aspect of the present disclosure relates to a therapy delivery device for treating an obstetric or gynecological disorder other than urinary incontinence in a subject. The therapy delivery device can include a housing, at least one electrode, and a power source. The housing can be configured for implantation in a reproductive system of the subject. The at least one electrode can be connected to the housing and be configured to deliver an electrical signal to an autonomic nervous system nerve target. The power source can be in electrical communication with the at least one electrode.

Abstract: Various systems and methods for caching and tiering in cloud storage are described herein. A system for managing storage allocation comprises a storage device management system to maintain an access history of a plurality of storage blocks of solid state drives (SSDs) managed by the storage device management system; and automatically configure each of a plurality of storage blocks to operate in cache mode or tier mode, wherein a ratio of storage blocks operating in cache mode and storage blocks operating in tier mode is based on the access history.

Abstract: One aspect of the present disclosure relates to a therapy delivery device for treating an obstetric or gynecological disorder other than urinary incontinence in a subject. The therapy delivery device can include a housing, at least one electrode, and a power source. The housing can be configured for implantation in a reproductive system of the subject. The at least one electrode can be connected to the housing and be configured to deliver an electrical signal to an autonomic nervous system nerve target. The power source can be in electrical communication with the at least one electrode.

Abstract: One aspect of the present disclosure relates to a therapy delivery device for treating an obstetric or gynecological disorder other than urinary incontinence in a subject. The therapy delivery device can include a housing, at least one electrode, and a power source. The housing can be configured for implantation in a reproductive system of the subject. The at least one electrode can be connected to the housing and be configured to delivery an electrical signal to an autonomic nervous system nerve target. The power source can be in electrical communication with the at least one electrode.

Abstract: Various systems and methods for caching and tiering in cloud storage are described herein. A system for managing storage allocation comprises a storage device management system to maintain an access history of a plurality of storage blocks of solid state drives (SSDs) managed by the storage device management system; and automatically configure each of a plurality of storage blocks to operate in cache mode or tier mode, wherein a ratio of storage blocks operating in cache mode and storage blocks operating in tier mode is based on the access history.

Abstract: Implementations described and claimed herein provide systems and methods systems and methods for managing network health, including alarm reduction in a subnetwork. In one implementation, an alarm list is received. The alarm list has alarm data captured from a plurality of remote nodes and consolidated at an aggregator node. A first alarm corresponding to an optical interface deployed in a circuit of a telecommunications subnetwork is identified from the alarm list. A topology associated with the optical interface is discovered by traversing a path of the circuit. An interface list is generated based on the topology. One or more alarms related to a root cause of the first alarm are identified based on a comparison of the interface list to the alarm list. The related alarms are correlated to the first alarm for concurrent resolution.

Abstract: Implementations described and claimed herein provide systems and methods systems and methods for managing network health, including optimizing a network. In one implementation, an alarm list for a subnetwork of a telecommunucations network is obtained. The alarm list has alarm data captured from a plurality of network elements forming the subnetwork. Network data associated with a subset of the network elements is captured by traversing a circuit path in the subnetwork from a source to a destination. The subset of network elements disposed is along the circuit path. The alarm list is correlated with the network data to identify a related network issue. A root cause of the related network issue is determined. One or more recommendations for resolving the root cause of the related network issue are generated, and at least one of the recommendations is deployed in the subnetwork.

Abstract: Various systems and methods for caching and tiering in cloud storage are described herein. A system for managing storage allocation comprises a storage device management system to maintain an access history of a plurality of storage blocks of solid state drives (SSDs) managed by the storage device management system; and automatically configure each of a plurality of storage blocks to operate in cache mode or tier mode, wherein a ratio of storage blocks operating in cache mode and storage blocks operating in tier mode is based on the access history.

Abstract: One aspect of the present disclosure relates to a therapy delivery device for treating an obstetric or gynecological disorder other than urinary incontinence in a subject. The therapy delivery device can include a housing, at least one electrode, and a power source. The housing can be configured for implantation in a reproductive system of the subject. The at least one electrode can be connected to the housing and be configured to delivery an electrical signal to an autonomic nervous system nerve target. The power source can be in electrical communication with the at least one electrode.