Abstract: The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.

Abstract: Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.

Abstract: The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.

Abstract: The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.

Abstract: The present invention relates to single dose parenteral vaccine compositions comprising mixtures of monovalent Norovirus virus-like particles. Methods of conferring protective immunity against Norovirus infections in a human subject by administering such compositions are also disclosed.

Abstract: Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.

Abstract: The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.

Abstract: The present invention provides systems and methods for monitoring a heart. According to one embodiment, the system includes an implantable registering unit for registering an electrical signal from the heart. The system includes a local data unit in operable communication with registering unit. The local data unit may be placed in communication with a computer, which may be at a location remote from the local data unit. The computer is adapted to receive the data from the local data unit corresponding to the registered electrical signal and to compare the registered electrical signal to a reference electrical signal to determine whether the heart is functioning properly.

Abstract: A method of notifying an intermediary located remote from a user of an emergency service requested by the user associated with a mobile communication device includes receiving, at the intermediary, an alarm signal generated by a user interaction with a safety application on the mobile communication device. Upon receipt, an audio communication link or a video communication link is activated between the mobile communication device and the intermediary based on the user's interaction with the safety application. Information, such as static personal user information and dynamic location information of the mobile communication device, is presented to the intermediary. The intermediary may then contact a third party based on a communication between the user and the intermediary and a location of the mobile communication device.

Abstract: A flying disc includes a hub composed of polymeric material, a ring composed of polymeric material and coupled to the hub. The hub and the ring may have different specific gravities by being composed of different materials or by having a weighting product embedded therein, or a weighting product may be carried between the hub and the ring.

Abstract: The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.

Abstract: The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.

Abstract: The present invention is directed to methods for analyzing electrical signals generated by biological tissues, such as muscles (e.g., cardiac or skeletal muscle) and tissue within the nervous system (e.g., neurons within the central and peripheral nervous systems). The tissue may be a patient's own, or it may have been transplanted into the patient from a donor organism or from a tissue or cell culture. The result of the analysis indicates the condition of the tissue, and results obtained over time can alert a patient or health care professional to changes in that condition.

Abstract: A method, device, and computer program product for Session Initiation Protocol (SIP) communications is disclosed. The method, device, and computer program product allow a SIP user agent of a SIP-enabled device to register with a plurality of SIP registrars. The plurality of SIP registration may occur simultaneously or sequentially, based on preference information for the SIP registrars.

Abstract: A debris collection device comprising: a graduated columnar member having, a first open end located in a top rim, a second open end located in a bottom rim, an inner surface, and an outer surface. First open end and second open end of the graduated columnar member oppose each other to form a through-hole between the top rim and the bottom rim defined by the inner surface having an inner volume of the graduated columnar member (creating a funnel profile.) The outer surface may comprise a flat portion such that the debris collection device can be laid in a debris collection orientation on a ground surface (parallel to) suitable to convey refuse from the ground surface into the top rim, though the graduated columnar member, and into a flexible bag removably-coupled to the bag holding periphery of the bottom rim to storably-contain said refuse for transport to another location.

Abstract: The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.

Abstract: The present invention relates to vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to methods of conferring protective immunity to Norovirus infections in a human subject.

Abstract: The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.

Abstract: The present invention relates to vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to methods of conferring protective immunity to Norovirus infections in a human subject.

Abstract: Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.