Abstract: Methods are described for applying braze filler material onto a component part interface having a uniform thickness regardless of the interface contour using cold spray deposition technology.

Abstract: A denture attachment system (10) comprises an implant member (12) adapted to be secured in a mandible (B) such that a head (20) of the implant member (12) projects out of the mandible (B). A locking mechanism (14) is adapted to be received in a denture (A) so as to cooperate with the implant member (12) to releasably secure the denture (A) to the implant member (12). The locking mechanism (14) has a receptacle (50,51) for receiving the head (20) of the implant member (12).

Abstract: For determining the behavior of a flexible system submitted to predetermined displacement boundary conditions, a process uses geometrically non-linear finite element analysis. The process has a plurality of incremental steps within a total Lagrangian formalism with co-rotational update. In each incremental step, one computes for a finite element of the flexible system a displacement vector, having translational and rotational components, at the nodes of the finite element. This computation of the displacement vector is carried out by minimizing the energy of the flexible system when the system is submitted to a fraction of the predetermined displacement. For a given finite element, the co-rotational update is carried out by computing an updated elementary frame of reference, without considering the bending rotational components of the displacement vectors computed at the nodes of the finite element. The properties of this co-rotational update make all computations similar, hence simpler and easier.

Abstract: A process of using finite element analysis for determining the behaviour of a system, submitted to predetermined load and displacement boundary conditions with a degree of freedom relative to a local coordinate system released at one node of the system. For a geometrically non-linear solution scheme, a plurality of incremental steps are carried, for which computing for a finite element of the system a displacement vector at the nodes of the finite element is performed by minimizing the energy of the system. For a geometrically linear solution scheme, a single solving step is carried, for which similar steps of computing for a finite element and timely minimizing of the system's energy are performed. The step of minimizing is carried out, for a node having a released degree of freedom, in a local frame of reference, and the released degree of freedom at the node is expressed along one axis of such frame.

Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.

Abstract: Methods of treating migraine comprising conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides are disclosed. The compounds of the present invention of Formula I have valuable pharmacological properties based on their ability to selectively antagonize calcitonin gene-related peptide (CGRP) receptor for acute and prophylactic treatment of headaches, particularly migraines.

Abstract: The invention concerns coated particles based on granulated microcrystals of ibuprofen, its pharmaceutically acceptable isomers and salts, characterized in that they comprise a coating obtained in a fluidized bed apparatus with a hydroalcoholic dispersion consisting of a mixture comprising (A) 5 to 50% by weight of ethylcellulose relative to ibuprofen; (B) 10 to 60% by weight of hydroxypeopylmethylcellulose relative to the ethylcellulose; and (C) 1 to 40% by weight of silica with antistatic and permeabilizing properties relative to the ethylcellulose, the resulting coating, whereof at least one of the constituents can be used for granulating the ibuprofen microcrystals resulting in said particles, thereby masking the unpleasant taste of ibuprofen and significantly reducing its irritating effect on the throat after deglutition and substantially immediate release of ibuprofen when the particles are placed in an aqueous medium.

Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides are disclosed. The compounds of the present invention of Formula I have valuable pharmacological properties based on their ability to selectively antagonize calcitonin gene-related peptide (CGRP) receptor for acute and prophylactic treatment of headaches, particularly migraines.

Abstract: The present invention relates to novel heterocyclic compounds, according to Formula I, that stimulate endogenous production and/or release of growth hormone, wherein R1, R2, R3, R4 and X are defined herein. Further, the present invention relates to methods for using such compounds and to pharmaceutical compositions containing such compounds.

Abstract: A system, apparatus and method is disclosed for providing a consistent liquid mixture according to a predetermined recipe for use at a point of use. The apparatus includes a plurality of liquid component reservoirs in which a constant gas pressure is maintained. A plurality of valves are provided, with individual valves connected to an outlet port of each reservoir. An electronic controller controls the valve actuation in a repetitive sequence to discharge predetermined doses of selected liquid components for mixing to form the consistent liquid mixture. A mixing section receives the sequence of doses to mix them together to form the liquid mixture.

Abstract: A method and system is described for estimating stress characteristics from seismic data. The method includes receiving seismic data acquired over a region, receiving properties of rock at a location within the region, and estimating one or more stress characteristics for a sub-region by combining the seismic data and the rock properties using a relationship between the stress characteristics in the sub-region and elastic stiffness and/or sonic velocity in the sub-region. The relationship is based on a non-linear elasticity theory.

Abstract: the expandable screen door comprises of a minimum of two and up to an unlimited amount of screen sections (18, 19,20 & 15,16,17). Each with either a hook or loop, or magnet, or other fastener attached to one side of the top of the screen (12) (8), and the opposite or attracting hook, loop or other fastener, attached on the opposite top side of the screen (14) (9). The middle part of each screen section (7) consists of a flexible ventilating screen or netting material. A flexible and heavier piece of material that can be folded, rolled up or cut, is attached to the bottom part of the screen (10).

Abstract: A system, apparatus and method is disclosed for providing a consistent liquid mixture according to a predetermined recipe for use at a point of use. The apparatus includes a plurality of liquid component reservoirs in which a constant gas pressure is maintained. A plurality of valves are provided, with individual valves connected to an outlet port of each reservoir. An electronic controller controls the valve actuation in a repetitive sequence to discharge predetermined doses of selected liquid components for mixing to form the consistent liquid mixture. A mixing section receives the sequence of doses to mix them together to form the liquid mixture.

Abstract: A system, apparatus and method is disclosed for providing a consistent liquid mixture according to a predetermined recipe for use at a point of use. The apparatus includes a plurality of liquid component reservoirs in which a constant gas pressure is maintained. A plurality of valves are provided, with individual valves connected to an outlet port of each reservoir. An electronic controller controls the valve actuation in a repetitive sequence to discharge predetermined doses of selected liquid components for mixing to form the consistent liquid mixture. A mixing section receives the sequence of doses to mix them together to form the liquid mixture.

Abstract: A method and system is described for estimating stress characteristics from seismic data. The method includes receiving seismic data acquired over a region, receiving properties of rock at a location within the region, and estimating one or more stress characteristics for a sub-region by combining the seismic data and the rock properties using a relationship between the stress characteristics in the sub-region and elastic stiffness and/or sonic velocity in the sub-region. The relationship is based on a non-linear elasticity theory.

Abstract: A system, apparatus and method is disclosed for providing a consistent liquid mixture according to a predetermined recipe for use at a point of use. The apparatus includes a plurality of liquid component reservoirs in which a constant gas pressure is maintained. A plurality of valves are provided, with individual valves connected to an outlet port of each reservoir. An electronic controller controls the valve actuation in a repetitive sequence to discharge predetermined doses of selected liquid components for mixing to form the consistent liquid mixture. A mixing section receives the sequence of doses to mix them together to form the liquid mixture.

Abstract: Cloning systems useful for the isolation of recombinant nucleic acid are disclosed in which the recombination of cloning-system nucleic acid and foreign nucleic acid is linked to the expression of a moiety on the surface of a host organism, the moiety being a first member of a binding pair. When recombination occurs between the nucleic acid and the foreign nucleic acid, the moiety is expressed on the surface of the host organism. The isolation of recombinant nucleic acid is then performed by attaching a second member of the binding pair to a solid support and contacting the host organism with the support. When the first member of the binding pair is expressed on the surface of the host organism, the host organism binds to the second member of the binding pair attached to the solid support, thereby selectively isolating those organisms. Other aspects of the invention include devices for the isolation of individual cells that differentially express binding moieties on their surface.

Abstract: A movable permanent magnet (38) is moved by a rotating rig (29, 30) driven by a spiral thermometer (27). This magnet is designed to activate an interrupter (43) of an electric circuit housed in a sonic detecting-warning device (44) capable of rotating on the periphery of a housing 11. The circuit also comprises a battery (45) and a buzzer (46). When the magnet (38) rotates past the interrupter (43) it causes the interrupter to close, thereby actuating the buzzer (46). The angular position of the detector (44) is selected according to the temperature at which the warning signal is to be given.

Abstract: A rotary device driven by a moving fluid, such as water or air, for generating a rotary movement comprises a cylindrical or frusto-conical rotor having a vertical axis, the rotor having a plurality of identical blades distributed around the periphery of the rotor, each blade having a symmetrical aerodynamic profile and being mounted so as to freely rotate about a substantially vertical axis parallel to its leading edge. The device may be used to power a screw driven boat, a wheeled vehicle or other machinery.