Abstract: A catheter having an imaging device on its distal end serves as a guidewire for cannula tools, enabling the tools to be advanced to a desired site in a patient's body. One exemplary embodiment of such a catheter is a scanning fiber endoscope. The images facilitate navigation through linked body lumens and also enable an operator to view a site where a biopsy sample is to be taken with a cannula tool. Exemplary cannula tools include bristles or sharp points that scrub cells from adjacent tissue, a biopsy needle that can be thrust into tissue, a loop that cuts away tissue, a cutting edge that slices tissue from a site, and forceps. The sample can be carried by a bodily or introduced fluid to a proximal end of the catheter through an annular gap between the catheter and the cannula tool, or the cannula tool can retain the sample.

Abstract: A method of one aspect may include actuating a cantilevered optical fiber by mechanically deforming a piezoelectric actuator. An electrical signal generated as a result of mechanical deformation of the piezoelectric actuator may also be detected.

Abstract: A flexible endoscope includes an elongate flexible extrusion. A central lumen extends longitudinally through the center of the extrusion, and a plurality of other longitudinally extending lumens are spaced around the central lumen. An optical fiber is inserted within the central lumen and is coupled to its inner surface. This optical fiber serves as a compression member and conveys light through the flexible endoscope. A first pair of tension members extend through lumens on opposite sides of the central lumen. Applying a tension force to one of these tension members causes a distal tip of the flexible endoscope to bend in a first direction, while applying a tension force to the opposite tension member causes the distal tip to bend in an opposite direction. Providing a second pair of tension members in lumens disposed orthogonal to the first pair enables bending of the distal tip relative to orthogonal axes.

Abstract: A system includes a plurality of scanning devices and light receivers, enabling a plurality of images of a site to be displayed using output signals produced in response to light from the light receivers. To avoid crosstalk caused by light receivers receiving light emitted by a plurality of scanning devices, different wavebands of light can be applied to different scanning devices, the received light can be filtered, or the light can be supplied to one scanning device at a time to multiplex either frame-by-frame, or pixel-by-pixel, or the light supplied to each scanning device can be modulated and the received light demodulated so that an image is produced in response to light from a single scanning device. Expensive components such as laser light sources, optical detectors, a controller, and processor can be shared by multiple imaging devices to minimize the cost of the imaging system.

Abstract: A scanning fiber device of one aspect may include an actuator tube. An optical fiber may be inserted through the actuator tube. The optical fiber may have a free end portion outside of the actuator tube. A first bead may be around the optical fiber. At least part of the first bead may be within a distal portion of the actuator tube. An adhesive may be adhering the first bead to the distal portion of the actuator tube. A second bead may be around the optical fiber. At least part of the second bead may be within a proximal portion of the actuator tube. An adhesive may be adhering the second bead to the proximal portion of the actuator tube.

Abstract: Scanning beam devices are disclosed. In one aspect, an apparatus may include a housing having a transparent portion. A scanning optical element may be enclosed within the housing. Light may be directed between the scanning optical element and the transparent portion of the housing. The device may include a temperature adjustment device to adjust a temperature within the housing. Methods of using such apparatus are also disclosed, as are base stations to control the adjustment of the temperature.

Abstract: Scanning fiber devices are disclosed. In one aspect, a scanning fiber device may include an actuator tube. The scanning fiber device may also include a cantilevered free end portion of an optical fiber. The cantilevered free end portion of the optical fiber may have an attached end that is coupled with the actuator tube. The cantilevered free end portion of the optical fiber may also have a free end to be moved by the actuator tube. At least a portion of a length of the cantilevered free end portion of the optical fiber may be disposed within the actuator tube. Methods of using scanning fiber devices are also disclosed.

Abstract: A system includes a plurality of scanning devices and light receivers, enabling a plurality of images of a site to be displayed using output signals produced in response to light from the light receivers. To avoid crosstalk caused by light receivers receiving light emitted by a plurality of scanning devices, different wavebands of light can be applied to different scanning devices, the received light can be filtered, or the light can be supplied to one scanning device at a time to multiplex either frame-by-frame, or pixel-by-pixel, or the light supplied to each scanning device can be modulated and the received light demodulated so that an image is produced in response to light from a single scanning device. Expensive components such as laser light sources, optical detectors, a controller, and processor can be shared by multiple imaging devices to minimize the cost of the imaging system.

Abstract: A scanning fiber device of one aspect may include an actuator tube. An optical fiber may be inserted through the actuator tube. The optical fiber may have a free end portion outside of the actuator tube. A first bead may be around the optical fiber. At least part of the first bead may be within a distal portion of the actuator tube. An adhesive may be adhering the first bead to the distal portion of the actuator tube. A second bead may be around the optical fiber. At least part of the second bead may be within a proximal portion of the actuator tube. An adhesive may be adhering the second bead to the proximal portion of the actuator tube.

Abstract: Methods of reducing distortion in scanning fiber devices are disclosed. In one aspect, a method includes changing an intensity of light transmitted through a cantilevered optical fiber of a scanning fiber device. The method also includes changing a setpoint temperature for the scanning fiber device based at least in part on the change in the intensity of the light. Other methods, apparatus, systems, and machine-readable mediums are also disclosed.

Abstract: Methods of reducing distortion in scanning fiber devices are disclosed. In one aspect, a method includes changing an intensity of light transmitted through a cantilevered optical fiber of a scanning fiber device. The method also includes changing a setpoint temperature for the scanning fiber device based at least in part on the change in the intensity of the light. Other methods, apparatus, systems, and machine-readable mediums are also disclosed.

Abstract: A method of one aspect may include actuating a cantilevered optical fiber by mechanically deforming a piezoelectric actuator. An electrical signal generated as a result of mechanical deformation of the piezoelectric actuator may also be detected.

Abstract: A multi-cladding optical fiber includes a core that conveys visible light used by a scanner for imaging a site within a patient's body, and an inner cladding that conveys high-power light, such as infrared light, used for providing therapy to site. The distal end of multi-cladding optical fiber is driven to scan the site when imaging or rendering therapy using an actuator. High-power light is coupled into inner cladding at proximal end of optical fiber using several different techniques. Some techniques use an axicon to direct the high-power light into the inner cladding, while visible light is coupled directly into the core. Another technique uses a multimode optical fiber in a coupling relationship with the multi-cladding optical fiber, to transfer high-power light from a core of the multimode fiber into the inner cladding of the multi-cladding optical fiber.

Abstract: Methods of attaching optical fibers to actuator tubes in the manufacture of scanning fiber devices are disclosed. In one aspect, a method may include applying a bead to an optical fiber of a scanning fiber device near a proximal end of a free end portion of the optical fiber. Then, the bead may be adhered at least partially within an actuator tube of the scanning fiber device by applying and curing an adhesive. Scanning fiber devices manufactured by such methods are also disclosed.

Abstract: Scanning fiber devices are disclosed. In one aspect, a scanning fiber device may include an actuator tube. The scanning fiber device may also include a cantilevered free end portion of an optical fiber. The cantilevered free end portion of the optical fiber may have an attached end that is coupled with the actuator tube. The cantilevered free end portion of the optical fiber may also have a free end to be moved by the actuator tube. At least a portion of a length of the cantilevered free end portion of the optical fiber may be disposed within the actuator tube. Methods of using scanning fiber devices are also disclosed.

Abstract: Different exemplary embodiments of cannula tools each perform multiple functions. Each cannula tool is able to dislodge or cut away a biopsy sample from a desired site within a patient's body, and then collect the sample. The cannula tool, which is disposed at the distal end of an elongate flexible tube is guided to the desired site over a guide wire. The cannula tool either abrades cells from adjacent tissue with an abrasive surface, or cuts away a sample of tissue with a sharpened cutting edge or with a loop that is electrically heated or pulled to snare the sample. The biopsy sample is then drawn with a bodily fluid or introduced fluid through an annulus formed between the guide wire and the inner surface of the elongate flexible tube or through a lumen, for collection at the proximal end of the elongate flexible tube.

Abstract: A catheter having an imaging device on its distal end serves as a guidewire for cannula tools, enabling the tools to be advanced to a desired site in a patient's body. One exemplary embodiment of such a catheter is a scanning fiber endoscope. The images facilitate navigation through linked body lumens and also enable an operator to view a site where a biopsy sample is to be taken with a cannula tool. Exemplary cannula tools include bristles or sharp points that scrub cells from adjacent tissue, a biopsy needle that can be thrust into tissue, a loop that cuts away tissue, a cutting edge that slices tissue from a site, and forceps. The sample can be carried by a bodily or introduced fluid to a proximal end of the catheter through an annular gap between the catheter and the cannula tool, or the cannula tool can retain the sample.

Abstract: An optical fiber conveys light from a source at a proximal end, to a distal end, where a piezoelectric material tube applies a force that causes the distal end of the optical fiber to scan in a desired pattern. Light from the distal end of the optical fiber passes through a lens system and is at least partially reflected by a reflective surface toward a side of the scope, to illuminate tissue within a patient's body. Light received from the internal tissue is reflected back either to collection optical fibers, which convey the light to proximally disposed optical detectors, or directly toward distal optical detectors. The optical detectors produce electrical signals indicative of an intensity of the light that can be used for producing an image of the internal tissue. The light received from the tissue can be either scattered, polarized, fluorescent, or filtered, depending on the illumination light.

Abstract: Methods and system for counterbalancing accelerations and/or torques caused by actuation of an actuation element and a scanning element. A scanning beam device may comprise a counterbalance to generate forces and/or torques that are substantially equal and substantially opposite to the forces and/or torque generated by the scanning of the actuation element.

Abstract: Methods of attaching optical fibers to actuator tubes in the manufacture of scanning fiber devices are disclosed. In one aspect, a method may include applying a bead to an optical fiber of a scanning fiber device near a proximal end of a free end portion of the optical fiber. Then, the bead may be adhered at least partially within an actuator tube of the scanning fiber device by applying and curing an adhesive. Scanning fiber devices manufactured by such methods are also disclosed.