Patents by Inventor Charles K. Brush

Charles K. Brush has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorescein labelled phosphoramidites
    Patent number: 5371241
    Abstract: Compounds useful for attaching a fluorescein label to an oligonucleotide are disclosed. The compounds are fluorescein-linked phosphoramidites where the hydroxyl groups on the fluorescein moiety are protected by isobutyryl groups.
    Type: Grant
    Filed: July 19, 1991
    Date of Patent: December 6, 1994
    Assignee: Pharmacia P-L Biochemicals Inc.
    Inventor: Charles K. Brush
  • Intermediates for preparing 6-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4342686
    Abstract: The preparation and use as intermediates is described for 7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures are characterized by having either an aralkyl or lower alkanoyl group at position 2 or an .alpha.-hydroxyalkyl or .alpha.-chloroalkyl group at position 6.
    Type: Grant
    Filed: November 13, 1980
    Date of Patent: August 3, 1982
    Assignee: SmithKline Corporation
    Inventors: Charles K. Brush, Joseph Weinstock
  • 6-Lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4265889
    Abstract: A series of 6-lower alkyl-7,8-dihydroxyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having dopaminergic activity together with intermediates and processes for their preparation are disclosed.
    Type: Grant
    Filed: December 22, 1978
    Date of Patent: May 5, 1981
    Assignee: SmithKline Corporation
    Inventors: Charles K. Brush, Joseph Weinstock
  • 8-Hydro xy-6,7-(2-methyl-2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaz epines
    Patent number: 4255445
    Abstract: 8-Hydroxy-6,7-(2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin es are prepared by a reaction sequence whose key is a dual cyclization forming the 3-benzazepine ring and fused thereto a dihydrofuran.
    Type: Grant
    Filed: March 7, 1980
    Date of Patent: March 10, 1981
    Assignee: SmithKline Corporation
    Inventors: Charles K. Brush, Joseph Weinstock
  • 4-(2-Aminoethyl)-7-hydroxy-2-methyl-2,3-dihydrobenzofurans
    Patent number: 4254140
    Abstract: 4-(2-Aminoethyl)-7-hydroxy-2-methyl-2,3-dihydrobenzofuran derivatives having dopaminergic activity are prepared by cyclizing a 2-allyl-3,4-dimethoxyphenethylamine such as by reacting the phenethylamine with hydrogen bromide.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: March 3, 1981
    Assignee: SmithKline Corporation
    Inventors: Charles K. Brush, Joseph Weinstock
  • 6-Carboxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds and use as dopaminergic agents
    Patent number: 4165372
    Abstract: A group of 1-phenyl-3-benzazepines with structures characterized by having a carboxy derived substituent at position 6 which are dopaminergic agents or are intermediates for preparing other dopaminergic agents. Particular illustrative species include 6-carbomethoxy-7,8-dihydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-ben zazepine, 6-carboxy-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 6-carbomethoxy-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3- benzazepine.
    Type: Grant
    Filed: November 17, 1977
    Date of Patent: August 21, 1979
    Assignee: SmithKline Corporation
    Inventors: Charles K. Brush, Joseph Weinstock
  • Substituted benzofurans and benzothiophenes
    Patent number: 4001426
    Abstract: The compounds are benzoyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris and intermediates for the preparation thereof.
    Type: Grant
    Filed: May 9, 1975
    Date of Patent: January 4, 1977
    Assignee: SmithKline Corporation
    Inventors: L. Martin Brenner, Charles K. Brush
  • Benzophenalenofurans
    Patent number: 3985896
    Abstract: The compounds are benzophenalenofurans having pharmacological activity, in particular, coronary vasodilator activity.
    Type: Grant
    Filed: July 15, 1975
    Date of Patent: October 12, 1976
    Assignee: SmithKline Corporation
    Inventors: L. Martin Brenner, Charles K. Brush
  • Process for the preparation of aromatic aldehydes
    Patent number: 3946067
    Abstract: A process is described for the preparation of aromatic aldehydes such as benzaldehyde or substituted benzaldehydes involving the vapor phase oxidation of aralkyl compounds such as toluene or substituted toluenes, respectively, at temperatures of less than about 250.degree.C. in the presence of a catalyst composition containing phosphoric acid and a catalytically effective amount of palladium metal. The aromatic aldehydes are produced in a single reaction step.
    Type: Grant
    Filed: January 28, 1975
    Date of Patent: March 23, 1976
    Assignee: National Distillers and Chemical Corporation
    Inventors: Jack Kwiatek, Jawad H. Murib, Charles K. Brush