Abstract: Various methods and devices are provided for allowing multiple surgical instruments to be inserted into sealing elements of a single surgical access device. The sealing elements can be movable along predefined pathways within the device to allow surgical instruments inserted through the sealing elements to be moved laterally, rotationally, angularly, and vertically relative to a central longitudinal axis of the device for ease of manipulation within a patient's body while maintaining insufflation.

Abstract: Described herein are systems and methods of flow-through electroporation can comprise a chamber with a first and a second portion, wherein the first portion is configured to receive cells and the second portion is in fluid communication with the first portion and is configured to receive cells from the first portion; an electrode can be present in the first portion, second portion, or both; a porous membrane can separate the first and second portions, the porous membrane can have one or more pores, and the pores can have one or more interior surfaces configured to allow cells from the first portion to pass through to the second portion; an electric generating device in electrical communication with one or more electrodes, the membrane, or the one or more electrodes and the membrane, wherein the electric generating device is configured to deliver constant voltage or one or more electric pulses to the system.

Abstract: Described herein is an additive manufacturing apparatus that is well-suited for constructing piezoelectric sensors. The additive manufacturing apparatus includes an extrusion nozzle formed of a conductive material such as aluminum. The extrusion nozzle has a channel by way of which printing material exits the extrusion nozzle, wherein a build plate is configured to receive the printing material responsive to the printing material exiting the extrusion nozzle. An arc suppressor formed of a semiconductor is coupled to the extrusion nozzle and is configured to dissipate excess charge that would otherwise exist on the extrusion nozzle when a relatively high bias voltage is applied to the extrusion nozzle. Thus, the arc suppressor mitigates arcing between the extrusion nozzle and the build plate. Arc suppressing gas is also optionally introduced into a printing region, thereby further mitigating arcing between the extrusion nozzle and the build plate.

Abstract: Described herein are systems and methods of flow-through electroporation can comprise a chamber with a first and a second portion, wherein the first portion is configured to receive cells and the second portion is in fluid communication with the first portion and is configured to receive cells from the first portion; an electrode can be present in the first portion, second portion, or both; a porous membrane can separate the first and second portions, the porous membrane can have one or more pores, and the pores can have one or more interior surfaces configured to allow cells from the first portion to pass through to the second portion; an electric generating device in electrical communication with one or more electrodes, the membrane, or the one or more electrodes and the membrane, wherein the electric generating device is configured to deliver constant voltage or one or more electric pulses to the system.

Abstract: Systems and methods of operating a computing system may involve receiving, at a control interface, an instruction to alter a power state at a memory device, and directing, by the control interface, a controller to control a power supply to a memory device channel to alter the power state in the memory device.

Abstract: Systems and methods of operating a computing system may involve receiving, at a control interface, an instruction to alter a power state at a memory device, and directing, by the control interface, a controller to control a power supply to a memory device channel to alter the power state in the memory device.

Abstract: Systems and methods of operating a computing system may involve receiving, at a control interface, an instruction to alter a power state at a memory device, and directing, by the control interface, a controller to control a power supply to a memory device channel to alter the power state in the memory device.

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making nanostructures (e.g., nanoparticles, nanofibers), systems for making nanostructures, and the like.

Abstract: An active membrane creates a secure area around one or more devices. The active membrane forms a physical barrier between the encased secure area and an external environment. Linked to the membrane and acting as the sole interface between the secure area and the outside environment is a boundary interface. The boundary interface tunnels data to the secure area in a secure fashion. According to one embodiment of the present invention, the boundary interface utilizes symmetric and/or asymmetric cryptographic techniques to secure the data path. The boundary interface is also coupled to the active membrane, and upon the membrane sensing a breach of the membrane (thus signifying an intrusion of the secure area), the boundary interface can be configured to sever the data paths linking the secure area with the unsecured area as well as take other active steps to ensure that data within the secure area is not compromised.

Abstract: A method of forming DNA nanotubes composed entirely or predominantly from DNA that, The methods of the present invention form single layer or multilayer template-synthesized nanotubes where the bulk of the tube is composed of DNA, and the layers are held together by hybridization of complementary DNA strands. The DNA molecules making up these tubes may be varied as desired, and the DNA is capable of being released from the tube.

Abstract: The state of a computing environment is captured and heterogeneously stored on a network using self-organizing data portions. Altered portions of data of a captured computing state are replicated a plurality of times and each are embedded with a rule set that governs the distribution of the data. The rule set of each portion directs that data portion to relocate itself and remain as distant as possible from other replicated copies of that particular captured state and stored on a heterogeneous storage medium. Simultaneously, data portions that are associated with a similar file or other data structure are directed to maintain proximity with each other within a replicated copy forming a self-organized distribution of data portions.

Abstract: The present invention relates to an apparatus having a nanodevice (1) for controlling the flow of charged particles in an electrolyte. Such apparatus comprises an electrolytic bath container (2) divided by a polymeric membrane foil (3) into a first (4) and a second compartment (5), wherein each compartment (4, 5) comprises an electrode (6, 7) connected to a voltage supply (8). Further the apparatus comprises at least one asymmetric pore (9) forming a via hole through said foil (3), wherein said pore (9) provides a narrow opening (10) of a diameter in the range of several nanometers down to about one nanometer on a front side (11) of said foil (3) and a wide opening (12) in the range of several ten nanometers up to several hundred nanometers on a back side (13) of said foil (3).

Abstract: A method of forming DNA nanotubes composed entirely or predominantly from DNA that, The methods of the present invention form single layer or multilayer template-synthesized nanotubes where the bulk of the tube is composed of DNA, and the layers are held together by hybridization of complementary DNA strands. The DNA molecules making up these tubes may be varied as desired, and the DNA is capable of being released from the tube.

Abstract: Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

Abstract: Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

Abstract: A method of removing a toxic compound comprising contacting the toxic compound with a particle having two regions, the first region containing a detoxifying enzyme and the second region containing a material selected to partition the toxic compound into the second region. The particle may be a nanoparticle.

Abstract: An active membrane creates a secure area around one or more devices. The active membrane forms a physical barrier between the encased secure area and an external environment. Linked to the membrane and acting as the sole interface between the secure area and the outside environment is a boundary interface. The boundary interface tunnels data to the secure area in a secure fashion. According to one embodiment of the present invention, the boundary interface utilizes symmetric and/or asymmetric cryptographic techniques to secure the data path. The boundary interface is also coupled to the active membrane, and upon the membrane sensing a breach of the membrane (thus signifying an intrusion of the secure area), the boundary interface can be configured to sever the data paths linking the secure area with the unsecured area as well as take other active steps to ensure that data within the secure area is not compromised.

Abstract: A method of securely storing a data item including obtaining the data item; translating the data item into a first plurality of data blocks using an erasure code associated with a rate; and storing at least a subset of the first plurality of data blocks, where a size of the subset exceeds a product of the rate and a size of the first plurality of data blocks.

Abstract: The state of a computing environment is captured and heterogeneously stored on a network using self-organizing data portions. Altered portions of data of a captured computing state are replicated a plurality of times and each are embedded with a rule set that governs the distribution of the data. The rule set of each portion directs that data portion to relocate itself and remain as distant as possible from other replicated copies of that particular captured state and stored on a heterogeneous storage medium. Simultaneously, data portions that are associated with a similar file or other data structure are directed to maintain proximity with each other within a replicated copy forming a self-organized distribution of data portions.

Abstract: The invention relates to the nanotubes of various sizes and composed of a wide variety of materials, or combination of materials. The invention also describes the use of such nanotubes for the delivery of various payloads and, in particular, for the in vivo delivery of bioactive substances.