Abstract: Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

Abstract: A particle with two regions, the first region contains a detoxifying enzyme and a second region that partitions toxic compounds. The particle may be a nanoparticle.

Abstract: The invention relates to the nanotubes of various sizes and composed of a wide variety of materials, or combination of materials. The invention also describes the use of such nanotubes for the delivery of various payloads and, in particular, for the in vivo delivery of bioactive substances.

Abstract: The present invention relates to an apparatus having a nanodevice for controlling the flow of charged particles in an electrolyte. Such apparatus comprises an electrolytic bath container divided by a polymeric foil into a first and a second compartment, wherein each compartment comprises an electrode connected to a voltage supply. Further the apparatus comprises at least one asymmetric pore forming a via hole through said foil, wherein said pore provides a narrow opening of a diameter in the range of several nanometers down to about one nanometer on a front side of said foil and a wide opening in the range of several ten nanometers up to several hundred nanometers on a back side of said foil.

Abstract: Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

Abstract: The present invention relates to a sub-frame assembly for a truck body having a roll-up door, a radius top header formed with a radius on its lateral axis, an extruded top cross-piece, an extruded corner post formed with an integral door-track groove, an extruded bottom cross-piece, and an extruded bottom rail. The subframe assembly includes a structural top corner casting body which has a roll-up door track segment formed integrally with the top corner casting body, a top gusset stiffener plate formed integrally with the top corner casting body, and a radius top header edge formed integrally with the top corner casting body, the radius top header edge being formed to abut the radius top header at a juncture that will permit the radius top header to be lap-welded to the radius top header edge.

Abstract: A process is described for preparing 3-exomethylene cephalosporanic acid derivatives for use in the synthesis of cephalosporin antibiotics such as ceftibuten. The process comprises electrochemical reduction of a compound of the formula (IV) ##STR1## wherein: R.sup.3 is ##STR2## is an optional sulfoxide group; n is 2 or 3; R.sup.1 is H and R is H or NHR.sup.2, where R.sup.2 is H or a protecting group selected from C.sub.6 H.sub.5 CH.sub.2 OC(O)--, C.sub.6 H.sub.5 C(O)-- or C.sub.1 -C.sub.6 alkoxy-C(O)--; or wherein R and R.sup.1 together with the carbon atom to which they are attached comprise --C(O)--, and produces the desired 3-exomethylene compounds with low levels of the corresponding 3-methyl tautomers.

Abstract: A process is described for preparing 3-exomethylene cephalosporanic acid derivatives for use in the synthesis of cephalosporin antibiotics such as ceftibuten. The process comprises electrochemical reduction of a compound of the formula (IV) ##STR1## wherein: R.sup.3 is CH.sub.3 C(O)--; ##STR2## is an optional sulfoxide group; n is 2 or 3; R.sup.1 is H and R is H or NHR.sup.2, where R.sup.2 is H or a protecting group selected from C.sub.6 H.sub.5 CH.sub.2 OC(O)--, C.sub.6 H.sub.5 C(O)-- or C.sub.1 -C.sub.6 alkoxy-C(O)--; or wherein R and R.sup.1 together with the carbon atom to which they are attached comprise --C(O)--, and produces the desired 3-exomethylene compounds with low levels of the corresponding 3-methyl tautomers.

Abstract: A process is described for preparing 3-exomethylene cephalosporanic acid derivatives for use in the synthesis of cephalosporin antibiotics such as ceftibuten. The process comprises electrochemical reduction of a compound of the formula (IV) ##STR1## wherein: R.sup.3 is CH.sub.3 C(O)--; ##STR2## is an optional sulfoxide group; n is 2 or 3; R.sup.1 is H and R is H or NHR.sup.2, where R.sup.2 is H or a protecting group selected from C.sub.6 H.sub.5 CH.sub.2 OC(O)--, C.sub.6 H.sub.5 C(O)-- or C.sub.1 -C.sub.6 alkoxy--C(O)--; or wherein R and R.sup.1 together with the carbon atom to which they are attached comprise --C(O)--, and produces the desired 3-exomethylene compounds with low levels of the corresponding 3-methyl tautomers.

Abstract: A composite membrane suitable for separations of fluid components by electropolymerization of a discrimination layer on an electrically conductive porous support.

Abstract: An ultramicroelectrode assembly which generally comprises an electrically nonconducting host membrane having a plurality of micro-sized pores extending through the membrane, and a macro-sized substrate electrode in contact with this host membrane. The host membrane has its pores impregnated with an electrically conductive medium, and the substrate electrode is in electrical contact with the impregnated pores of the host membrane. The electrically conductive medium is a carbon paste, and the substrate electrode includes a confined volume of such carbon paste in contact with an interior surface of the impregnated membrane.

Abstract: A feeding device singulates, orients, and delivers seeds and other comparatively smooth-surfaced particulate material to a desired destination. The device comprises a horizontal rotating drum having an inner surface cut with a spiral groove for orienting ellipsoid-shaped particles and advancing them to the location of pickup orifices within the drum. A vacuum valve alternately subjects the orifices to vacuum and ambient pressure for picking up the individual particles and releasing them to the desired point of delivery.

Abstract: An automated grain characterization system includes grain crushing apparatus; a means for singulating kernels of grain and feeding them into the crushing apparatus; a means for measuring kernel size; a circuit for measuring kernel conductance; and a data acquisition and analysis subsystem for correlating crushing force, size, and conductivity to grain hardness. The output is a profile of the grain characteristics which can be compared to reference samples. This system is especially useful for grading and classifying wheat and predicting its end-use functional properties.

Abstract: The invention is a method for forming a perfluorosulfonate ionomer film comprising:(a) forming a solution of a perfluorosulfonate ionomer in its salt form;(b) coating a substrate with the perfluorosulfonate ionomer solution; and(c) heating the coated substrate to a temperature of at least about 120.degree. C. for sufficient time to deposit a solvent-resistant film of a perfluorosulfonate ionomer onto the substrate.

Abstract: Concentrations of large organic cationic species in aqueous solution are measured as a function of potentiometric response, employing a cation-selective electrode having a high degree of selectivity for large organic cationic species with respect to both smaller organic cationic species and inorganic cationic species. The electrode is formed with a cation-selective membrane component composed of a polymeric matrix having dispersed or dissolved therein a cation exchange material whose counter-anion is a high molecular weight alkyl or alkaryl sulfonate or sulphate. By proper choice of the cationic moiety of the cation exchange material, the electrode may be made selective for a variety of large organic cationic species, including a number of such species which are of pharmaceutical or clinical interest, thereby enabling potentiometric assays for such species.

Abstract: The servicing apparatus is mounted for running movement along, and for pivotal movement laterally of, a path of travel having a first section extending adjacent spinning units of the spinning machine and a second section extending adjacent an end cabinet of the spinning machine. During movement of the apparatus from the first and to the second section of its path of travel, it is pivoted laterally of such path to provide clearance between interfering components of the apparatus and the cabinet of the machine that would otherwise preclude movement of the apparatus along the second section of its path of travel. Pivotal movement of the apparatus is realized by a cam means so located as to not impede traffic adjacent the machine or access to the interior of its end cabinet, and as to minimize the magnitude of the force required to produce the aforesaid pivotal movement.

Abstract: During servicing of a spinning machine station by the piecing apparatus, the yarn positioning means establishes a generally U-shaped yarn line and brings the lowermost bight section of such line into desired association with the yarn delivery rolls at the spinning machine station. Rotatable members form the bight section of the yarn line and then transport the same, while the members occupy rotative positions effective to prevent lateral movement of the bight section, to a location closely adjacent the delivery rolls. The members then are rotated to other positions wherein they permit and guide lateral movement of the bight section toward a free end of one of the delivery rolls. When a piecing-aid device is present at the spinning machine station, the piecing apparatus includes a mechanism for imparting movement to a movable component of the device, and the positioning means of the apparatus includes means for associating parts of the U-shaped yarn line with the foregoing and other components of the device.

Abstract: A pneumatic tool for driving clamp nails, having a single nose piece making possible the driving of clamp nails into the outside corner of a miter joint, or the inside corner of a miter joint, and having a plate which may be adjusted to position the nose piece at any angle from 45.degree. to 30.degree. off the vertical centerline of the tool. When set at the 30.degree. angle, the nose piece is in the optimum position to drive a clamp nail into an inside right angled butt joint. A safety is provided having a configuration like the nose piece. The tool is provided with a magazine for a stick of clamp nails, and an adjustable rail in the magazine makes it adaptable to clamp nails of different sizes. The guide body through which the clamp nails are fed into position below the drive is provided with a configuration which makes it impossible to feed clamp nails if the stick is inserted into the magazine upside down.