Patents by Inventor Charles Reynolds

Charles Reynolds has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12138250
    Abstract: 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile, or a pharmaceutically acceptable salt, amorphous form, polymorph form, or pharmaceutical composition (including solid formulations or liquid formulations) thereof and the use thereof for treating diseases and disorders which can be treated with a RET kinase inhibitor, such as RET-associated diseases and disorders, e.g., proliferative disorders such as cancers, including hematological cancers and solid tumors, and gastrointestinal disorders such as IBS are disclosed.
    Type: Grant
    Filed: January 21, 2022
    Date of Patent: November 12, 2024
    Assignee: Loxo Oncology, Inc.
    Inventors: Mark Reynolds, Charles Todd Eary
  • Patent number: 12128068
    Abstract: The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.
    Type: Grant
    Filed: June 27, 2023
    Date of Patent: October 29, 2024
    Assignee: The University of Melbourne
    Inventor: Eric Charles Reynolds
  • Patent number: 12102621
    Abstract: 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile, or a pharmaceutically acceptable salt, amorphous form, polymorph form, or pharmaceutical composition (including solid formulations or liquid formulations) thereof and the use thereof for treating diseases and disorders which can be treated with a RET kinase inhibitor, such as RET-associated diseases and disorders, e.g., proliferative disorders such as cancers, including hematological cancers and solid tumors, and gastrointestinal disorders such as IBS are disclosed.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: October 1, 2024
    Assignee: Loxo Oncology, Inc.
    Inventors: Mark Reynolds, Charles Todd Eary
  • Publication number: 20240307573
    Abstract: A lighting fixture containing both visible light sources and UV light sources is disclosed herein. In one embodiment, the fixture is an overhead fixture. UV light can sanitize/disinfect the surrounding environment over a period of about 30-45 minutes. In this way, viruses, germs, bacteria, mold, and the like can be destroyed to clean the air and/or surfaces (e.g., furniture) of the room exposed to UV light. Accordingly, embodiments of the present invention include a physical input device, such as a wall-mounted button, switch, or wireless device, that can safely and efficiently activate a lighting assembly to produce UV light in a way that protects occupants from unintentional exposure to UV light. This configuration is especially useful in situations where the use of UV light is regulated, such as in a hospital setting.
    Type: Application
    Filed: May 24, 2024
    Publication date: September 19, 2024
    Inventors: Charles Reynolds, Mark Hiura
  • Patent number: 12011511
    Abstract: A lighting fixture containing both visible light sources and UV light sources is disclosed herein. In one embodiment, the fixture is an overhead fixture. UV light can sanitize/disinfect the surrounding environment over a period of about 30-45 minutes. In this way, viruses, germs, bacteria, mold, and the like can be destroyed to clean the air and/or surfaces (e.g., furniture) of the room exposed to UV light. Accordingly, embodiments of the present invention include a physical input device, such as a wall-mounted button, switch, or wireless device, that can safely and efficiently activate a lighting assembly to produce UV light in a way that protects occupants from unintentional exposure to UV light. This configuration is especially useful in situations where the use of UV light is regulated, such as in a hospital setting.
    Type: Grant
    Filed: April 25, 2023
    Date of Patent: June 18, 2024
    Assignee: CH Reynolds Electric Inc.
    Inventors: Charles Reynolds, Mark Hiura
  • Publication number: 20240033288
    Abstract: The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.
    Type: Application
    Filed: June 27, 2023
    Publication date: February 1, 2024
    Applicant: The University of Melbourne
    Inventor: Eric Charles Reynolds
  • Publication number: 20240016836
    Abstract: The present invention relates to compositions and their use for oral care. In particular, the compositions and methods are for maintaining oral health and/or treating various oral conditions such as gingivitis. The present invention relates to methods and uses of stabilized amorphous calcium phosphate (ACP) and/or stabilized amorphous calcium fluoride phosphate (ACFP) in the preparation of a medicament for reducing pathogenic oral bacteria at an oral site in an individual; increasing commensal oral bacteria at an oral site in an individual; decreasing the proportion of pathogenic oral bacteria at an oral site in an individual; inhibiting oral dysbiosis; reducing gingival inflammation in an individual in need thereof; treating gingivitis in an individual in need thereof; and treating chronic gingivitis in an individual in need thereof.
    Type: Application
    Filed: June 15, 2023
    Publication date: January 18, 2024
    Applicant: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Publication number: 20240000671
    Abstract: The present invention relates to compositions and methods for mineralizing a dental surface or subsurface including providing a composition including stabilized ACP and a source of fluoride ions.
    Type: Application
    Filed: November 3, 2022
    Publication date: January 4, 2024
    Applicant: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Publication number: 20230404867
    Abstract: The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.
    Type: Application
    Filed: January 4, 2023
    Publication date: December 21, 2023
    Applicant: The University of Melbourne
    Inventor: Eric Charles Reynolds
  • Publication number: 20230374081
    Abstract: The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.
    Type: Application
    Filed: January 9, 2023
    Publication date: November 23, 2023
    Applicant: ORAL HEALTH AUSTRALIA PTY LTD
    Inventors: Eric Charles REYNOLDS, Neil Martin O`BRIEN SIMPSON, Keith J. CROSS, Nada SLAKESKI
  • Publication number: 20230256125
    Abstract: A lighting fixture containing both visible light sources and UV light sources is disclosed herein. In one embodiment, the fixture is an overhead fixture. UV light can sanitize/disinfect the surrounding environment over a period of about 30-45 minutes. In this way, viruses, germs, bacteria, mold, and the like can be destroyed to clean the air and/or surfaces (e.g., furniture) of the room exposed to UV light. Accordingly, embodiments of the present invention include a physical input device, such as a wall-mounted button, switch, or wireless device, that can safely and efficiently activate a lighting assembly to produce UV light in a way that protects occupants from unintentional exposure to UV light. This configuration is especially useful in situations where the use of UV light is regulated, such as in a hospital setting.
    Type: Application
    Filed: April 25, 2023
    Publication date: August 17, 2023
    Inventors: Charles Reynolds, Mark Hiura
  • Patent number: 11717536
    Abstract: The present invention relates to compositions and their use for oral care. In particular, the compositions and methods are for maintaining oral health and/or treating various oral conditions such as gingivitis. The present invention relates to methods and uses of stabilized amorphous calcium phosphate (ACP) and/or stabilized amorphous calcium fluoride phosphate (ACFP) in the preparation of a medicament for reducing pathogenic oral bacteria at an oral site in an individual; increasing commensal oral bacteria at an oral site in an individual; decreasing the proportion of pathogenic oral bacteria at an oral site in an individual; inhibiting oral dysbiosis; reducing gingival inflammation in an individual in need thereof; treating gingivitis in an individual in need thereof; and treating chronic gingivitis in an individual in need thereof.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: August 8, 2023
    Assignee: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Patent number: 11717537
    Abstract: The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.
    Type: Grant
    Filed: June 3, 2022
    Date of Patent: August 8, 2023
    Assignee: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Patent number: 11649237
    Abstract: Provided herein, inter alia, are substituted imidazo[1,5-?]pyrazine compounds, compositions and methods for treating or preventing an IRE1?-related disease or disorder. In certain embodiments, the disease or disorder is selected from the group consisting of a neurodegenerative disease, a demyelinating disease, cancer, an eye disease, a fibrotic disease, and diabetes.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: May 16, 2023
    Assignees: Optikira LLC, The Regents of the University of California
    Inventors: Richard M. Keenan, Bradley J. Backes, Dustin J. Maly, Charles Reynolds, Ben Whittaker, Jamie Knight, Jonathan Mark Sutton, George Hynd, Feroz R. Papa, Scott A. Oakes
  • Patent number: 11572391
    Abstract: Disclosed are P. gingivalis antibodies raised against a chimeric or fusion protein, wherein the chimeric or fusion protein comprises a first peptide joined directly or through a linker to a second peptide or polypeptide, wherein (A) the first peptide comprises a region of a P. gingivalis trypsin-like enzyme and (B) the second peptide or polypeptide comprises an adhesin domain of P. gingivalis.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: February 7, 2023
    Assignee: Oral Health Australia PTY Ltd
    Inventors: Eric Charles Reynolds, Neil Martin O'Brien Simpson, Keith J. Cross, Nada Slakeski
  • Patent number: 11564873
    Abstract: The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: January 31, 2023
    Assignee: The University of Melbourne
    Inventor: Eric Charles Reynolds
  • Publication number: 20220401473
    Abstract: The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.
    Type: Application
    Filed: June 3, 2022
    Publication date: December 22, 2022
    Applicant: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Publication number: 20220401037
    Abstract: In an example, a method includes collecting biodata of a subject. The method includes generating or updating a personalized ML model of the subject from the biodata of the subject. The method includes detecting anomalies in the biodata based on the personalized ML model. The method includes filtering the detected anomalies to determine whether the detected anomalies indicate that the subject has a clinical condition or is at risk of having the clinical condition.
    Type: Application
    Filed: June 16, 2021
    Publication date: December 22, 2022
    Inventors: Mehdi Sadeghzadeh, David Jonq Wang, Nivedita Khobragade, Zongde Qiu, I-Ting Chen, Christopher Charles Reynolds, Alexander Katsis, James R. Mault
  • Patent number: 11504305
    Abstract: The present invention relates to compositions and methods for mineralizing a dental surface or subsurface including providing a composition including stabilized ACP and a source of fluoride ions.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: November 22, 2022
    Assignee: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Publication number: 20220183810
    Abstract: The present invention relates to compositions and uses for reducing the visibility of hypomineralised dental surfaces or subsurfaces, in particular in dental enamel. In one aspect, the invention involves a method of reducing visibility of a hypomineralised dental surface or subsurface, the method comprising (i) contacting the hypomineralised dental surface or subsurface with a liquid composition comprising at least 40% w/v of phosphopeptide (PP)-stabilized amorphous calcium phosphate (ACP) and/or amorphous calcium fluoride phosphate (ACFP) at a pH of less than or equal to pH 6; and (ii) subsequently to (i), raising the pH of the liquid composition applied to the hypomineralised dental surface or subsurface to equal to, or greater than, about 9, thereby forming a gel in and/or on the hypomineralised dental surface or subsurface, thereby reducing visibility of a hypomineralised dental surface or subsurface.
    Type: Application
    Filed: March 13, 2020
    Publication date: June 16, 2022
    Applicant: The University of Melbourne
    Inventor: Eric Charles Reynolds