Abstract: The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.

Abstract: The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease.

Abstract: This invention relates to the PrtR-PrtK cell surface protein of Porphyromonas gingivalis and in particular a multimeric cell association protein complex comprising the PrtR and PrtK proteins. Accordingly the invention provides a substantially purified antigenic complex for use in raising an antibody response directed against Porphyromonas gingivalis. The complex comprises at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain, the complex having a molecular weight of greater than about 200 kDa. The invention also relates to pharmaceutical compositions and associated agents based on said complex for the detection, prevention and treatment of Periodontal disease associated with P. gingivalis.

Abstract: The present invention relates to compounds, peptides, peptidomimetics and pharmaceutical compositions that inhibit protease activity, and the use of these compounds, peptides, peptidomimetics and pharmaceutical compositions comprising them to treat or prevent a condition. In particular the condition may be periodontal disease. The compounds, peptides and peptidomimetics may be obtained from various caseins, for example ?-casein, ?-casein and ?-casein. The protease activity which the compounds, peptides, peptidomimetics and pharmaceutical compositions of the invention inhibit includes that of the gingipains.

Abstract: The present invention provides a purified multimeric complex from P. gingivalis. The complex comprises at least one domain from each of RgpA, Kgp and HagA, and has a molecular weight greater than about 300 kDa.

Abstract: The invention provides a composition for use in raising an immune response to P. gingivalis in a subject, the composition comprising an amount effective to raise an immune response of at least one polypeptide having an amino acid sequence substantially identical to at least 50 amino acids, or an antigenic or immunogenic portion, of one of the polypeptides corresponding to accession numbers selected from the group consisting of AAQ65462, AAQ65742, AAQ66991, AAQ65561, AAQ66831, AAQ66797, AAQ66469, AAQ66587, AAQ66654, AAQ66977, AAQ65797, AAQ65867, AAQ65868, AAQ65416, AAQ65449, AAQ66051, AAQ66377, AAQ66444, AAQ66538, AAQ67117 and AAQ67118. The invention also provides a method of preventing or treating a subject for P.

Abstract: The present invention provides a phosphopeptide or phosphoprotein (PP) stabilised amorphous calcium phosphate or amorphous calcium fluoride phosphate complex having a calcium ion greater than about 30 moles of calcium per mole of PP

Abstract: The invention provides a method of preventing, inhibiting or reducing a P. gingivalis biofilm in a subject comprising administering to the subject a pharmaceutical composition comprising an inhibiting agent of a polypeptide that reduces or inhibits biofilm formation and/or biofilm development. Also provided are compositions useful in the prevention, inhibition or treatment of periodontal disease or P. gingivalis infection.

Abstract: Techniques for defining and customizing payment rules and automatically paying charges in accordance with the rules is described. A charge is settled and the charge is posted to an account, for example a credit card account, in the form of a settlement record. An automated payments engine compares the settlement record against payment conditions of one or more payment rules. If a payment condition is satisfied, the automated payments engine initiates a payment according to a payment method associated with the satisfied payment condition.

Abstract: The invention is directed to vaccine compositions and methods based on P. gingivalis proteins identified to be regulated by haem availability that can be used in the prevention and treatment of periodontal disease. In particular, two specific internalin-like P. gingivalis proteins, namely PG0350 and PG1374 involved in the internalization of P. gingivalis by host cells, the hypothetical protein, PG1019 purported to be a cell surface lipoprotein and the alkyl hydroperoxide reductase protein, PG0618 have been identified as useful targets for the prevention and treatment of periodontal disease.

Abstract: The present invention relates to novel antimicrobial composition comprising a peptide which can be obtained from the milk protein casein or chemically synthesised or produced by recombinant DNA technology and a divalent cation.

Abstract: The present invention provides a purified multimeric complex form P. gingivalis. The complex comprises at least one domain from each of RgpA, Kgp and HagA, and has a molecular weight greater than about 300 kDa.

Abstract: The present invention relates to compositions and methods for mineralizing a dental surface or subsurface including providing a composition including stabilized ACP and a source of fluoride ions.

Abstract: A pump has a housing defining a first pumping chamber and a second pumping chamber. The pump also has a first plunger and a second plunger. The pump additionally has at least one driver operatively engaged with at least one of the first and second plungers to move the at least one of the first and second plungers between first and second end positions. The pump further has a common spill passageway fluidly connectable to the first and second pumping chambers and a selector valve disposed between the common spill passageway and the first and second pumping chambers. The selector valve has a body and a ball valve member operably disposed within the body. The ball valve member is movable between a first and a second ball valve member position to selectively fluidly connect the first and second pumping chambers to the common spill passageway.

Abstract: A wireless foot control system includes a receiver and at least one transmitter. The transmitter includes a medium generator for emitting a communication medium, a power supply and at least one foot pedal. The power supply includes a power source, a capacitor bank having a discharge current capacity sufficient to power the medium generator, and a current limiter. The current limiter connects the power source to the capacitor bank, charging the capacitor bank from the power source over a period of time. The foot pedal selectively energizes the medium generator from the capacitor bank. The receiver includes a medium collector for collecting the emitted medium and an electronic circuit. The electronic circuit includes a converter for converting the collected medium to an input control signal and a microprocessor in communication with the converter, the microprocessor having an operating system for generating an output control signal commensurate with the input control signal.

Abstract: The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.

Abstract: A method is provided for mineralizing a dental surface or subsurface including contacting the dental surface with a protein disrupting agent and stabilized amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP).

Abstract: The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease.

Abstract: The present invention is directed to novel 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ?-secretase, also known as ?-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

Abstract: An extendable flag pole assembly, including an angulated cylindrical flag pole holder adapted for the support of a flag pole, whereby the angulated cylindrical flag pole holder is attached to the uppermost portion of a moveable channel, and a galvanized handle is attached to the bottom portion. The moveable channel is attached to a stationary channel by two pivoting connector arms, which move to raise the moveable channel upwards towards a parallel position with the stationary channel. A lock plate is attached to the bottom portion of the stationary channel which corresponds to the bottom of the moveable channel to secure the two channels together in a parallel fashion.