Abstract: The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.

Abstract: Presented herein are distributed implantable hearing systems that have at least a main implant module that is physically separated from a distally positioned inner radio-frequency (RF) coil.

Abstract: A green or living wall is formed on the external architectural surface. The wall includes a waterproof layer to protect the surface from water and other materials from the living wall, and several plant support components extending horizontally in parallel to each other across the wall. The components include a tubular wall filled with a growth media formed of hydromix and/or potting substrate, one or more layers of a water retaining material and an out support layer. Plants are planted on the plant support components with their plants being imbedded into the growth media. The architectural surface may be oriented vertically, horizontally, or at an angle, and filler material may be used to shape the plant support components into various three-dimensional shapes.

Abstract: Disclosed are methods and systems of adapting an optical image stabilizer (OIS) for a camera, the methods comprising acquiring an image of the scene; obtaining image context associated with the image of the scene; selecting a mode of operating the OIS based on the obtained image context; and, applying the OIS using the selected mode of operation.

Abstract: A hinge mechanism for attaching ear accessories to a helmet allows an accessory to be attached at a point outside the helmet shell utilizing, for example, a slidable mounting rail, and to reach under the edge of the helmet shell so that the accessory is supported in contact with the wearer's head. The hinge mechanism is well suited for use in connection with military helmets that have a “bulge” or protrusion over the ear.

Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.

Abstract: Methods for producing an isotope-labeled mammalian, including a human, biomolecule, such as polypeptides and proteins, in a cell-free protein synthesis system. A biomolecule standard is produced having at least one isotope different in abundance than that of the naturally occurring isotopes in the biomolecule. Methods for quantifying biomolecules standards expressed using mammalian cell-free extracts are disclosed. Methods for producing such standards, kits, systems and reagents, relating to the use of isotope-labeled biomolecule as quantification standards in mass spectrometric and nuclear magnetic resonance analysis.

Abstract: The present invention concerns a method for producing an intermediate product for obtaining a photovoltaic module comprising a plurality of solar cells, said method comprising the following steps: (a) localised deposition on a substrate (4) of a layer (7) of an Se or S material, so as to cover at least one portion (400) of the substrate, (b) deposition on this localised layer (7), of a layer (41) of conductive material, said layer coating the localised layer.

Abstract: A method for producing an intermediate product for obtaining a photovoltaic module comprising a plurality of solar cells, said method comprising the following steps: (a) localised deposition on a substrate (4) of a layer of metal (8) so as to cover at least one portion (401) of the substrate, (b) deposition on this localised layer (8) of a layer (41) of conductive material, said layer coating the localised layer (8).

Abstract: Methods for producing an isotope-labeled mammalian, including a human, biomolecule, such as polypeptides and proteins, in a cell-free protein synthesis system. A biomolecule standard is produced having at least one isotope different in abundance than that of the naturally occurring isotopes in the biomolecule. Methods for quantifying biomolecules standards expressed using mammalian cell-free extracts are disclosed. Methods for producing such standards, kits, systems and reagents, relating to the use of isotope-labeled biomolecule as quantification standards in mass spectrometric and nuclear magnetic resonance analysis.

Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.

Abstract: Embodiments are generally directed to a feedthrough for an implantable medical device. The feedthrough comprises an insulator having one or more conductors extending therethrough that is hermetically connected (joined) to a housing of the implantable medical device. More specifically, the housing includes an aperture and the insulator is configured be positioned in the aperture. Braze material is configured to be positioned in one or more indentations in at least one of the housing or the insulator such that the braze material is disposed in the indentations between the insulator and the housing.

Abstract: A method for absolute protein or peptide quantitation by mass spectroscopy. A sample containing a protein or peptide of interest is prepared for mass spectroscopy analysis. The sample is subjected to mass spectroscopy analysis at low resolution whereby a single additive mass spectroscopy peak is obtained, then is subjected to high resolution mass spectroscopy analysis whereby a plurality of mass spectroscopy peaks are obtained. The intensity of each of the plurality of mass spectroscopy peaks is quantitated either by comparison to an internal standard set, or by using a standard curve generated for each isotopologue set. Quantitation using a standard curve enhances quantitation across a dynamic range of analyte.

Abstract: The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.

Abstract: A headgear adjustment mechanism is provided that includes a worm having a central axis of rotation, a first headband element, a second headband element, a spur gear, and a housing. The first headband element includes (i) a worm rack disposed in operative engagement with the worm, and (ii) a first pinion rack. The second headband element includes a second pinion rack. The spur gear is disposed in simultaneous operative engagement with the first pinion rack and the second pinion rack, and the housing at least partially encloses the first and second headband elements. During operation of the adjustment mechanism, rotation of the worm about the axis of rotation causes the first headband element and the second headband element to translate in opposite directions with respect to the worm, thereby adjusting a fit of the headgear.

Abstract: An implantable medical device having a hermetically-sealed biocompatible housing configured to be implanted in a recipient. The implantable medical device includes at least one trans-housing transformer configured to transfer electrical signals through the housing.

Abstract: Presented herein are coil retention systems for use in implantable medical devices. In certain embodiments, a coil retention system comprises an implantable non-magnetized member having a central aperture and an external magnet also having a central aperture. The external magnet is configured to magnetically couple to the implantable non-magnetized member. In certain embodiments, the external magnet and the implantable non-magnetized member have corresponding annular shapes so as to self-align with one another.

Abstract: Disclosed are methods and systems of adapting an optical image stabilizer (OIS) for a camera, the methods comprising acquiring an image of the scene; obtaining image context associated with the image of the scene; selecting a mode of operating the OIS based on the obtained image context; and, applying the OIS using the selected mode of operation.

Abstract: Housing constructions as disclosed herein can be an implantable component of a medical device and are designed to provide an enhanced degree of protection to electrical and/or mechanical components disposed therein to impact forces onto the housing from an external object to thereby increase the effective service life of devices making use of such housing constructions.

Abstract: An improved edge band for a protective helmet includes a flexible woven-fiber elongate band applied to the edge of a helmet shell. The elongate band is positioned such that side edges of the elongate band extend in intimately conforming contact along a surface contour of the helmet shell. The edge band includes a matrix material in contact with fibers of the elongate band.