Abstract: An improved edge band for a protective helmet includes a flexible woven-fiber elongate band applied to the edge of a helmet shell. The elongate band is positioned such that side edges of the elongate band extend in intimately conforming contact along a surface contour of the helmet shell. The edge band includes a matrix material in contact with fibers of the elongate band.

Abstract: A headgear adjustment mechanism is provided that includes a worm having a central axis of rotation, a first headband element, a second headband element, a spur gear, and a housing. The first headband element includes (i) a worm rack disposed in operative engagement with the worm, and (ii) a first pinion rack. The second headband element includes a second pinion rack. The spur gear is disposed in simultaneous operative engagement with the first pinion rack and the second pinion rack, and the housing at least partially encloses the first and second headband elements. During operation of the adjustment mechanism, rotation of the worm about the axis of rotation causes the first headband element and the second headband element to translate in opposite directions with respect to the worm, thereby adjusting a fit of the headgear.

Abstract: A medical implant, such as a cochlear implant, comprising a fixating point which is located remotely from the medical implant. This arrangement can reduce the risk of post operative infection in a patient in which the medical implant is implanted.

Abstract: Methods and sets of non-biological reagents (elution reagents, tag isomers, tag reactive groups, crosslinkers) for single or multiplexed capture and gentle elution of biomolecules. Examples are provided using amine- and cysteine-reactive reagents for enrichment of proteins, peptides, and rare peptide modifications.

Abstract: The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.

Abstract: Disclosed herein are medical prostheses including a cochlear implant that includes circuitry enclosed within a housing and at least one electrode lead extending from the housing. The electrode lead comprises a conducting pathway and an electrode terminal at one end of the electrode lead. The conducting pathway connects the circuitry with the electrode terminal, and insulation (or an insulating sleeve) encloses at least a portion of the conducting pathway. In some embodiments, the electrode terminal has a lower thermal conductivity relative to the implant housing. In further embodiments, the insulation has thermal conductivity and thermal conduction properties that cause at least some thermal energy in the conducting pathway to flow into the insulation rather than to the electrode terminal. In still further embodiments, at least one of the electrode terminal or the electrode lead includes at least one thermal mass enhancing structure.

Abstract: Disclosed herein are medical prostheses including a cochlear implant that includes circuitry enclosed within a housing and at least one electrode lead extending from the housing. The electrode lead comprises a conducting pathway and an electrode terminal at one end of the electrode lead. The conducting pathway connects the circuitry with the electrode terminal, and insulation (or an insulating sleeve) encloses at least a portion of the conducting pathway. In some embodiments, the electrode terminal has a lower thermal conductivity relative to the implant housing. In further embodiments, the insulation has thermal conductivity and thermal conduction properties that cause at least some thermal energy in the conducting pathway to flow into the insulation rather than to the electrode terminal. In still further embodiments, at least one of the electrode terminal or the electrode lead includes at least one thermal mass enhancing structure.

Abstract: Transparency imaging systems and methods. One embodiment of the transparency imaging system comprises an imaging surface and a cover mounted adjacent the imaging surface. A media adapter is provided as part of the cover, and a chamber is formed in the media adapter. At least one template is receivable within the chamber formed in the media adapter, the at least one template loading the transparency media in the media adapter adjacent the imaging surface for an imaging operation.

Abstract: The implantable medical device including a hermetic enclosure including at least one feedthrough having at least one electrically conductive path through the feedthrough. The at least one feedthrough includes an insulator having an entry face and an exit face, and at least one non-linear conductor is configured to extend, within the insulator, from the entry face to the exit face to provide the conductive path, wherein the entry and exit faces are not substantially parallel opposite faces of the insulator.

Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.

Abstract: A medical implant, such as a cochlear implant, comprising a fixating point which is located remotely from the medical implant. This arrangement can reduce the risk of post operative infection in a patient in which the medical implant is implanted.

Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.

Abstract: Methods for producing an isotope-labeled mammalian, including a human, biomolecule, such as polypeptides and proteins, in a cell-free protein synthesis system. A biomolecule standard is produced having at least one isotope different in abundance than that of the naturally occurring isotopes in the biomolecule. Methods for quantifying biomolecules standards expressed using mammalian cell-free extracts are disclosed. Methods for producing such standards, kits, systems and reagents, relating to the use of isotope-labeled biomolecule as quantification standards in mass spectrometric and nuclear magnetic resonance analysis.

Abstract: The present invention refers to a multipurpose plastic bottle made in one reusable piece which is provided with the means for conversion to objects which may be kept by the user. It comprises an upper belt and a lower belt formed by pairs of circular rings connected round the whole profile of the bottle with the connection of both pairs of rings defined by a cutting guide for separating the bottle in an upper section, a mid section and a lower section. The multipurpose plastic bottle which is the object of the invention belongs to the technical sector of plastics, specifically to the plastic industry relating to manufacture of bottles designed to hold liquids for mass distribution and consumption. The products to be bottled are soft drinks, sodas, drinking water, cooking oils and domestic cleaning products.

Abstract: The invention pertains to methods for measuring different forms of human adiponectin that are present in human plasma/serum, and more specifically methods are based on an ELISA assay that utilizes different monoclonal antibodies directed against adiponectin, in combination with different polyclonal antibodies directed against different domains of human adiponectin. The invention also provides unique isoforms of adiponectin and antibodies thereto, including polyclonal and monoclonal antibodies.

Abstract: Embodiments of the present invention relate to an implantable device housing assembly, for use in, for example, implantable prosthetic devices. In one aspect, the present invention provides a housing for an implantable device comprising a body portion and a sealing flange. The body portion includes a cavity in which electronic components are disposed on an open side thereof, and at least one feed-through which provides electrical connections between the electronic components and the exterior of the device. The feed-through includes interior and exterior connection points, which are accessible during assembly of the device from a first side of the device. The sealing flange operatively seals the cavity so as to form a sealed housing. A method of forming a sealed housing for an implantable device is also provided.

Abstract: The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.

Abstract: A system and method reduces AC losses in a magnetic coil with a magnetic core with one or more gaps. A foil winding is formed with one or more cavities and is positioned about the magnetic core such that the cavities are adjacent to the gaps.

Abstract: The present invention refers to a multipurpose plastic bottle made in one reusable piece which is provided with the means for conversion to objects which may be kept by the user. It comprises an upper belt and a lower belt formed by pairs of circular rings connected round the whole profile of the bottle with the connection of both pairs of rings defined by a cutting guide for separating the bottle in an upper section, a mid section and a lower section. The multipurpose plastic bottle which is the object of the invention belongs to the technical sector of plastics, specifically to the plastic industry relating to manufacture of bottles designed to hold liquids for mass distribution and consumption. The products to be bottled are soft drinks, sodas, drinking water, cooking oils and domestic cleaning products.

Abstract: A method of forming a braze join between two components is disclosed, in which braze material is introduced into a gap between the two components by capillary action. This assists in reducing flooding. Also disclosed is a component for use with the method, and an assembly produced by the method. In one form, the component comprises a recess or reservoir for storing braze material, in fluid communication with an aperture to allow the braze material to be drawn into the gap by capillary forces. The method may be used in a number of applications including medical devices and more specifically, a cochlear implant.