Abstract: This document describes an automated external defibrillator comprising a control configured to switch between a pediatric operating mode and an adult operating mode, wherein each operating mode comprises a mode-specific energy configuration and a mode-specific user configuration; an indicator configured to provide an indication of the operating mode in use during a resuscitation process; one or more processors configured to switch to the mode-specific energy configuration and the mode-specific user configuration upon a change of operating mode between the pediatric operating mode and the adult operating mode such that the automated external defibrillator delivers a defibrillating shock to a patient based on the mode-specific energy configuration; and an interface of the automated external defibrillator provides resuscitation instructions to a user based on the mode-specific user configuration.

Abstract: The present invention provides compounds, compositions thereof, and processes for preparing same.

Abstract: A patient interface, such as a nasal cannula, including a body to be positioned upon a user (preferably such as a user's face), the body including at least one (and preferably a pair of) nasal prong(s), the or each nasal prong including a lumen capable of being fluidly connected thereto for fluid communication with a supply of breathable gas, the or each nasal prong to be in a configuration either inserted into, or to direct a flow of gas toward, a nare or the nares of the user's nose, wherein the body includes at least one element responsive to force(s) or movement(s), or both, experienced by at least a first region of the patient interface.

Abstract: A data processing system implements receiving a first input in a spreadsheet in a spreadsheet application, detecting an indication that the first input includes first executable program code, analyzing the first executable program code to identify first references to one or more first elements of the spreadsheet in the first executable program code, requesting spreadsheet data associated with the one or more first elements of the spreadsheet from the spreadsheet application, receiving the spreadsheet data from the spreadsheet application; executing the first executable program code using the spreadsheet data referenced in the first executable program code to obtain a first program code result and causing the spreadsheet application to display the first program code result in the spreadsheet application.

Abstract: An electromagnetic splitting coupler is provided for receiving a transverse electromagnetic (TEM) signal input and emitting a transverse electric mode one-zero (TE10) signal output. The coupler includes a receiver port; a plurality of emitter ports; a hollow manifold; and a terminus. The receiver port provides the TEM signal input. The emitter ports impart the TE10 signal output. The manifold includes a chamber that connects the receiver port to the emitter ports. The terminus seals the manifold. The coupler can also include an interface plate to connect the emitter ports thereto, such as to an antenna.

Abstract: A method and apparatus for containing one or more shaped charges in a single plane, arrayed about the center axis of a gun body, and detonated from a single initiator in a shaped charge cluster assembly, having one or more detonator circuits located within a recess within the shaped charge cluster assembly electrically coupled to the single initiator located at the center of the arrayed shaped charges.

Abstract: A patient interface, such as a nasal cannula is described. The patient interface has a body portion to be located, in-use upon a face of a user. The body portion has at least one side arm that extends laterally from a central bridge portion to be located about a user's septum region, where each side arm is connected to a resilient, or relatively more rigid, bridge portion element. The interface has at least one, and preferably a pair of, nasal prong(s). The body portion has at least one fluid passageway connected to the nasal prong(s) for supply of a gas to the nare(s) of the user's nose. A cross section of the passageway varies along the length of the body portion to regions of varying flexibility along the body portion. The bridge portion element defines a substantially predetermined spatial relationship for outlet(s) of a gas delivery system supplying gas via each side arm to the outlet(s) from which, for example, the nasal prong(s) may be provided in fluid connection.

Abstract: The present invention relates to the use of a specific binding molecules which binds human ANXA1 in combination with a second active agent for use in the treatment of cancer. Second active agents include thy midylate synthetase inhibitors, nucleobase analogues, checkpoint inhibitors, proteasome inhibitors, taxanes, platinum-based chemotherapy agents and nucleoside analogues. Preferred cancers for treatment are pancreatic cancer, colorectal cancer, breast cancer, lung cancer, myeloma and mantle cell lymphoma. Related kits, products and uses are also provided.

Abstract: The present invention provides compounds, compositions thereof, and processes for preparing same.

Abstract: Genetically engineered hematopoietic cells, which express one or more factors that redirect glucose metabolites, and optionally a chimeric receptor polypeptide (e.g., an antibody-coupled T cell receptor (ACTR) polypeptide, a chimeric antigen receptor (CAR) polypeptide, or a TCR polypeptide) capable of binding to a target antigen of interest. Also disclosed herein are uses of the engineered hematopoietic cells for inhibiting cells expressing a target antigen in a subject in need thereof.

Abstract: Disclosed herein are genetically engineered hematopoietic cells, which express one or more Krebs cycle modulating polypeptides, and optionally a chimeric receptor polypeptide (e.g., an antibody-coupled T cell receptor (ACTR) polypeptide or a chimeric antigen receptor (CAR) polypeptide) capable of binding to a target antigen of interest. Also disclosed herein are uses of the engineered hematopoietic cells for inhibiting cells expressing a target antigen in a subject in need thereof.

Abstract: Disclosed herein are genetically engineered hematopoietic cells, which express one or more Krebs cycle modulating polypeptides, and optionally a chimeric receptor polypeptide (e.g., an antibody-coupled T cell receptor (ACTR) polypeptide or a chimeric antigen receptor (CAR) polypeptide) capable of binding to a target antigen of interest. Also disclosed herein are uses of the engineered hematopoietic cells for inhibiting cells expressing a target antigen in a subject in need thereof.

Abstract: A pillow uses a fan assembly in the pillow to cool the sleeping surface of the pillow. The fan assembly uses two fans to move ambient air through a middle layer of reticulated foam and then through air passages extending through at least one layer of foam. A bottom piece of foam is either semi-permeable or impermeable to airflow so that most, if not all, of the air moved by the fans exits the top of the pillow to cool the pillow. A chargeable power source powers the fans via a circuit board which may have an LED light to indicate the status of the power source.

Abstract: A patient interface, such as a nasal cannula is described. The patient interface has a body portion to be located, in-use upon a face of a user. The body portion has at least one side arm that extends laterally from a central bridge portion to be located about a user's septum region, where each side arm is connected to a resilient, or relatively more rigid, bridge portion element. The interface has at least one, and preferably a pair of, nasal prong(s). The body portion has at least one fluid passageway connected to the nasal prong(s) for supply of a gas to the nare(s) of the user's nose. A cross section of the passageway varies along the length of the body portion to regions of varying flexibility along the body portion. The bridge portion element defines a substantially predetermined spatial relationship for outlet(s) of a gas delivery system supplying gas via each side arm to the outlet(s) from which, for example, the nasal prong(s) may be provided in fluid connection.