Abstract: Methods, systems, and computer-readable media for controlling a toolface of a downhole tool are described. The toolface of the downhole tool, and a toolface setpoint, are determined. Based on the toolface and the toolface setpoint, a toolface error is determined. Based on the toolface error, one or more drilling parameter setpoints are selected from among multiple drilling parameter setpoints. The selected one or more drilling parameter setpoints are adjusted. The adjusted one or more drilling parameter setpoints are inputted to one or more drilling controllers for controlling the toolface of the downhole tool.

Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

Abstract: A cable storage wheel for communication cables is provided. The cable storage wheel has a channel that receives the communication cable and a plurality of cable tie features. The cable tie features are positioned for receipt of cable ties to secure the communication cable in the channel in a manner that minimizes or eliminates contact between the wire ties and the communication cable. In this manner, the cable storage wheel is configured and designed to encourage the user to wrap the wire ties around the storage wheel and, not the communication cable. The cable tie features are, in some embodiments, slots, notches, openings, channel supports, and any combinations thereof.

Abstract: The foam and fiber composite can provide an absorbent article with improved dryness and an improved liquid distribution capability. The foam and fiber composite can be formed from at least two materials. The first material is an open cell foam material and the second material is a fibrous material. A plurality of the fibers forming the fibrous material can be fluid inserted into the open cell foam material thereby forming the foam and fiber composite. In various embodiments, the foam and fiber composite can be incorporated into an absorbent article as a component of an absorbent system located between a topsheet layer and a backsheet layer of the absorbent article.

Abstract: The foam and fiber composite can provide an absorbent article with improved dryness and an improved liquid distribution capability. The foam and fiber composite can be formed from at least two materials. The first material is an open cell foam material and the second material is a fibrous material. A plurality of the fibers forming the fibrous material can be fluid inserted into the open cell foam material thereby forming the foam and fiber composite. In various embodiments, the foam and fiber composite can be incorporated into an absorbent article as a component of an absorbent system located between a topsheet layer and a backsheet layer of the absorbent article.

Abstract: An interface device, coloring agent and method for imparting color to food material during the decorating of foods. This interface device, coloring agent and method for imparting color to food material during the decorating of foods can be used to impart color from solid, liquid or semi-liquid coloring compounds to a wide variety of food material such as frosting and icing.

Abstract: A system includes at least one hardware processor and a memory storing instructions that, when executed by the at least one hardware processor, cause the at least one hardware processor to perform operations including identifying a component of tracked conduct, the component of tracked conduct including a first conduct trigger condition and a reward, the first conduct trigger condition is associated with conduct of a user related to retirement, receiving conduct data associated with the first conduct trigger condition from a first data source, determining, using the conduct data, that the first conduct trigger condition is satisfied, and causing the reward to be provided to the user.

Abstract: A system includes at least one hardware processor and a memory storing instructions which, when executed, cause the hardware processor to perform operations including identifying a notification trigger configured by a user of a target computing device, the notification trigger including at least one trigger condition and notification content, the trigger condition references a value from a trigger data source and includes a condition based on the value, the notification content includes content provided by the user, receiving the value from the trigger data source, determining, based on the value, that the at least one trigger condition is satisfied, and presenting the notification content to the user on a target computing device associated with the user, the notification content is presented in a target content venue configured to present third-party advertisements to the user.

Abstract: A geospatial data collection system is for an aerial vehicle and includes a data collection light detection and ranging (LiDAR) device and a protection LiDAR device. The data collection LiDAR device is configured to collect geospatial data as the aerial vehicle moves along a collection path. The protection LiDAR device is configured to sense a geospatial area ahead of the data collection LiDAR device. The data collection LiDAR device is switchable from an operating mode to a protected mode based upon the protection LiDAR device.

Abstract: Methods, systems, and techniques for controlling the rate of penetration of a drill bit use drilling parameter measurements read from drilling parameter sensors to evaluate control loops, with the output of one of the control loops at any given time being used by an automatic driller to control the rate of penetration. For each of the drilling parameters, the automatic driller reads a drilling parameter measurement, determines an error measurement that represents a difference between a drilling parameter setpoint and the drilling parameter measurement, and from the error measurement determines an output signal proportional to the rate of penetration of the drill bit. The output signal of one of the control loops is subsequently selected and used to control the rate of penetration.

Abstract: The present invention relates to an isolated specific binding molecule which binds human Anx-A1 and comprises the complementarity-determining regions (CDRs) VLCDR1, VLCDR2, VLCDR3, VHCDR1, VHCDR2 and VHCDR3, wherein each of said CDRs has an amino add sequence as follows: VLCDR1 has the sequence set forth in SEQ ID NO: 1, 36 or 37; VLCDR2 has the sequence set forth in SEQ ID NO: 2; VLCDR3 has the sequence set forth in SEQ ID NO: 3; VHCDR1 has the sequence set forth in SEQ ID NO: 4; VHCDR2 has the sequence set forth in SEQ ID NO: 5; and VHCDR3 has the sequence set forth in SEQ ID NO: 6; or, for each sequence, an amino acid sequence with at least 85% sequence identity thereto. The specific binding molecule disclosed is therapeutically useful and in particular may be used in therapy for T-cell mediated diseases, including autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, obsessive compulsive disorder (OCD), and OCD-related diseases, such as anxiety disorders.