Patents by Inventor Charles Z. Ding

Charles Z. Ding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250230156
    Abstract: Disclosed is a crystal form of an allyl-containing methylpyridopyrimidine compound, and specifically discloses a crystal form of a compound as shown in formula (I) and of a salt of the compound.
    Type: Application
    Filed: January 16, 2023
    Publication date: July 17, 2025
    Inventors: Lifang Wu, Fei Sun, Charles Z. Ding
  • Patent number: 12338263
    Abstract: Disclosed are a new class of antibacterial aminoglycoside derivatives, pharmaceutical compositions containing such compounds, and application thereof in the preparation of drugs for treating diseases related to bacterial infections. Specifically disclosed are a compound represented by formula (II), pharmaceutically acceptable salts thereof, and isomers thereof.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: June 24, 2025
    Assignee: ZHUOHE PHARMACEUTICAL GROUP CO., LTD
    Inventors: Dongdong Tang, Zhigang Huang, Cheng Li, Charles Z. Ding, Shuhui Chen
  • Publication number: 20250171474
    Abstract: A crystal form of an isochroman compound and a preparation method therefor. A compound as shown in formula (I) and an application of the compound in preparation of drugs for treating related diseases are specifically involved.
    Type: Application
    Filed: March 8, 2023
    Publication date: May 29, 2025
    Inventors: Zhe CAI, Fei SUN, Charles Z. DING
  • Patent number: 12310948
    Abstract: An application of a compound represented by formula (I) and pharmaceutically acceptable salts thereof in preparation of a drug for treating pneumonia.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: May 27, 2025
    Assignee: SHENZHEN OPTIMUM BIOLOGICAL TECHNOLOGY CO., LTD
    Inventors: Xiawei Wei, Charles Z. Ding, Jian Li, Shuhui Chen, Yuquan Wei
  • Publication number: 20250154166
    Abstract: Disclosed in the present invention is a new 11-oxo-7,11-dihydro-6h-benzo-[f]pyrido[1,2-d][1,4]azepine oxepin-10-carboxylic acid derivative serving as a hepatitis B virus surface antigen inhibitor. Specifically disclosed are a compound represented by formula (V) or a pharmaceutically acceptable salt thereof, and applications of the compound represented by formula (V) or the pharmaceutically acceptable salt thereof and a pharmaceutical composition thereof in the treatment of viral hepatitis B.
    Type: Application
    Filed: January 14, 2025
    Publication date: May 15, 2025
    Applicant: Fujian Akeylink Biotechnology Co., Ltd.
    Inventors: Charles Z. DING, Fei SUN, Yanbin HU, Shuhui CHEN
  • Publication number: 20250109156
    Abstract: The present invention provides indole-containing macrocyclic compounds and the uses thereof, and particularly relates to compounds represented by formula (II) or pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: January 16, 2023
    Publication date: April 3, 2025
    Inventors: Yingchun LIU, Lihong HU, Charles Z. DING
  • Patent number: 12221432
    Abstract: Provided is an indole compound. In particular, disclosed are a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof and a use of the same as an estrogen receptor antagonist in preparing a drug for treating estrogen receptor-positive breast cancer.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: February 11, 2025
    Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Shuwen Duan, Jianyu Lu, Lihong Hu, Charles Z. Ding, Guoping Hu, Jian Li, Shuhui Chen
  • Publication number: 20250042912
    Abstract: Disclosed are a non-fluorinated quinolone compound and use thereof, specifically relating to a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 30, 2022
    Publication date: February 6, 2025
    Applicants: GUANGZHOU BAIYUNSHAN PHARMACEUTICAL HOLDINGS CO., LTD. BAIYUNSHAN PHARMACEUTICAL GENERAL FACTORY, MEDSHINE DISCOVERY INC.
    Inventors: Jiansong WANG, Dongdong TANG, Zhibo LUO, Zhigang HUANG, Haiwen HUANG, Charles Z. DING, Shuhui CHEN
  • Publication number: 20240409543
    Abstract: Disclosed are a pyrrolopyrazole spiro compound, and the use thereof in preparing a drug for treating related diseases. The present invention specifically relates to a compound as represented by formula (I?), and a stereoisomer and a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 27, 2022
    Publication date: December 12, 2024
    Inventors: Xiangyu FU, Charles Z. DING, Lihong HU
  • Patent number: 12122780
    Abstract: Disclosed are a pyrimidinyl group-containing tricyclic compound and applications thereof in preparing a cancer-treating medicament. Specifically disclosed are a compound as represented by formula (I), a pharmaceutically acceptable salt of same, or an isomer thereof.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: October 22, 2024
    Assignee: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD.
    Inventors: Xile Liu, Charles Z. Ding, Shuhui Chen, Lihong Hu, Haiwen Wan
  • Patent number: 12103936
    Abstract: The present invention discloses a crystal form of a hepatitis B surface antigen inhibitor and a preparation method therefor, and also comprises the use of the crystal form in preparing the hepatitis B surface antigen inhibitor.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: October 1, 2024
    Assignee: FUJIAN AKEYLINK BIOTECHNOLOGY CO., LTD.
    Inventors: Yanbin Hu, Fei Sun, Shenyi Shi, Yanxiao Su, Charles Z. Ding
  • Patent number: 12098127
    Abstract: Provided are a salt form of an estrogen receptor down-regulator, a crystalline form thereof, and a preparation method therefor
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: September 24, 2024
    Assignees: LUOXIN PHARMACEUTICAL (SHANGHAI) CO., LTD., SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD.
    Inventors: Huijun He, Shenyi Shi, Jianyu Lu, Charles Z. Ding, Lihong Hu, Bin Shi, Wenqian Yang, Jiaqiang Dong, Tie-Lin Wang
  • Patent number: 12071435
    Abstract: The present invention relates to a structurally novel TLR8 (Toll-like receptor 8) agonist and, in particular, to a compound thereof of formula (I), a pharmaceutically acceptable salt and an isomer thereof.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: August 27, 2024
    Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Fei Sun, Zhe Cai, Charles Z. Ding, Shuhui Chen
  • Patent number: 12054482
    Abstract: A TLR8 (Toll-like receptor 8) agonist, a compound of the structure shown in formula (I), an isomer thereof, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: August 6, 2024
    Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Zhe Cai, Fei Sun, Charles Z. Ding, Shuhui Chen
  • Publication number: 20240217953
    Abstract: A bicyclic substituted aromatic carboxylic acid compound, in particular a compound as represented by formula (I) and a pharmaceutically acceptable salt thereof. In formula (I), R2 and R3 and atoms connected thereto together form a 3-6 membered heterocyclic group, or R2 and R4 and atoms connected thereto together form a 3-6 membered heterocyclic group. The compound has obvious inhibitory activity on activation of a human serum alternative pathway and significant binding activity to human complement Factor B protein, and also has relatively good in-vivo pharmacodynamic and pharmacokinetic properties.
    Type: Application
    Filed: April 15, 2022
    Publication date: July 4, 2024
    Applicants: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., MEDSHINE DISCOVERY INC.
    Inventors: Charles Z DING, Xiaobing YAN, Fei SUN, Wen JIANG, Jian LI, Shuhui CHEN
  • Patent number: 12018027
    Abstract: Disclosed are a class of macrocyclic derivatives, a preparation method therefor, a pharmaceutical composition containing the derivatives, and the use thereof as therapeutic agents, particularly as XIa factor inhibitors and in the preparation of a drug for treating and preventing thromboembolisms and other diseases. Particularly disclosed are compounds shown by formula (I), an isomer thereof and a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: June 25, 2024
    Assignee: China Resources Biopharmaceutical Company Limited
    Inventors: Yaxian Cai, Xiaobing Yan, Ting Wang, Chengde Wu, Charles Z. Ding, Shuhui Chen
  • Publication number: 20240190861
    Abstract: Disclosed is an aminopyrimidine compound as a CDK2/4/6 inhibitor, and specifically disclosed are the compound represented by formula (I) and a pharmaceutically acceptable salt thereof, and an application of the compound represented by formula (I) and the pharmaceutically acceptable salt thereof in the preparation of a medicament for treating solid tumor.
    Type: Application
    Filed: October 16, 2020
    Publication date: June 13, 2024
    Inventors: Ming ZHOU, Zhaobing XU, Gang LI, Lihong HU, Charles Z. DING, Wen JIANG, Guoping HU, Jian LI, Shuhui CHEN
  • Publication number: 20240189292
    Abstract: The present invention relates to a series of substituted pyridine-2,4-dione derivatives and preparation methods therefor, and in particular, to a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 25, 2022
    Publication date: June 13, 2024
    Inventors: Xiaobing YAN, Wei LAI, Charles Z. DING, Shuhui CHEN
  • Publication number: 20240132491
    Abstract: An indoline compound. Specifically disclosed is an application of a compound represented by formula (I) and pharmaceutically acceptable salts thereof in the preparation of drugs for treating related diseases.
    Type: Application
    Filed: February 8, 2022
    Publication date: April 25, 2024
    Inventors: Jianyu LU, Charles Z. DING, Huijun HE, Lihong HU, Yuanyuan HUANG, Jian LI, Shuhui CHEN
  • Publication number: 20240043401
    Abstract: A salt form of a tetra-substituted olefin compound, a crystal of the compound and the salt, and a preparation method relating to a crystal of a compound represented by formula (I), a salt thereof, a crystal of the salt thereof, and a preparation method therefor.
    Type: Application
    Filed: December 30, 2021
    Publication date: February 8, 2024
    Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Shuwen DUAN, Jianyu LU, Ting YAO, Lihong HU, Charles Z. DING, Jian LI, Shuhui CHEN, Xiquan ZHANG