Patents by Inventor Charles Z. Ding

Charles Z. Ding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal form, salt type of substituted 2-hydro-pyrazole derivative and preparation method therefor
    Patent number: 10626107
    Abstract: A crystal form and a salt type of a substituted 2-hydro-pyrazole derivative, preparation method therefor, and use of the crystal form and the salt type in preparation of a medicament for treating cancers such as breast cancer, lung cancer and the like.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: April 21, 2020
    Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Charles Z. Ding, Shuhui Chen, Lihong Hu, Zhaobing Xu, Yingchun Liu, Bingjie Ren, Weidong Li, Zongbin Li, Rui Zhao, Xiquan Zhang
  • JAK inhibitor
    Patent number: 10617690
    Abstract: The present invention discloses a series of JAK inhibitors, and particularly discloses a compound of formula (I) or a pharmaceutically acceptable salt thereof and the use thereof in preparation of drugs for treating diseases related to JAK.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: April 14, 2020
    Assignee: WUXI FORTUNE PHARMACEUTICAL CO., LTD
    Inventors: Hao Wu, Weiwei Mao, Lili Fan, Charles Z. Ding, Shuhui Chen, Fei Wang, Guoping Hu, Jian Li
  • HEPATITIS B VIRUS SURFACE ANTIGEN INHIBITOR
    Publication number: 20200039995
    Abstract: 10-oxo-6,1-dihydrobenzo[e]pyrido[1,2-c][1,3]oxazine-9-carboxylic acid derivatives of formula (I) as hepatitis B surface antigen inhibitors or pharmaceutically acceptable salts thereof, and uses of a compound of formula (I) or pharmaceutically acceptable salts thereof and pharmaceutical compositions thereof in preparation of medicaments for treatment of viral hepatitis B.
    Type: Application
    Filed: March 9, 2018
    Publication date: February 6, 2020
    Applicants: FUJIAN COSUNTER PHARMACEUTICAL CO., LTD., MEDSHINE DISCOVERY INC.
    Inventors: Fei SUN, Jinhua DU, Yanbin HU, Lili ZHOU, Charles Z. DING, Shuhhui CHEN
  • Benzotriazole-derived ? and ?-unsaturated amide compound used as TGF-? RI inhibitor
    Patent number: 10548883
    Abstract: A benzotriazole-derived ? and ?-unsaturated amide compound used as TGF-?R1 inhibitor or a pharmaceutically acceptable salt thereof, the structure of the compound being as shown in formula (I).
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: February 4, 2020
    Assignees: Genfleet Therapeutics (Shanghai) Inc., Medshine Discovery Inc.
    Inventors: Fei Sun, Lifang Wu, Charles Z. Ding, Guoping Hu, Jian Li, Shuhui Chen, Jianyu Lu
  • NOVEL BETA-LACTAMASE INHIBITORS
    Publication number: 20200010467
    Abstract: Disclosed in the present invention is a type of novel ?-lactamase inhibitors, and specifically disclosed are a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 2, 2017
    Publication date: January 9, 2020
    Applicant: MEDSHINE DISCOVERY INC.
    Inventors: Boyu HU, Charles Z. DING, Zhigang HUANG, Ruibin LIN, Minliang XIAO, Jinsheng XIE, Shuhui CHEN, Cheng LI
  • Substituted-indole-compounds as estrogen receptor down-regulators
    Patent number: 10519143
    Abstract: Disclosed is a new indole compound, in particular, the compound as shown in formula (I), and a preparation method, pharmaceutical composition and use thereof as an estrogen receptor down-regulator in preparing drugs for treating estrogen receptor-positive breast cancer.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: December 31, 2019
    Assignee: LUOXIN PHARMACEUTICAL (SHANGHAI) CO., LTD.
    Inventors: Jianyu Lu, Charles Z. Ding, Lihong Hu, Huijun He, Shuhui Chen, Jiaqiang Dong, Tie-Lin Wang
  • Benzimidazole-linked indole compound acting as novel divalent IAP antagonist
    Patent number: 10508103
    Abstract: The present invention discloses a benzimidazole-linked indole compound acting as novel divalent IAP antagonist, specifically disclosing the compound shown in formulas (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: December 17, 2019
    Assignee: MEDSHINE DISCOVERY INC.
    Inventors: Fei Sun, Charles Z. Ding, Zhe Cai, Wenyuan Qian, Guoping Hu, Jian Li, Shuhui Chen
  • Salt Type And Crystal Type Of 4h-Pyrazolo [1, 5-Alpha] Benzimidazole Compound And Preparation Method And Intermediate Thereof
    Publication number: 20190375756
    Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1, 5-alpha]benzimidazole compound and the preparation method and intermediate thereof.
    Type: Application
    Filed: August 22, 2019
    Publication date: December 12, 2019
    Inventors: Xuehai WANG, Charles Z. DING, Jie SHEN, Shuhui CHEN, Lie LI, Gang LI, Yong XU, Cailin WANG, Ronghua TU, Jimeng WANG, Yang YUE, Biao DENG, Hailiang CHEN, Hui LIU, Wenjie SUN, Cong WANG, Lu HUANG, Zheng WANG, Weidong LI
  • Pyridone compound as c-met inhibitor
    Patent number: 10501443
    Abstract: Disclosed in the present invention is a type of pyridone compounds as c-met inhibitors, and specifically disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: December 10, 2019
    Assignee: FUJIAN COSUNTER PHARMACEUTICAL CO., LTD.
    Inventors: Xiongbin Xu, Gang Li, Charles Z. Ding, Lihong Hu, Guoping Hu, Jian Li, Shuhui Chen, Zhigang Chi, Kun Wang
  • Fused-ring or tricyclic aryl pyrimidine compound used as kinase inhibitor
    Patent number: 10494373
    Abstract: Disclosed is a fused-ring or tricyclic aryl pyrimidine compound used as a mutation selectivity EGFR inhibitor. Specifically, disclosed is a compound represented by formula (I) and used as an EGFR inhibitor or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: December 3, 2019
    Assignee: Guangdong Zhongsheng Pharmaceutical Co., Ltd
    Inventors: Charles Z. Ding, Shuhui Chen, Baoping Zhao, Xile Liu, Linxia Xiao, Chao Ding, Fei Wang, Jian Li
  • INDOLO SUBSTITUTED PIPERIDINE COMPOUND AS ESTROGEN RECEPTOR DEGRADING AGENT
    Publication number: 20190337938
    Abstract: Disclosed in the present invention is a type of indole substituted piperidine compounds as an estrogen receptor degrading agent. Specifically disclosed are a compound as shown in formula (I), a pharmaceutically acceptable salt, hydrate or prodrug thereof, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof as an estrogen receptor degrading agent in the treatment of estrogen receptor positive breast cancers.
    Type: Application
    Filed: October 30, 2017
    Publication date: November 7, 2019
    Applicants: LUOXIN PHARMACEUTICAL (SHANGHAI) CO., LTD., SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD.
    Inventors: Jianyu LU, Charles Z. DING, Xu ZENG, Huijun HE, Shuhui CHEN, Lihong HU, Jiaqiang DONG, Tie-Lin WANG
  • CDK4/6 INHIBITOR
    Publication number: 20190315745
    Abstract: Disclosed is a series of compounds acting as CDK4/6 inhibitors. Specifically disclosed are compounds as represented by formula (I), pharmaceutically acceptable salts or isomers thereof, pharmaceutical compositions containing same, and the use thereof in the preparation of drugs for treating cancers.
    Type: Application
    Filed: December 15, 2017
    Publication date: October 17, 2019
    Inventors: Zhaobing XU, Lihong HU, Charles Z. DING, Shuhui CHEN
  • Salt type and crystal type of 4H-pyrazolo [1, 5-alpha] benzimidazole compound and preparation method and intermediate thereof
    Patent number: 10428073
    Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1,5-alpha]benzimidazole compound and a preparation method and intermediate thereof.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: October 1, 2019
    Assignees: Hubei Bio-Pharmaceutical Industrial Technological Institute Inc., Humanwell Healthcare (Group) Co., Ltd.
    Inventors: Xuehai Wang, Charles Z. Ding, Jie Shen, Shuhui Chen, Lie Li, Gang Li, Yong Xu, Cailin Wang, Ronghua Tu, Jimeng Wang, Yang Yue, Biao Deng, Hailiang Chen, Hui Liu, Wenjie Sun, Cong Wang, Lu Huang, Zheng Wang, Weidong Li
  • M-DIHYDROXYBENZENE DERIVATIVE CRYSTAL AND SALT, AND MANUFACTURING METHOD THEREOF
    Publication number: 20190284146
    Abstract: Provided are a crystal and salt of an m-dihydroxybenzene derivative represented by formula (I), a manufacturing method thereof, and an application of the crystal in preparing a pharmaceutical product for treating a HSP90-mediated disease.
    Type: Application
    Filed: July 20, 2017
    Publication date: September 19, 2019
    Inventors: Xiaobing YAN, Wei HUANG, Dan LI, Charles Z. DING, Fei LIU, Xiquan ZHANG
  • CRYSTAL AND SALT OF NITROIMIDAZOLE, AND MANUFACTURING METHOD THEREOF
    Publication number: 20190276475
    Abstract: The present invention discloses a crystal form and salt of a nitroimidazole compound, and a manufacturing method thereof. The invention further comprises an application of the crystal form and salt in preparing a pharmaceutical product for preventing and treating an infection caused by Mycobacterium tuberculosis or another microbe.
    Type: Application
    Filed: July 21, 2017
    Publication date: September 12, 2019
    Applicant: Medshine Discovery Inc.
    Inventors: Wei LUO, Charles Z. DING, Zhigang HUANG, Yinghu HU, Zongbin LI, Qingqing LU
  • PYRIDONE COMPOUND AS C-MET INHIBITOR
    Publication number: 20190248763
    Abstract: Disclosed in the present invention is a type of pyridone compounds as c-met inhibitors, and specifically disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 23, 2017
    Publication date: August 15, 2019
    Applicant: FUJIAN COSUNTER PHARMACEUTICAL CO., LTD.
    Inventors: Xiongbin XU, Gang LI, Charles Z. DING, Lihong HU, Guoping HU, Jian LI, Shuhui CHEN, Zhigang CHI, Kun WANG
  • DIHYDROPYRAZOLE AZEPINE COMPOUND SERVING AS AKT INHIBITOR
    Publication number: 20190233434
    Abstract: Provided is a dihydropyrazole azepine compound serving as an Akt inhibitor; specifically disclosed is a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 13, 2017
    Publication date: August 1, 2019
    Inventors: Lun LU, Zhibo ZHANG, Gang LI, Lihong HU, Charles Z. DING, Shuhui CHEN
  • CRYSTAL FORM, SALT TYPE OF SUBSTITUTED 2-HYDRO-PYRAZOLE DERIVATIVE AND PREPARATION METHOD THEREFOR
    Publication number: 20190194168
    Abstract: A crystal form and a salt type of a substituted 2-hydro-pyrazole derivative, preparation method therefor, and use of the crystal form and the salt type in preparation of a medicament for treating cancers such as breast cancer, lung cancer and the like.
    Type: Application
    Filed: September 8, 2017
    Publication date: June 27, 2019
    Inventors: Charles Z. Ding, Shuhui Chen, Lihong Hu, Zhaobing Xu, Yingchun Liu, Bingjie Ren, Weidong Li, Zongbin Li, Rui Zhao, Xiquan Zhang
  • BENZOTRIAZOLE-DERIVED ALPHA AND BETA-UNSATURATED AMIDE COMPOUND USED AS TGF-BETA RI INHIBITOR
    Publication number: 20190151299
    Abstract: A benzotriazole-derived ? and ?-unsaturated amide compound used as TGF-?R1 inhibitor or a pharmaceutically acceptable salt thereof, the structure of the compound being as shown in formula (I).
    Type: Application
    Filed: June 8, 2017
    Publication date: May 23, 2019
    Inventors: Fei SUN, Lifang WU, Charles Z. DING, Guoping HU, Jian LI, Shuhui CHEN, Jianyu LU
  • BENZIMIDAZOLE-LINKED INDOLE COMPOUND ACTING AS NOVEL DIVALENT IAP ANTAGONIST
    Publication number: 20190135794
    Abstract: The present invention discloses a benzimidazole-linked indole compound acting as novel divalent IAP antagonist, specifically disclosing the compound shown in formulas (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 27, 2017
    Publication date: May 9, 2019
    Inventors: Fei SUN, Charles Z. DING, Zhe CAI, Wenyuan QIAN, Guoping HU, Jian LI, Shuhui CHEN