Patents by Inventor Charles Z. Ding

Charles Z. Ding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZOTRIAZOLE-DERIVED ALPHA AND BETA-UNSATURATED AMIDE COMPOUND USED AS TGF-BETA RI INHIBITOR
    Publication number: 20190151299
    Abstract: A benzotriazole-derived ? and ?-unsaturated amide compound used as TGF-?R1 inhibitor or a pharmaceutically acceptable salt thereof, the structure of the compound being as shown in formula (I).
    Type: Application
    Filed: June 8, 2017
    Publication date: May 23, 2019
    Inventors: Fei SUN, Lifang WU, Charles Z. DING, Guoping HU, Jian LI, Shuhui CHEN, Jianyu LU
  • BENZIMIDAZOLE-LINKED INDOLE COMPOUND ACTING AS NOVEL DIVALENT IAP ANTAGONIST
    Publication number: 20190135794
    Abstract: The present invention discloses a benzimidazole-linked indole compound acting as novel divalent IAP antagonist, specifically disclosing the compound shown in formulas (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 27, 2017
    Publication date: May 9, 2019
    Inventors: Fei SUN, Charles Z. DING, Zhe CAI, Wenyuan QIAN, Guoping HU, Jian LI, Shuhui CHEN
  • SUBSTITUTED-INDOLE-COMPOUNDS AS ESTROGEN RECEPTOR DOWN-REGULATORS
    Publication number: 20190106414
    Abstract: Disclosed is a new indole compound, in particular, the compound as shown in formula (I), and a preparation method, pharmaceutical composition and use thereof as an estrogen receptor down-regulator in preparing drugs for treating estrogen receptor-positive breast cancer.
    Type: Application
    Filed: March 24, 2017
    Publication date: April 11, 2019
    Inventors: Jianyu LU, Charles Z. DING, Lihong HU, Huijun HE, Shuhui CHEN, Jiaqiang DONG, Tie-Lin WANG
  • Anti-pulmonary tuberculosis nitroimidazole derivative
    Patent number: 10227362
    Abstract: Disclosed is a substituted nitroimidazole derivative, which is mainly used for treating related diseases caused by mycobacterial infections, such as Mycobacterium tuberculosis, especially being suitable for diseases caused by resistant Mycobacterium tuberculosis.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: March 12, 2019
    Assignee: MEDSHINE DISCOVERY INC.
    Inventors: Wei Luo, Charles Z. Ding, Zhigang Huang, Shuhui Chen
  • FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR
    Publication number: 20180354953
    Abstract: Disclosed is a fused-ring or tricyclic aryl pyrimidine compound used as a mutation selectivity EGFR inhibitor. Specifically, disclosed is a compound represented by formula (I) and used as an EGFR inhibitor or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 20, 2016
    Publication date: December 13, 2018
    Inventors: Charles Z. DING, Shuhui CHEN, Baoping ZHAO, Xile LIU, Linxia XIAO, Chao DING, Fei WANG, Jian LI
  • Fused-ring or tricyclic aryl pyrimidine compound used as kinase inhibitor
    Patent number: 10093656
    Abstract: Disclosed is a fused-ring or tricyclic aryl pyrimidine compound used as a mutation selectivity EGFR inhibitor. Specifically, disclosed is a compound represented by formula (I) and used as an EGFR inhibitor or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: October 9, 2018
    Assignee: NANJING SANHOME PHARMACEUTICAL CO., LTD
    Inventors: Charles Z. Ding, Shuhui Chen, Baoping Zhao, Xile Liu, Linxia Xiao, Chao Ding, Fei Wang, Jian Li
  • SALT TYPE AND CRYSTAL TYPE OF 4H-PYRAZOLO [1, 5-ALPHA] BENZIMIDAZOLE COMPOUND AND PREPARATION METHOD AND INTERMEDIATE THEREOF
    Publication number: 20180258093
    Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1, 5-alpha]benzimidazole compound and the preparation method and intermediate thereof.
    Type: Application
    Filed: September 29, 2016
    Publication date: September 13, 2018
    Inventors: Xuehai WANG, Charles Z. DING, Jie SHEN, Shuhui CHEN, Lie LI, Gang LI, Yong XU, Cailin WANG, Ronghua TU, Jimeng WANG, Yang YUE, Biao DENG, Hailiang CHEN, Hui LIU, Wenjie SUN, Cong WANG, Lu HUANG, Zheng WANG, Weidong LI
  • Resorcinol derivative as HSP90 inhibitor
    Patent number: 10035792
    Abstract: The present invention relates to a compound represented by formula (I) of a resorcinol derivative as an HSP90 inhibitor or pharmaceutically accepted salts thereof. The compound in the present invention has the activity of inhibiting heat shock protein HSP90. Therefore, the compound in the present invention is used to treat proliferative diseases such as cancer and neurodegenerative diseases. The present invention further provides the compounds and preparation methods for pharmaceutical compositions comprising the compounds, a method for treating diseases, and pharmaceutical compositions comprising the compounds.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: July 31, 2018
    Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Shuhui Chen, Charles Z. Ding, Xiaobing Yan, Wei Huang, Guoping Hu, Jian Li, Xiquan Zhang, Ling Yang, Hongjiang Xu
  • ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE
    Publication number: 20180162878
    Abstract: Disclosed is a substituted nitroimidazole derivative, which is mainly used for treating related diseases caused by mycobacterial infections, such as Mycobacterium tuberculosis, especially being suitable for diseases caused by resistant Mycobacterium tuberculosis.
    Type: Application
    Filed: January 28, 2016
    Publication date: June 14, 2018
    Applicant: MEDSHINE DISCOVERY INC.
    Inventors: Wei LUO, Charles Z. DING, Zhigang HUANG, Shuhui CHEN
  • TOLL-LIKE RECEPTOR-7 AGONIST
    Publication number: 20180148452
    Abstract: Disclosed are a novel pyrrolopyrimidine ring compound as a TLR7 agonist or a pharmaceutically acceptable salt thereof, used for preventing or treating allergic rhinitis and asthma. In particular, disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 29, 2015
    Publication date: May 31, 2018
    Applicant: MEDSHINE DISCOVERY INC.
    Inventors: Charles Z. DING, Fei SUN, Lifang WU, Jinhua DU, Yasuhiro KATSU, Guoping HU, Jian LI
  • Substituted 2-hydrogen-pyrazole derivative serving as anticancer drug
    Patent number: 9969719
    Abstract: Disclosed is a substituted 2H-pyrazole derivative serving as a selective CDK4/6 inhibitor. Specifically, disclosed is a compound of formula (I) or a pharmaceutically acceptable salt thereof which serves as a selective CDK4/6 inhibitor.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: May 15, 2018
    Assignees: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., MEDSHINE DISCOVERY INC.
    Inventors: Charles Z. Ding, Shuhui Chen, Baoping Zhao, Zhaobing Xu, Yingchun Liu, Ruibin Lin, Fei Wang, Jian Li
  • Fused-Ring Or Tricyclic Aryl Pyrimidine Compound Used As Kinase Inhibitor
    Publication number: 20180072704
    Abstract: Disclosed is a fused-ring or tricyclic aryl pyrimidine compound used as a mutation selectivity EGFR inhibitor. Specifically, disclosed is a compound represented by formula (I) and used as an EGFR inhibitor or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 14, 2017
    Publication date: March 15, 2018
    Inventors: Charles Z. DING, Shuhui CHEN, Baoping ZHAO, Xile LIU, Linxia XIAO, Chao DING, Fei WANG, Jian LI
  • SUBSTITUTED 2-HYDROGEN-PYRAZOLE DERIVATIVE SERVING AS ANTICANCER DRUG
    Publication number: 20180072707
    Abstract: Disclosed is a substituted 2H-pyrazole derivative serving as a selective CDK4/6 inhibitor. Specifically, disclosed is a compound of formula (I) or a pharmaceutically acceptable salt thereof which serves as a selective CDK4/6 inhibitor.
    Type: Application
    Filed: March 10, 2016
    Publication date: March 15, 2018
    Inventors: Charles Z. Ding, Shuhui Chen, Baoping Zhao, Zhaobing Xu, Yingchun Liu, Ruibin Lin, Fei Wang, Jian Li
  • Resorcinol Derivative As HSP90 Inhibitor
    Publication number: 20180009794
    Abstract: The present invention relates to a compound represented by formula (I) of a resorcinol derivative as an HSP90 inhibitor or pharmaceutically accepted salts thereof. The compound in the present invention has the activity of inhibiting heat shock protein HSP90. Therefore, the compound in the present invention is used to treat proliferative diseases such as cancer and neurodegenerative diseases. The present invention further provides the compounds and preparation methods for pharmaceutical compositions comprising the compounds, a method for treating diseases, and pharmaceutical compositions comprising the compounds.
    Type: Application
    Filed: January 22, 2016
    Publication date: January 11, 2018
    Inventors: Shuhui CHEN, Charles Z. DING, Xiaobing YAN, Wei HUANG, Guoping HU, Jian LI, Xiquan ZHANG, Ling YANG, Hongjiang XU
  • JAK INHIBITOR
    Publication number: 20170360794
    Abstract: The present invention discloses a series of JAK inhibitors, and particularly discloses a compound of formula (I) or a pharmaceutically acceptable salt thereof and the use thereof in preparation of drugs for treating diseases related to JAK.
    Type: Application
    Filed: January 19, 2016
    Publication date: December 21, 2017
    Applicant: WUXI FORTUNE PHARMACEUTICAL CO., LTD
    Inventors: Hao WU, Weiwei MAO, Lili FAN, Charles Z. DING, Shuhui CHEN, Fei WANG, Guoping HU, Jian LI
  • PIPERIDINE-DIONE DERIVATIVES
    Publication number: 20170001990
    Abstract: The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 15, 2016
    Publication date: January 5, 2017
    Applicant: Genentech, Inc.
    Inventors: Jinhua CHEN, Charles Z. DING, Peter DRAGOVICH, Benjamin FAUBER, Zhenting GAO, Sharada S. LABADIE, Kwong Wah LAI, Hans Edward PURKEY, Kirk ROBARGE, Binqing WEI, Aihe ZHOU
  • BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20140011768
    Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
    Type: Application
    Filed: June 11, 2013
    Publication date: January 9, 2014
    Inventors: Tsutomu Akama, Yong-Kang Zhang, Charles Z. Ding, Jacob J. Plattner, Kirk R. Maples, Yvonne Freund, Virginia Sanders, Yi Xia, Stephen J. Baker, James A. Nieman, Xiaosong Lu, Marcelo Sales, Rashmi Sharma, Rajeshwar Singh, Robert Jacobs, Daitao Chen, Michael Richard Kevin Alley
  • Boron-containing small molecules as anti-inflammatory agents
    Patent number: 8461135
    Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: June 11, 2013
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Tsutomu Akama, Yong-Kang Zhang, Charles Z. Ding, Jacob J. Plattner, Kirk R. Maples, Yvonne Freund, Virginia Sanders, Yi Xia, Stephen J. Baker, James A. Nieman, Xiaosong Lu, Marcelo Sales, Rashmi Sharma, Rajeshwar Singh, Robert T. Jacobs, Daitao Chen, Michael Richard Kevin Alley
  • BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20120214765
    Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
    Type: Application
    Filed: September 19, 2011
    Publication date: August 23, 2012
    Applicant: Anacor Pharmaceuticals, Inc.
    Inventors: Tsutomu Akama, Yong-Kang Zhang, Charles Z. Ding, Jacob J. Plattner, Kirk R. Maples, Yvonne Freund, Virginia Sanders, Yi Xia, Stephen J. Baker, James A. Nieman, Xiaosong Lu, Marcelo Sales, Rashmi Sharma, Rajeshwar Singh, Robert T. Jacobs, Daitao Chen, Michael Richard Kevin Alley
  • Boron-containing small molecules as anti-inflammatory agents
    Patent number: 8039450
    Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: October 18, 2011
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Tsutomu Akama, Yong-Kang Zhang, Charles Z. Ding, Jacob J. Plattner, Kirk R. Maples, Yvonne Freund, Virginia Sanders, Yi Xia, Stephen J. Baker, James A. Nieman, Xiaosong Lu, Marcelo Sales, Rashmi Sharma, Rajeshwar Singh, Robert Jacobs, Daitao Chen, Michael Richard Kevin Alley